H2 receptori su pozitivno spregnut sa adenilat ciklazom preko Gs. H2 receptor je potentan stimulans cAMP produkcije. On povišava intraćelijske Ca2+ koncentracije i oslobađanje Ca2+ iz intraćelijskih zaliha. Lek betazol je primer agonistahistaminskog H2 receptora.
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„Histamine Receptors: H2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 25. 12. 2013. г.
H2+receptors на US National Library of Medicine Medical Subject Headings (MeSH)