GPR132

G protein-spregnuti receptor 132
G protein-spregnuti receptor 132
Identifikatori
Simboli	GPR132; G2A; MGC99642
Vanjski ID	OMIM: 606167 MGI: 1890220 HomoloGene: 8350 IUPHAR: GPR132 GeneCards: GPR132 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• G1/S prenos mitotičkog ćelijskog ciklusa; • prenos signal; • signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	29933
Ensembl	ENSG00000183484
UniProt	Q9UNW8
RefSeq (mRNA)	NM_013345
RefSeq (protein)	NP_037477
Lokacija (UCSC)	Chr 14:; 104.59 - 104.6 Mb
PubMed pretraga	[1]

GPR132, G protein-spregnuti receptor 132, je protein koji je kod čoveka kodiran GPR132 genom.^[1]^[2]

GPR132 je receptor visokog afiniteta za lizofosfatidilholin (LPC), jednu od fosfolipidnih komponenti oksidovanih lipoproteina niske gustine. Ovaj protein može da reaguje na promenu LPC nivoa na mestima zapaljenja i da ograniči ekspanziju ćelija ćelija koje infiltriraju tkivo. Sličan protein kod miša učestvuje u progresiji ćelijskog cilusa.^[2]

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Proton-indicirajući G protein-spregnuti receptori

Literatura

^ Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON (2002). „Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene”. Cancer Cell. 1 (4): 381—91. PMID 12086852. doi:10.1016/S1535-6108(02)00058-2.
^ ^а ^б „Entrez Gene: GPR132 G protein-coupled receptor 132”. PMID 29933. Недостаје или је празан параметар |url= (помоћ)

Dodatna literatura

Weng Z; Fluckiger AC; Nisitani S; et al. (1998). „A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.”. Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12334—9. PMC 22832 . PMID 9770487. doi:10.1073/pnas.95.21.12334.
Kabarowski JH; Zhu K; Le LQ; et al. (2001). „Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.”. Science. 293 (5530): 702—5. PMID 11474113. doi:10.1126/science.1061781.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Rikitake Y; Hirata K; Yamashita T; et al. (2002). „Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.”. Arterioscler. Thromb. Vasc. Biol. 22 (12): 2049—53. PMID 12482833. doi:10.1161/01.ATV.0000040598.18570.54.
Lin P, Ye RD (2003). „The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.”. J. Biol. Chem. 278 (16): 14379—86. PMID 12586833. doi:10.1074/jbc.M209101200.
Lum H; Qiao J; Walter RJ; et al. (2003). „Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.”. Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786—9. PMID 12805023. doi:10.1152/ajpheart.00359.2003.
Murakami N, Yokomizo T, Okuno T, Shimizu T (2004). „G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.”. J. Biol. Chem. 279 (41): 42484—91. PMID 15280385. doi:10.1074/jbc.M406561200.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Witte ON; Kabarowski JH; Xu Y; et al. (2005). „Retraction.”. Science. 307 (5707): 206. PMID 15653487. doi:10.1126/science.307.5707.206b.
Radu CG; Nijagal A; McLaughlin J; et al. (2005). „Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.”. Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632—7. PMC 545089 . PMID 15665078. doi:10.1073/pnas.0409415102.
Obinata H; Hattori T; Nakane S; et al. (2006). „Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.”. J. Biol. Chem. 280 (49): 40676—83. PMID 16236715. doi:10.1074/jbc.M507787200.
Frasch SC; Zemski-Berry K; Murphy RC; et al. (2007). „Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.”. J. Immunol. 178 (10): 6540—8. PMID 17475884.

[pmid12086852-1] Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON (2002). „Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene”. Cancer Cell. 1 (4): 381—91. PMID 12086852. doi:10.1016/S1535-6108(02)00058-2.

[entrez-2] а ^б „Entrez Gene: GPR132 G protein-coupled receptor 132”. PMID 29933. Недостаје или је празан параметар |url= (помоћ)

[1]

[2]

GPR132

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Literatura

Dodatna literatura

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