Perforin

Perforin
Pengidentifikasi
AliasPRF1, FLH2, HPLH2, P1, PFN1, PFP, perforin 1
ID EksternalOMIM: 170280; MGI: 97551; HomoloGene: 3698; GeneCards: PRF1; OMA:PRF1 - orthologs
Ortologi
SpesiesManusiaTikus
Entrez

5551

18646

Ensembl

ENSG00000180644

ENSMUSG00000037202

UniProt

P14222

P10820

RefSeq (mRNA)

NM_005041
NM_001083116

NM_011073

RefSeq (protein)

NP_001076585
NP_005032

NP_035203

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
Lihat/Sunting ManusiaLihat/Sunting Tikus

Perforin (bahasa Inggris: perforin, PRF) adalah sitokin berupa protein yang diekspresikan oleh gen PRF1.[3][4][5]

Perforin dapat ditemukan pada granul sel T CD8 dan sel NK. Setelah proses degranulasi, sekresi perforin akan tersisipkan pada membran sel dan membentuk sebuah lubang. Bagian perforin yang menancap pada membran tersebut adalah domain MACPF.[6]

Perforin bersinergi dengan membrane-attack complex (MAC) yang dilakukan protein komplemen seperti C5a dan C5b.[7]

Perforin juga berinteraksi dengan Kalretikulin.[8]

Rujukan

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Fink TM, Zimmer M, Weitz S, Tschopp J, Jenne DE, Lichter P (1992). "Human perforin (PRF1) maps to 10q22, a region that is syntenic with mouse chromosome 10". Genomics. 13 (4): 1300–2. PMID 1505959. Pemeliharaan CS1: Banyak nama: authors list (link)
  4. ^ Shinkai Y, Yoshida MC, Maeda K, Kobata T, Maruyama K, Yodoi J, Yagita H, Okumura K (1990). "Molecular cloning and chromosomal assignment of a human perforin (PFP) gene". Immunogenetics. 30 (6): 452–7. PMID 2592021. Pemeliharaan CS1: Banyak nama: authors list (link)
  5. ^ "Entrez Gene: PRF1 perforin 1 (pore forming protein)".
  6. ^ Tschopp J, Masson D, Stanley KK (1986). "Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis". Nature. 322 (6082): 831–4. doi:10.1038/322831a0. PMID 2427956. Pemeliharaan CS1: Banyak nama: authors list (link)
  7. ^ (Inggris) Janeway, Charles A.; Travers, Paul; Walport, Mark; Shlomchik, Mark (2001). Immunobiology. Garland Science. Diakses tanggal 2010-03-14. Pemeliharaan CS1: Banyak nama: authors list (link) Section 2-5
  8. ^ Andrin, C (1998). "Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules". Biochemistry. 37 (29). UNITED STATES: 10386–94. doi:10.1021/bi980595z. ISSN 0006-2960. PMID 9671507. ; ; ; ; Pemeliharaan CS1: Tahun (link)



Ikon rintisan

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.