CXCL10
CXCL10 (bahasa Inggris: interferon-gamma induced protein, γ-IP10, IP-10) adalah kemokina bermotif C-X-C dengan ligan 10, dan mempunyai massa 10 kDa.[4]
IP-10 disekresi oleh beberapa sel sebagai respon terhadap hormon IFN-γ, termasuk monosit, sel endotelial, dan fibroblas.[5]
IP-10 diketahui turut berperan sebagai:
- mediator kemotaksis bagi monosit, makrofaga, sel T, sel NK dan DC
- stimulan adhesi sel T ke sel endotelial
- aktivitas anti-tumor
- inhibitor pembentukan koloni pada sumsum tulang dan proses angiogenesis,[6][7] setelah mengikatkan dirinya pada permukaan sel pada pencerap kemokina CXCR3.[8]
Gen IP-10 terletak pada kromosom 4 pada kluster yang bersamaan dengan beberapa kemokina CXC lainnya.[9]
Rujukan
- ^ a b c GRCh38: Ensembl release 89: ENSG00000169245 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ (Inggris) CXCL10 - chemokine (C-X-C motif) ligand 10 Diarsipkan 2010-04-20 di Wayback Machine.
- ^ (Inggris)Luster et al. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315: 672-676, 1985. PMID 3925348
- ^ (Inggris)Dufour et al. IFN-gamma-inducible protein 10 (IP-10; CXCL10) -deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J. Immun. 168:, 2002. PMID 11907072
- ^ (Inggris)Angiolillo et al. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182: 155-162, 1995. PMID 7540647
- ^ (Inggris)Booth et al. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry 41:, 2002. PMID 12173928
- ^ (Inggris)O'Donovan et al. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84: 39-42, 1999. PMID 10343098
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