Protein-coding gene in the species Homo sapiens
Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene .[ 5] [ 6]
Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain . [ 7]
The MYO1E gene was included in several genetic signatures for cancer prognosis.[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000157483 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032220 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996). "Mapping of unconventional myosins in mouse and human" . Genomics . 36 (3): 431– 439. doi :10.1006/geno.1996.0488 PMID 8884266 . ^ "Entrez Gene: MYO1E myosin IE" .^ McConnell RE, Tyska MJ (July 2010). "Leveraging the membrane - cytoskeleton interface with myosin-1" . Trends in Cell Biology . 20 (7): 418– 426. doi :10.1016/j.tcb.2010.04.004 . PMC 2897960 PMID 20471271 . ^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning" . BioData Mining . 15 (1): 28. doi :10.1186/s13040-022-00312-y eISSN 1756-0381 . PMC 9632055 PMID 36329531 .
Further reading
Krendel M, Osterweil EK, Mooseker MS (February 2007). "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis" . FEBS Letters . 581 (4): 644– 650. doi :10.1016/j.febslet.2007.01.021 . PMC 1861834 PMID 17257598 . El Mezgueldi M, Tang N, Rosenfeld SS, Ostap EM (June 2002). "The kinetic mechanism of Myo1e (human myosin-IC)" . The Journal of Biological Chemistry . 277 (24): 21514– 21521. doi :10.1074/jbc.M200713200 PMID 11940582 . Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motility and the Cytoskeleton . 41 (4): 308– 324. doi :10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J . PMID 9858156 . Robertson H, Langdon WY, Thien CB, Bowtell DD (November 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochemical and Biophysical Research Communications . 240 (1): 46– 50. doi :10.1006/bbrc.1997.7608 . PMID 9367879 . Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (July 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types" . Proceedings of the National Academy of Sciences of the United States of America . 91 (14): 6549– 6553. Bibcode :1994PNAS...91.6549B . doi :10.1073/pnas.91.14.6549 PMC 44240 PMID 8022818 . Bement WM, Wirth JA, Mooseker MS (October 1994). "Cloning and mRNA expression of human unconventional myosin-IC. A homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain" . Journal of Molecular Biology . 243 (2): 356– 363. doi :10.1006/jmbi.1994.1662 PMID 7932763 .
External links
Overview of all the structural information available in the PDB for UniProt : E9Q634 PDBe-KB .
Information related to MYO1E
