As a true freshman at Alabama State in 2018, Isaac recorded 34 tackles, seven tackles-for-loss, seven pass breakups and an interception while being a starter due to injuries.[3] In 2019, he started all 11 games and posted 55 tackles, third-best on the team, as well as four tackles-for-loss and eight pass breakups.[5] In the COVID-19-impacted 2020–21 season, Isaac played only two games and had five tackles due to an injury that required surgery.[2][5] He appeared in 11 games in the fall 2021 season, totaling 33 tackles and seven pass breakups.[5] As a senior in 2022, he had 39 tackles, 10 pass breakups and two interceptions.[5] He was invited to the NFLPA Collegiate Bowl and to the HBCU Legacy Bowl.[6]
Isaac was selected in the sixth round (42nd overall) of the 2023 USFL draft by the Houston Gamblers.[8] After going unselected in the 2023 NFL draft, he signed with the Tampa Bay Buccaneers as an undrafted free agent.[6] He was released at the final roster cuts and subsequently re-signed to the practice squad.[9][10] He was elevated to the active roster for the team's Week 4 game against the New Orleans Saints, and made his NFL debut in the 26–9 win, appearing on 11 special teams snaps.[11][12] He was signed to the active roster on November 23.[13] Isaac was waived on December 11 and re-signed to the practice squad two days later.[14] He signed a reserve/future contract on January 23, 2024.[15] He was waived on August 27.[16]
Carolina Panthers
On August 28, 2024, Isaac was claimed off waivers by the Carolina Panthers.[17] He was waived on September 7.[18]
Tampa Bay Buccaneers (second stint)
On September 10, 2024, three days after being released by the Panthers, Isaac was re-signed by the Tampa Bay Buccaneers following a rash of injuries at the cornerback position during their season opener.[19] He was waived on September 20 and re-signed to the practice squad four days later.[20][21] Isaac was signed to the active roster on October 15.[22] He was waived again on November 12.
Las Vegas Raiders
On November 20, 2024, Isaac signed with the Las Vegas Raiders practice squad.[23] He signed a reserve/future contract on January 6, 2025.[24]
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