Interleukin-7 receptor-α

IL7R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DI2, 3DI3, 3UP1
Identifiers
Aliases	IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
External IDs	OMIM: 146661; MGI: 96562; HomoloGene: 1646; GeneCards: IL7R; OMA:IL7R - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	35,879,603 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	9,530,262 bp
RNA expression pattern
	Top expressed in
	right lung; ; granulocyte; ; lymph node; ; lower lobe of lung; ; epithelium of nasopharynx; ; appendix; ; blood; ; thymus; ; upper lobe of left lung; ; gallbladder;
	Top expressed in
	blood; ; mesenteric lymph nodes; ; spleen; ; thymus; ; tibiofemoral joint; ; subcutaneous adipose tissue; ; bone marrow; ; Paneth cell; ; pharynx; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antigen binding; interleukin-7 receptor activity; protein binding; cytokine receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; external side of plasma membrane; clathrin-coated vesicle membrane;
Biological process	regulation of cell size; regulation of DNA recombination; positive regulation of T cell differentiation in thymus; homeostasis of number of cells; negative regulation of T cell mediated cytotoxicity; cell surface receptor signaling pathway; B cell proliferation; T cell differentiation; positive regulation of gene expression; immune response; cell morphogenesis; lymph node development; immunoglobulin production; signal transduction; interleukin-7-mediated signaling pathway; positive regulation of cell population proliferation; positive regulation of receptor signaling pathway via STAT; membrane organization; negative regulation of T cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	3575
	16197
	ENSG00000168685
	ENSMUSG00000003882
	P16871
	P16872
	NM_002185
	NM_008372; NM_001355680
	NP_002176
	NP_032398; NP_001342609
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.^[5]^[6]

IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168685 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003882 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IL7R interleukin 7 receptor".
^ Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily". Cell. 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865. S2CID 45181020.

External links

IL7R+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P16871 (Human Interleukin-7 receptor subunit alpha) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: P16872 (Mouse Interleukin-7 receptor subunit alpha) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168685 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003882 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL7R interleukin 7 receptor".

[pmid2317865-6] Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily". Cell. 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865. S2CID 45181020.

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Interleukin-7 receptor-α

References

Further reading

External links

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