The Hounsfield unit (HU) scale is a linear transformation of the original linear attenuation coefficient measurement into one in which the radiodensity of distilled water at standard pressure and temperature (STP) is defined as 0 Hounsfield units (HU), while the radiodensity of air at STP is defined as −1000 HU. In a voxel with average linear attenuation coefficient , the corresponding HU value is therefore given by:[1][2]
where and are respectively the linear attenuation coefficients of water and air.
Thus, a change of one Hounsfield unit (HU) represents a change of 0.1% of the attenuation coefficient of water since the attenuation coefficient of air is nearly zero.[3]: 259
Calibration tests of HU with reference to water and other materials may be done to ensure standardised response. This is particularly important for CT scans used in radiotherapytreatment planning, where HU is converted to electron density.[4] Variation in the measured values of reference materials with known composition, and variation between and within slices may be used as part of test procedures.[3]: 283 [5]
Rationale
The above standards were chosen as they are universally available references and suited to the key application for which computed axial tomography was developed: imaging the internal anatomy of living creatures based on organized water structures and mostly living in air, e.g.humans.[citation needed]
Values for different body tissues and material
CT scan of the thorax with window level set to -700 HU (lung)CT scan of the thorax with window level set to -1,000 HU (air)CT scan of the thorax with window level set to 0 HU (water)CT scan of the thorax with window level set to 60 HU (liver)
Values reported here are approximations. Different dynamics are reported from one study to another.[citation needed]
Exact HU dynamics can vary from one CT acquisition to another due to CT acquisition and reconstruction parameters (kV, filters, reconstruction algorithms, etc.). The use of contrast agents modifies HU as well in some body parts (mainly blood).
A practical application of this is in evaluation of tumors, where, for example, an adrenal tumor with a radiodensity of less than 10 HU is rather fatty in composition and almost certainly a benign adrenal adenoma.[30]
^De Vos, W.; Casselman, J.; Swennen, G.R.J. (June 2009). "Cone-beam computerized tomography (CBCT) imaging of the oral and maxillofacial region: A systematic review of the literature". International Journal of Oral and Maxillofacial Surgery. 38 (6): 609–625. doi:10.1016/j.ijom.2009.02.028. PMID19464146.
^ abFosbinder, Robert; Orth, Denise (2011). Essentials of Radiologic Science. Lippincott Williams & Wilkins. p. 263. ISBN9780781775540.
^Wright, F. W. (2001). Radiology of the Chest and Related Conditions. CRC Press. p. 20.17. ISBN9780415281416.
^ abFast, Avital; Goldsher, Dorith (2006). Navigating the Adult Spine: Bridging Clinical Practice and Neuroradiology. Demos Medical Publishing. p. 17. ISBN9781934559741.
^Gaeta, Michele; Vinci, Sergio; Minutoli, Fabio; et al. (2001). "CT and MRI findings of mucin-containing tumors and pseudotumors of the thorax: pictorial review". European Radiology. 12 (1): 181–189. doi:10.1007/s003300100934. ISSN0938-7994. PMID11868096. S2CID28755973.
^Phuyal, Subash S.; Garg, Mandeep Kumar MK; Agarwal, Ritesh R; et al. (2015-09-02). "High-Attenuation Mucus Impaction in Patients With Allergic Bronchopulmonary Aspergillosis: Objective Criteria on High-Resolution Computed Tomography and Correlation With Serologic Parameters". Current Problems in Diagnostic Radiology.
^Kazerooni, Ella A.; Gross, Barry H. (2004). Cardiopulmonary Imaging. Vol. 4. Lippincott Williams & Wilkins. p. 379. ISBN9780781736558.
^Kuntz, Erwin; Kuntz, Hans-Dieter (2006). Hepatology, Principles and Practice: History, Morphology, Biochemistry, Diagnostics, Clinic, Therapy. Springer Science & Business Media. p. 210. ISBN9783540289777.
^Maatman, G. (2012). High-Resolution Computed Tomography of the Paranasal Sinuses and Pharynx and Related Regions: Impact of CT identification on diagnosis and patient management. Volume 12 of Series in Radiology. Springer Science & Business Media. p. 58. ISBN9789400942776.
^ abGivel, Jean-Claude; Merlini, Marco; Clarke, David B.; Dusmet, Michael (2012). Surgery of the Thymus: Pathology, Associated Disorders and Surgical Technique. Springer Science & Business Media. p. 488. ISBN9783642710766.
^ abRambow A, Staritz M, Wosiewitz U, Mildenburger P, Thelen M, Meyer zum Büschenfelde KH (1990). "Analysis of radiolucent gallstones by computed tomography for in vivo estimation of stone components". Eur J Clin Invest. 20 (4): 475–8. doi:10.1111/j.1365-2362.1990.tb01887.x. PMID2121509. S2CID39138974.
^Bolliger, Stephan A.; Oesterhelweg, Lars; Spendlove, Danny; et al. (2009). "Is Differentiation of Frequently Encountered Foreign Bodies in Corpses Possible by Hounsfield Density Measurement?". Journal of Forensic Sciences. 54 (5): 1119–1122. doi:10.1111/j.1556-4029.2009.01100.x. ISSN0022-1198. PMID19627414. S2CID40300162.
^Horwich, Perry J. (December 20, 2018). Eugene C Lin (ed.). "Adrenal Adenoma Imaging". Medscape. Retrieved July 28, 2023.