3-Chlorocathinone
3-Chlorocathinone (3-CC) is a psychostimulant drug of the cathinone family.[1][2][3][4] It is the analogue of the antidepressant and norepinephrine–dopamine reuptake inhibitor (NDRI) bupropion in which the N-tert-butyl group has been removed.[5][3][4] The drug is also the analogue of the stimulant 3-chloromethcathinone (3-CMC; clophedrone) in which the N-methyl group has been removed.[2][3][4] 3-CC is a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA).[3][4] Its EC50 values for induction of monoamine release are 64 nM for dopamine, 105 nM for norepinephrine, and 567 nM for serotonin in rat brain synaptosomes.[3][4] Hence, 3-CC shows almost 10-fold preference for induction of dopamine release over serotonin release and around 1.5-fold preference for induction of dopamine release over norepinephrine release.[3][4] The drug was encountered as a novel designer and recreational drug by 2020.[1] References
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