DOSEN PROFIL LENGKAP

Finally Oncovirinae, viruses that contain an oncogene, are categorized as oncogenic because they trigger the growth of tumorous tissues in the host. This...

Essentially a metabolic, phosphate-wasting disorder (not cancer), oncogenic osteomalacia, also known as tumor-induced osteomalacia/hypophosphatemic osteomalacia...

quickly cause tumors in animals and transform cells in culture into an oncogenic state. The polyproteins are cleaved into smaller proteins each with their...

An oncovirus or oncogenic virus is a virus that can cause cancer. This term originated from studies of acutely transforming retroviruses in the 1950–60s...

protein is a well-known example of an oncogenic fusion protein, and is considered to be the primary oncogenic driver of chronic myelogenous leukemia...

RAS. This interaction blocks downstream effector binding and inhibits oncogenic signaling. In 2026, daraxonrasib completed a phase 3 clinical trial (RASolute...

microRNAs (oncomirs) has been associated with specific cancer forming (oncogenic) events. Many different oncomirs have been identified in numerous types...

McBride AA (2017). "Perspective: The Promise of Proteomics in the Study of Oncogenic Viruses". Mol. Cell. Proteomics. 16 (4 suppl 1): S65–S74. doi:10.1074/mcp...

Sinkovics, Joseph (2011). "Molecular biology of oncogenic inflammatory processes. I. Non-oncogenic and oncogenic pathogens, intrinsic inflammatory reactions...

EWS/FLI1 is an oncogenic protein that is pathognomonic for Ewing sarcoma. It is found in approximately 90% of all Ewing sarcoma tumors with the remaining...

in pharmacology from Yale University, where she studied regulation of oncogenic mitogen-activated protein kinase signaling. Her Erdős-Bacon number is...

the viruses SV40, HHV-6, and cytomegalovirus (CMV). Infection with an oncogenic CMV may even be necessary for the development of glioblastoma. Research...

reflecting deaths from late-occurring metastatic disease. Activation of the oncogenic transcription factor gene MYB is the key genomic event of ACC and seen...

DNA damage or genomic instability, as discussed below for oncogenic viruses and an oncogenic bacterium.[citation needed] Viruses are one of the most important...

Oncogenic retroviridae proteins are retroviral proteins that have the ability to transform cells. They can induce sarcomas, leukaemias, lymphomas, and...

Memorial Sloan Kettering Cancer Center (MSKCC), which discovered its oncogenic function. It stands for "POK erythroid myeloid ontogenic [sic] factor"...

Exportin-5 (XPO5) is a protein that, in humans, is encoded by the XPO5 gene. In eukaryotic cells, the primary purpose of XPO5 is to export pre-microRNA...

multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity...

keratinocytes, abolishing the production of IL-8. However inhibition of TLR9 by oncogenic viruses is temporary, and patients with long-lasting HPV actually show...

chromosomes [t (9; 22) (q34; q11)] results in the fusion gene BCR::ABL1. The oncogenic protein with persistently enhanced tyrosine kinase (TK) activity transcribed...

invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome...

at the Dana–Farber/Harvard Cancer Center. He researches peptides and oncogenic pathways. In 2013, Walensky became director of the joint MD/PhD program...

is composed of at least 3 different sub-groups, each having distinct oncogenic mechanisms that respond to therapies in different ways. Germinal Center...

cells to make a hybrid line are via oncogenic viruses, polyethylene glycol, or electrofusion. Certain oncogenic viruses encode for fusogens, which are...

cells and the fact that the 4 transcriptional factors are shown to be oncogenic. In July 2014, during a scandal involving Japanese stem cell researcher...

humans. EBV is a double-stranded DNA virus. EBV is the first identified oncogenic virus, a virus that can cause cancer. EBV establishes a permanent infection...

have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of...

subjected to human papillomavirus infection. Indeed, DNA belonging to oncogenic HPV16 has been detected in cholesteatoma tissues, thereby underlining...

Novartis company, pelabresib targets epigenetic pathways to modulate oncogenic and inflammatory gene expression, offering a novel therapeutic approach...

proposed as possible treatment by down-regulating the expression of the oncogenic fusion protein associated with the development of Ewing sarcoma resulting...

conserved protein-protein interaction motif found in transcription factors, oncogenic proteins, ion channel proteins, and some actin-associated proteins. Oligodendrocyte...

clinical specimens across 15 cancer types. This study characterized the oncogenic properties of six RBPs—NSUN6, ZC3H13, BYSL, ELAC1, RBMS3, and ZGPAT—in...

diseases. Chronic diseases and cancers linked to infectious microbes List of oncogenic bacteria List of causes of death by rate − including specific infectious...

migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate MYC, FABP5, and cyclins A & E...

cells to modify the levels of existing translation factors. Several major oncogenic signaling pathways, including the RAS–MAPK, PI3K/AKT/mTOR, MYC, and WNT–β-catenin...

hamsters, SV40 causes a variety of tumors, generally sarcomas. In rats, the oncogenic SV40 large T antigen was used to establish a brain tumor model for primitive...

"Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation". Cancer and Metastasis Reviews...

diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a...

Choline kinase (also known as CK, ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine...

needed] In the United Kingdom, concern over the ptaquiloside-class of oncogenic natural products has led to application of special filters in processing...

implicating underlying tissue-specificity effects. Ependymomas arise from oncogenic events mutating normal ependymal cells into cancerous cells. Recent evidence...

been termed oncogene-induced senescence (OIS). Interestingly, even after oncogenic activation of a tissue, several researchers have identified a senescent...

hPG80 refers to the extracellular and oncogenic version of progastrin. This name first appeared in a scientific publication in January 2020. Until that...

microtubule polymerization. Nocodazole has been shown to decrease the oncogenic potential of cancer cells via another microtubules-independent mechanisms...

Dependence of tumor cells on a single oncogenic pathway or protein...

indicating the receptor is active. Analyzing NSCLC tissue samples identified oncogenic tyrosine kinases based on their phosphorylation profile and identified...

T lymphocytes (Effector tumor antigen-specific T cells) are cells of the immune system that attack and destroy virus-infected cells, tumor cells and cells...

but also involving many other tissues derived from the neural crest. Oncogenic factors, including mistranscription, are hypothesized to be related to...

interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling. Importantly, activity in the β-catenin destruction...

analyzes tumors based on biological system or histological subtype; (2) oncogenic processes, which considers the complex downstream impacts alterations...

when a key regulatory gene such as HRAS is incorporated, it may become oncogenic as the virus evolves for greater fitness. The benign version in the cellular...

models for viruses causing cancer in humans. His encyclopedic textbook Oncogenic Viruses is still considered a leading source book for early work in the...

inhibition of BRAF leads to an increase in its basal activity and hence is oncogenic. Vemurafenib, encorafenib, and dabrafenib are approved by the FDA for...

type II variant. The various lineages and sublineages have different oncogenic capacity, where overall, the non-European lineages are considered to increase...

leukemia and results in production of the BCR-abl fusion protein, an oncogenic tyrosine kinase. Small-scale mutations include point mutations, deletions...

oligodendroglioma, IDH1 and IDH2 mutations lead to overproduction of the oncogenic metabolite 2-hydroxyglutarate (2-HG), which results in impaired cellular...

(2012-08-14). "Autophagic activity dictates the cellular response to oncogenic RAS". Proceedings of the National Academy of Sciences. 109 (33): 13325–13330...

modulates a critical component in a growth-regulating pathway to bring about oncogenic effects. Agonists of the receptor include angiotensin (1-7). Antagonist...

cells by asbestos fibers remain unclear despite the demonstration of its oncogenic capabilities (see next-but-one paragraph). However, complete in vitro...

Miloslavskaya I, Demontis S, et al. (2005). "Regulation of cellular response to oncogenic and oxidative stress by Seladin-1". Nature. 432 (7017): 640–5. doi:10...

PMID 11615754. Frezza, Christian (March 2014). "The role of mitochondria in the oncogenic signal transduction". The International Journal of Biochemistry & Cell...

Levine has developed isolated polynucleotides and proteins related to oncogenic osteomalacia, along with methods to modulate bone mineralization and phosphate...

expression, may contribute to the progression of cellular transformation and oncogenic activity. Src family kinases contain six distinct domains including a...

tyrosine kinase that causes a type of cancer in chickens. The src gene is oncogenic as it triggers uncontrolled growth in abnormal host cells. It was the...

the YAP/TAZ-TEAD protein-protein interaction, a critical mediator of oncogenic signaling in the Hippo pathway. This drug has demonstrated potent and...

cancer. For example, individuals with cervical or anal infection with oncogenic, or cancer causing, strains of the human papilloma virus (HPV) are at...

E (Jun 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. ISSN 0950-9232...

overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated...

Croatia Alma mater University of Zagreb New York University Known for Oncogenic signaling, ubiquitin signaling Awards Gottfried Wilhelm Leibniz Prize...

syndrome Hypophosphatemia Chronic kidney failure Tumor-induced osteomalacia (Oncogenic osteomalacia) Long-term anticonvulsant therapy Celiac disease Cadmium...

promyelocytic leukemia protein (PML) nuclear bodies (also called PML oncogenic dots). Nuclear bodies also include ND10s. ND stands for nuclear domain...

later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor discovered. The proto-oncogene c-Jun is the cellular...

in cancer cells. Since the acetylation of STAT3 is important for its oncogenic activity and the fact that the level of acetylated STAT3 is high in cancer...

cell polyomavirus (Human polyomavirus 5, MCV, or MCPyV). The apparent oncogenicity of MCPyV similar to other cancer-causing viruses such as HPV, Epstein–Barr...

PMC 2180341. PMID 13130792. Dulbecco, R (1976). "From the molecular biology of oncogenic DNA viruses to cancer". Science. 192 (4238): 437–40. Bibcode:1976Sci....

gastrointestinal tract that were unrelated to poliovirus, and some of which were oncogenic (cancer-causing). The discovery of the coxsackieviruses yielded further...

factor at sites targeted by the disease. This increases the frequency of oncogenic mutation, leading to any dysfunction at checkpoints of autoimmune B-cell...

environment within states of chronic inflammation which gives rise to oncogenic potential. Viral agents are able to assist the formation of malignant...

which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved...

supervised by him) to isolate and characterize HPV16 and HPV18, the two most oncogenic HPV types causing the vast majority of HPV-induced anogenital and head-and-neck...

Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C (September 1999). "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which...

disrupting androgen receptor (AR) signaling and inhibiting AR expression by oncogenic ETS transcription factor, the fusion product regulates the prostate cancer...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein...

cervical disease: a review of the cost-effectiveness of vaccination against oncogenic HPV types". Journal of Managed Care Pharmacy. 16 (3): 217–230. doi:10...

polyomavirus, and human papillomavirus 31. Given the reactivation and/or oncogenic potential of these viruses, their repercussion on hematopoietic and malignant...

genome. Five pathways (RTK/RAS, p53, cell cycle, TGFB, and Hippo) are oncogenically deregulated or affected. The major mutational processes in LLC include...

complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/mcb.22...

expressing oncogenic β-catenin cells. IRS-1 dominant-negative mutant functions as tumor suppressor, whereas ectopic IRS-1 stimulates oncogenic transformation...

incidence of several cancers. This is primarily due to co-infection with an oncogenic DNA virus, especially Epstein-Barr virus (EBV), Kaposi's sarcoma-associated...

binding affinity for TrkC than TrkB. Although originally identified as an oncogenic fusion in 1982, only recently has there been a renewed interest in the...

Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C (Sep 1999). "Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in...

epigenetic mechanisms of chemotherapy resistance and therapies targeting oncogenic transcription factors. Since 2015, Kentsis' research in childhood cancer...

cannabinoid in the Cannabis sativa plant. It showed a great efficacy against oncogenic human cells. HU-331 does not cause arrest in cell cycle, cell apoptosis...

Samans B, Heukamp LC, Eilers UC, et al. (February 2008). "MYCN regulates oncogenic MicroRNAs in neuroblastoma". International Journal of Cancer. 122 (3):...

efficacy against solid tumors and hematological malignancies harboring oncogenic mutations that activate the RAS-RAF-MAPK signaling pathway. As of January...

observed in preneoplastic cells due to increased proliferation signals from oncogenic mutations. Replication stress is characterized by: increased replication...

hair follicles include epithelial cells that have been shown to have oncogenic potential, and have therefore been proposed as a possible site for a MCC...

Japan. In later studies, the virus has been found to be pathogenic and oncogenic to fish other than masu salmon, including coho salmon (O. kisutch), kokanee...

1). YAP1 is a transcriptional co-activator and its proliferative and oncogenic activity is driven by its association with the TEAD family of transcription...

HL (February 2004). "TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia". Science. 303 (5659): 848–51. Bibcode:2004Sci...

et al. (July 2007). "The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor...

and may play a role in prostate cancer progression. CARM1 exerts both oncogenic and tumor-suppressive functions. In breast cancer, CARM1 methylates chromatin...

search for promoters that respond to increased MYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma"...

types. the very strong proliferation capacity may be responsible for its oncogenic potential. Specifically, Trnp1 (together with other factors) serves as...

codons trigger oncogenic activity. Loss-of-function mutations often affect tumor suppressor genes such as NF1, TP53 and CDKN2A. Other oncogenic alterations...

cervical cancer and is similarly strongly associated with infection with oncogenic strains of human papillomavirus (HPV). Diagnosis of SCCV is done by pelvic...

cells show bystander responses when assayed for clonogenic survival and oncogenic transformation. This is also attributed to the bystander effect. The demonstration...

mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". The Journal of Experimental Medicine. 205 (1):...

by T-cell acute lymphoblastic leukemia (T-ALL) can be involved in the oncogenic development of T-ALL and offer novel insights into T-ALL spreading. The...

The results of several studies suggest that calcineurin inhibitors have oncogenic properties mainly linked to the production of cytokines that promote tumor...

eIF4E activities in cells including in its RNA export, translation and oncogenic activities lines. In AML patients treated with ribavirin, ribavirin blocked...

client proteins and is essential for conformational maturation of numerous oncogenic signaling proteins, including protein kinases and ligand-regulated transcription...

offers a modular framework for targeting specific DNA sequences, including oncogenic mutations. The biosensors hold potential for non-invasive diagnostics...

product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances...

et al. (November 1991). "A novel putative tyrosine kinase receptor with oncogenic potential". Oncogene. 6 (11): 2113–2120. PMID 1834974. Davidsen KT, Haaland...

show that the retinoblastoma gene could also be inactivated and made oncogenic through mutations of the promoter of the gene or by abnormal hypermethylation...

JR, Tuveson DA, Jaenisch, R, and Jacks, T. 2007. Sprouty-2 Regulates Oncogenic K-ras in Lung Development and Tumorigenesis. Genes & Development, 21(6):694-707...

X, See LH, Koch CM, Yen C, et al. (2003). "Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene". Cancer Cell. 3 (3): 297–302...

EG, Moses HL (2004). "TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia". Science. 303 (5659): 848–51. Bibcode:2004Sci...

therapies as their targets are these hallmarks. Telomeres were once thought oncogenic or cancer causing, but both María Blasco and BioViva added to evidence...

basic leucine zipper, and is known to be enhance HLTV-1 replication and oncogenicity. It is encoded in the opposite ("antisense") direction compared to all...

1172/JCI41959. PMC 2964969. PMID 20978349. Geisen C, Moroy T (October 2002). "The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies...

as well as more general signal transduction pathways. Pim-1's role in oncogenic signalling has led to it becoming a widely studied target in cancer research...

pathway is seen in all patients with LCH. In 50-60% of patients with LCH, oncogenic mutations of BRAFV600E are identified. 10-15% of patients have MAP2K1...

immature leukemic promyelocytes into mature granulocytes by targeting the oncogenic transcription factor and its aberrant action. Unlike other chemotherapies...

PIK3CA missense mutations in common human tumors. It has been found to be oncogenic and is implicated in cervical cancers. PIK3CA mutations are present in...

interfere with the TGF-β signaling pathway indirectly by inducing the oncogenic host mir17-92 cluster. These observations represents a novel mechanism...

translocations of MYC is seen in 90% of cases of Burkitt lymphoma, but these oncogenic translocations are not usually sufficient to cause lymphoma; other mutations...

M, von Kalle C, Verma IM (21 September 2006). "Gene therapy: Is IL2RG oncogenic in T-cell development?: X-SCID transgene leukaemogenicity (reply)". Nature...

by some infections such as Mycoplasma bacteria, raising the specter of oncogenic infection. Under normal, unstressed conditions, p53 is maintained at low...

residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important...

"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor." PLoS biology6.12 (2008): e301. Baar...

medications, such as tyrosine kinase inhibitors (TKIs), which target the oncogenic or signaling kinases linked to cellular proliferation. Preclinical models...

causes of aging in humans are cell loss (without replacement), DNA damage, oncogenic nuclear mutations and epimutations, cell senescence, mitochondrial mutations...

"Mycoplasma infection suppresses p53, activates NF-κB and cooperates with oncogenic Ras in rodent fibroblast transformation". Oncogene. 27 (33): 4521–4531...

Ullrich (1 September 1995). "Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3". The EMBO Journal. 14 (17):...

array of genes. Although the first ORF in these gammaherpesviruses have oncogenic potential, other viral genes may also play a role in viral transformation...

(June 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. PMID 10380882...

approximately 30–40% of BC cases. In triple-negative breast cancer (TNBC), oncogenic activation of the PI3K/AKT/mTOR pathway can happen as a function of overexpression...

activation, autoregulation, and repression via other transcription factors, oncogenic elements, or chemokines. C/EBPβ can interact with CREB, NF-κB, and other...

Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. (March 2007). "Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic...

targeted therapy, but such therapies historically focused on inhibition of oncogenic drivers (e.g. EGFR gain-of-function mutation and EGFR inhibitor treatment...

(March 2004). "Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF". Cell. 116 (6). Cancer Genome Project: 855–867. doi:10...

Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT (October 2011). "Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic...

Analysis of standard and defective viral genomes and viral sequences in oncogenically transformed cells". Proceedings of the National Academy of Sciences...

PMC 5528287. PMID 21376678. Gjerstorff MF, Andersen MH, Ditzel HJ (June 2015). "Oncogenic cancer/testis antigens: prime candidates for immunotherapy". Oncotarget...

S2CID 24567366. Cates CA, Michael RL, Stayrook KR, et al. (1997). "Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases". Cancer Lett. 110 (1–2):...

tumors, thyroid tumors, testicular seminomas and neuroblastomas. The oncogenic mechanism caused by mutated SHD is thought to relate to succinate's ability...

Marvaretta Stevenson take full responsibility for this error". "Upregulated Oncogenic Pathways in Patients Exposed to Tobacco Smoke May Provide a Novel Approach...

chemotherapy. HPV can induce tumors by several mechanisms: E6 and E7 oncogenic proteins. Disruption of tumor suppressor genes. High-level DNA amplifications...

First evidence of the importance of the ubiquitin/proteasome pathway in oncogenic processes was observed due to the high antitumor activity of proteasome...

Medveczky PG (January 1994). "Small RNA expression from the oncogenic region of a highly oncogenic strain of herpesvirus saimiri". Virus Genes. 8 (1): 25–34...

Diseases: HPV Status Identifies Distinct Mutational Profiles Including Oncogenic Fibroblast Growth Factor Receptor 3". Clinical Cancer Research. 23 (15):...

or DNA damage reagents. Furthermore, THOC5 is a substrate for several oncogenic tyrosine kinases, suggesting that THOC5 may be involved in cancer development...

contrast, tyrosine phosphorylation is induced by the presence of the KIT oncogenic mutation D816V. This KITD816V pathway is dependent on SRC protein family...

of integrating into a tumor suppressor gene or an oncogene, leading to oncogenic transformation of the cell. As a result, the most advanced therapies focus...

surrounding cancer, like the mechanisms and occurrences of genetic changes in oncogenic signaling pathways. The Pan-Cancer atlas shows the origins of more diverse...

JA; Thiagalingam S; Seymour A; Kinzler KW; Vogelstein B (May 1992). "Oncogenic forms of p53 inhibit p53-regulated gene expression". Science. 256 (5058):...

homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate GAL4–VP16-driven...

adhesion protein paxillin (human and chicken) and demonstrate its role in oncogenic transformation. As an independent clinician-scientist, Salgia's major...

Chemistry and in 1964 and 1966 an MSc in biology (Genetics) working on oncogenic viruses from Queen's University. She then pursued doctoral training at...

to Mdm2-mediated ubiquitylation and degradation of p53. In response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated...

Johnson V, Smyth J, Kortum R, Fawzi NL, Shewmaker F (September 2021). "The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase...

molecularly detect the presence of PML/RARA fusion protein, which is an oncogenic product of that translocation. The WHO classification of AML attempts...

carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship". Experimental...

Momeni-Boroujeni, Amir (December 2025). "FGFR1 Mutations Are Rare Alternate Oncogenic Drivers in FOXL2-Wildtype Adult Granulosa Cell Tumors of the Ovary". The...

cause multiple oncogenic events within a single cell cycle, providing a proliferative advantage to a (pre-)cancerous cell. Several oncogenic mutations in...

impact lymphoma-associated oncogenes like MYC, potentially leading to oncogenic rearrangements. The breakpoints in MYC rearrangements show considerable...

for anthropogenic risk factors strongly correlates with the number of oncogenic mutations in multiple cancer types, both sexes, and three countries –...

Symposium to Address Treatment and Prevention of Infectious Inflammatory and Oncogenic Disease. June 5, 2014. Miller School of Medicine at the University of...

"Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer". Cancer Research. 77 (13): 3502–3512. doi:10.1158/0008-5472...

Vessella RL, Atfi A, Dong JT (2007). "Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer". Oncogene. 26 (16): 2386–94. doi:10.1038/sj...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal...

the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined...

into hypermutated and non-hypermutated tumor types. In addition to the oncogenic and inactivating mutations described for the genes above, non-hypermutated...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog...

PMID 20129246. Raimondi V, Ciccarese F, Ciminale V (January 2020). "Oncogenic pathways and the electron transport chain: a dangeROS liaison". Br J Cancer...

Asadzadeh Aghdaei, H; Nazemalhosseini Mojarad, E; Ashrafian Bonab, M (2022). "Oncogenic Role of Connective Tissue Growth Factor Is Associated with Canonical TGF-β...

PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein...

Translocation creates the fusion protein KMT2A-AFF1 which is the primary oncogenic fusion that sets up the pre-leukemic conditions responsible for driving...

specific small-molecule inhibitors that specifically target the different oncogenic proteins and a comprehensive mechanistic analysis of the ways in which...

Melanie; Baker, Rohan T. (2004-10-18). "Nuclear-Cytoplasmic Shuttling of the Oncogenic Mouse UNP/USP4 Deubiquitylating Enzyme". Journal of Biological Chemistry...

5.2538. PMC 1569947. PMID 16552185. "Tumor Genetics; AKT Function and Oncogenic Activity" (PDF). Scientific Report. Fox Chase Cancer Center. 2005. Archived...

B, Hupp TR (2010). "A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin". J. Mol....

marker staining is performed for proliferation, lineage, prognostic and oncogenic targets. Pathologists used optical microscope for the evaluation through...

various cancers could indicate a role in cell growth regulation or a proto-oncogenic function. WDCP has known interactions with HCK, where a proline-rich region...

Somervaille TC (May 2014). "Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells". Leukemia. 28 (5): 1081–91. doi:10...

proliferation. Metabolic reprogramming in cancer is largely due to the oncogenic activation of signal transduction pathways and transcription factors....

miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities". Nat Med. 14 (11): 1271–7. doi:10.1038/nm.1880. PMID 18931683...

PMC 10291325. PMID 37378346. Aplan, Peter D. (January 2006). "Causes of oncogenic chromosomal translocation". Trends in Genetics. 22 (1): 46–55. doi:10...

phosphorylating histone H3. Furthermore, Aurora kinases are known to be oncogenic and overexpressed in various forms of cancerous growth, including leukemia...

morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse...

early-onset. Mak HH, Peschard P, Lin T, Naujokas MA, Zuo D, Park M (2007). "Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr-Met...

repression by a site-specific DNA-binding protein designed against an oncogenic sequence" (PDF). Nature. 372 (6507): 642–5. Bibcode:1994Natur.372..642C...

(1968). "Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses". Nature. 218 (5141): 582–3. Bibcode:1968Natur.218..582B. doi:10...

Higgs BW, Richman L, Jallal B, Ranade K, Yao Y (March 2012). "A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation...

antigenic variation can occur within subgroups, and all strains are oncogenic, but oncogenicity and the ability to replicate varies between subgroups. Groups...

oncogenic mammary epithelial cells required an autocrine PDGF/PDGFR signaling loop, and that cooperation of autocrine PDGFR signaling with oncogenic was...

In addition, "a long-term safety study in rats documented a lack of oncogenicity for wood creosote" The second supplement then defined the coal-derivative...

microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma". Cell. 147 (2): 370–81. doi:10.1016/j.cell.2011...

showing oncogenic traits in certain lymphomas and leukemias. FOXP3 which is crucial for regulatory T cell function has been shown to repress oncogenic pathways...

genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane...

that result in the loss of N-terminal regions produce MCF2 variants with oncogenic activity.[supplied by OMIM] GRCm38: Ensembl release 89: ENSMUSG00000031139...

gliomas and leukemias, are present in most cases and considered the main oncogenic driver. Tp53 are associated with more aggressive disease course. Imaging...

DNAJB1::PRKACA is continuing to drive FLC, but that the tumor has become oncogenically addicted. The histopathology of FLC is characterized by laminated fibrous...

least one piece of T-DNA, consisting of the opine synthesis genes, root oncogenic loci (rol) genes (rolA, rolB, rolC and rolD) and a number of other genes...

expression levels of other genes by several mechanisms. mir-221 is an oncogenic microRNA. It targets CD117, which then prevents cell migration and proliferation...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane...

explores their roles in human health and disease. The Rao Lab identified the oncogenic role of SPCA2 in breast cancer through an aberrant method of signalling...

Spliet WG, et al. (1 September 2014). "O9.06 * Prognostic Relevance and Oncogenic Correlates of Epilepsy in Glioblastoma Patients". Neuro-Oncology. 16 (suppl_2):...

MG (May 1996). "Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase"...

regulatory T cells and suppresses pro-inflammatory T helper 17 cells. List of oncogenic bacteria Infectious causes of cancer Pathogenic bacteria Kuwahara T, Yamashita...

apoptotic pathway related drug resistance include h-ras and bcl-2/bax. Oncogenic h-ras has been found to increase expression of ERCC1, resulting in enhanced...

"Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor". Science. 295 (5557): 1079–1082. Bibcode:2002Sci...

S2CID 2856065. Janssen JW, Schleithoff L, Bartram CR, Schulz AS (April 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and...

complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/mcb.22...

S2CID 25275795. Chu NJ, Armstrong TD, Jaffee EM (April 2015). "Nonviral oncogenic antigens and the inflammatory signals driving early cancer development...

statement requiring further data from non-clinical studies to assess oncogenic risk resulting from PEG-PAL treatments. Hyperphenylalanemia Lofenalac...

are currently in clinical trials to determine therapeutic applications. Oncogenic PKC-iota can promote melanoma cell invasion by activating Vimentin during...

stress. AMPK activation also reduces H3K27 methylation and limits the oncogenic properties of EZH2 by phosphorylating EZH2-T311. Experiments in mouse...

senescence. This generally prevents the onset of cancer from a single oncogenic mutation. In tumor cells, there is generally another mutation that inhibits...

sometimes integrated into the host genome, especially noticeable with oncogenic HPVs, but is not a normal part of the virus life cycle and a dead-end...

Abrams J, Ethier SP, Yang ZQ (Dec 2009). "Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer". Oncogene...

Bongarzone I, Rizzetti M, Pelicci PG, Pierotti MA (June 1994). "The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor...

Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants". Science. 277 (5324): 333–8. doi:10.1126/science.277.5324...

stroma of mammary tumors, which promote tumor growth through enhancing oncogenic IL-6 signaling. In addition, he highlighted how FABP4 also promotes cancer...

gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression. GRCh38: Ensembl release 89: ENSG00000100029...

Ma D, Tao Q, Han W (June 2014). "A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth". Oncogene. 33 (24): 3109–18...

other names, including nuclear domain 10 (ND10), Kremer bodies, and PML oncogenic domains. PML-nuclear bodies are named after one of their major components...

Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, et al. (August 2010). "Oncogenic role of the chromobox protein CBX7 in gastric cancer". Journal of Experimental...

(Apr 2001). "Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis". Cell Growth & Differentiation. 12 (4):...

February 2022. Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. Journal of Cell Science 112...

ebv-sisRNA-1 is the third most abundant EBV RNA generated during a highly oncogenic form of virus latency (latency III). Conservation of ebv-sisRNA sequence...

factor (GM-CSF). AU-rich elements also regulate the biosynthesis of proto-oncogenic transcription factors like c-Jun and c-Fos. Eukaryotic messages are subject...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane...

targeted therapy combinations for the treatment of cancers driven by oncogenic mutations in the RAS pathway". Cancer Research. 80 (16_Supplement): 1943...

PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein...

Fukushima T, et al. (2015-06-03). "Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation...

rapid inhibition of cell proliferation in response to cellular stress or oncogenic signals. miR-675 has been found to be upregulated in osteoarthritic cartilage...

and tumor aggressiveness. The mechanisms by which TBX3 contributes to oncogenic processes involve, in part, its ability to inhibit the tumor suppressor...

French-Israeli molecular biologist who has studied the structure and functions of oncogenic DNA viruses as well as the general mechanisms for regulating gene expression...

of RNAs simultaneously thereby reprogramming the cell to become more oncogenic. eIF4E impacts the extent of m7G RNA capping, splicing, export and/or...

this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed...

cofactor that facilitates KMT2A-mediated transcriptional activation of oncogenic programs. In normal physiology, menin acts as a tumor suppressor, but...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal...

Elad-Sfadia G, Ballan E, Kloog Y (November 2001). "Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation". Oncogene...

Gedatolisib binds to all PI3K catalytic subunit isoforms involved in oncogenic signaling approximately equally. A number of early phase clinical trials...

Transformation by Oncogenic Ras" 2007 http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/972-b "Pathways potentiated by oncogenic Ras to modulate...

PMID 1334406. Peles E, Levy RB, Or E, Ullrich A, Yarden Y (August 1991). "Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase...

sprifermin, have demonstrated an excellent safety profile with no reported oncogenic effects. GRCh38: Ensembl release 89: ENSG00000156427 – Ensembl, May 2017...

transcription factor. Gene fusions involving NTRK1 have been shown to be oncogenic, leading to the constitutive TrkA activation. In a research study by Vaishnavi...

Yoshida A, Hirata Y, Hashizume O, Yamazaki D, Miki H (November 2020). "The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis"...

nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity". Mol. Cell. Biol. 19 (1): 764–76. doi:10.1128/mcb.19.1.764. PMC 83933...

Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, et al. (July 2014). "Oncogenic transformation of diverse gastrointestinal tissues in primary organoid...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves...

which describes how cancer cells change their metabolism to become more oncogenic in order to proliferate and eventually invade other tissues in a process...

may set an inhibitory threshold in resting T cells. Cells containing oncogenic mutations in-vivo often responded by activating the INK4A/ARF/INK4B locus...

Short rotation coppice, an energy crop Src (gene), a family of proto-oncogenic tyrosine kinases SRC, the human orthologue of the Src gene SRC Computers...

complexes with the pocket proteins. pRb is one of the targets of the oncogenic human papilloma virus protein E7, and human adenovirus protein E1A. By...

analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters". Clinical Cancer Research. 18 (11): 3054–70. doi:10.1158/1078-0432...

carcinoma. Through the studies on many gastrointestinal cancers, the oncogenic roles of XB130 was shown. XB130 expression is significantly correlated...

Grayson, AR; Hsi, PT; Kharchenko, PV; Kuroda, MI; French, CA (2015). "The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large...

processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane...

experiment of v-Src, an oncogenic variant of Src, the importance of this phosphorylation site was confirmed. This oncogenic v-Src is a product of the...

[when?] it has been shown that trabectedin blocks DNA binding of the oncogenic transcription factor FUS-CHOP and reverses the transcriptional program...

A. (2022-05-02). "Precision Combination Therapies Based on Recurrent Oncogenic Coalterations". Cancer Discovery. 12 (6): OF1–OF18. doi:10.1158/2159-8290...

androgen-dependent adenocarcinomas through coactivation of mTORC1/2 and oncogenic AR signaling. FOXA1 in breast cancer is highly correlated with ERα+, GATA3+...

shared with Helicobacter species that infect carnivorous hosts. List of oncogenic bacteria Infectious causes of cancer CagZ Rust M, Schweinitzer T, Josenhans...

resulting from HPV. Circumcision is associated with a reduced prevalence of oncogenic types of HPV infection, meaning that a randomly selected circumcised man...

processors of commercial hexane to perform testing for subchronic toxicity, oncogenicity, reproductive toxicity, developmental toxicity, mutagencity, neurotoxicity...

Vemurafenib (Plexxikon's lead program) an oral, novel drug that targets the oncogenic BRAF mutation present in about half of melanoma cancers and about eight...

the 1970s and 1980s, Beug identified new pairs of oncogenes in avian oncogenic viruses. He was later among the first scientists to propose that the transformation...

functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression". Science Signaling. 4 (188): pt6. doi:10.1126/scisignal...

anticancer property of indole-3-carbinol is driven by specific targeting of oncogenic pathways. In two different studies using xenografted mouse model of melanoma...

safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition". Stem Cell Reports...

mechanism involves utilizing the drug's known antiparasitic action to disrupt oncogenic pathways and potentially trigger immunogenic responses in the host environment...

glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential". The Journal...

the acquisition by the rapidly proliferating megakaryoblast clones of oncogenic mutations in other genes. Chemotherapeutic regimens are used to treat...

genus of viruses is known for its propensity to target immune cells and oncogenicity, evident in the names of the four named species. Infection is usually...

to several polyomaviruses, including Merkel cell polyomavirus, present oncogenic potential. Several mechanisms have been described for regulating the transition...

Hernalsteens, JP (1975). "Acquisition of tumour-inducing ability by non-oncogenic agrobacteria as a result of plasmid transfer". Nature. 255 (5511): 742–3...

These proteins were originally characterized by their capacity to induce oncogenic transformation in a specific cell culture system, rat kidney fibroblasts...

Worley LA, Long MD, Duan S, Council ML, Bowcock AM, Harbour JW (2008). "Oncogenic mutations in GNAQ occur early in uveal melanoma". Invest Ophthalmol Vis...

(2017). "O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies". Leukemia. 31 (10): 2132–2142...

Gibbon-ape leukemia virus (GaLV) is an oncogenic, type C retrovirus that has been isolated from primate neoplasms, including the white-handed gibbon and...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal-...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar...

doi:10.1182/blood.V14.10.1151.1151. PMID 13813891. Corcos D (1990). "Oncogenic potential of the B cell antigen receptor and its relevance to heavy chain...

Johnson-Saliba M, Baker RT (2005). "Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme". J. Biol. Chem. 280 (1): 745–52...

researcher in tumor biology and translational oncology. His work focuses on oncogenic signaling and the molecular mechanisms of cell cycle control. From 1987...

C, Dockhorn-Dworniczak B, Mandahl N, Desmaze C, Peter M (Dec 1995). "Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation"...

human glioblastoma tumor, or brain cancer, STAT3 was shown to have an oncogenic or a tumor suppressor role depending upon the mutational background of...

in Bethesda, Maryland. He collaborated with Bob Gallo on studying how oncogenic viruses replicate, which included studies of reverse transcriptase. Wu...

subjected to human papillomavirus infection. Indeed, DNAs belonging to oncogenic HPVs, i.e., HPV16 and HPV18, have been detected in normal middle ear specimens...

Sather H, et al. (December 1999). "Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia". Journal of...

All those with pancreatic cancer require genetic testing as high risk oncogenic mutations may provide prognostic information and certain mutations with...

within the head and neck region or more distantly. This suggests that the oncogenic alterations produced by the virus are spatially limited rather than related...

understanding of how cellular signal transduction pathways are subverted in oncogenic transformation. His work provided the first demonstration that Guanosine...

factor 1". Resto VA, Caballero OL, Buta MR, et al. (2000). "A putative oncogenic role for MPP11 in head and neck squamous cell cancer". Cancer Res. 60...

resistance to diet- and leptin-mutation-induced obesity. The ALK gene can be oncogenic in three ways – by forming a fusion gene with any of several other genes...

protein belonging to the hyaluronidase family. Generally, oncogenic retroviruses cause transformation of host cells mostly by insertional...

(HPV16). 2020 – Published that strong vaccine responses against HPV16 oncogenic proteins in patients with late stage cervical cancer during chemotherapy...

especially its role as a signal attracting and transforming unique, oncogenic bacteria in genus Agrobacterium. The virA gene on the Ti plasmid of Agrobacterium...

Kepenekian, Vahan; Dupuy, Marie; Belouin, Fanny; Morency, Eric (2020). "The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers...

interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription...

meiosis. Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling...

and cellular oncoproteins manipulate cellular physiology to bring about oncogenic transformation. One of his most significant achievements was the biochemical...

E (July 2000). "Fos family members: regulation, structure and role in oncogenic transformation". Histol. Histopathol. 15 (3): 921–8. PMID 10963134. Fialka...

progression and metastasis, and evidence suggests that Skp2 plays a proto-oncogenic role both in vitro and in vivo. Skp2 overexpression has been seen in:...

cancer research as AXIN1 and AXIN2 work synergistically to control pro-oncogenic β-catenin signaling. Importantly, activity in the β-catenin destruction...

SOD2, and PRDX3 are decreased. SOD1, SOD2, and PRDX3 are known to be pro-oncogenic and be involved in chemotherapy resistance. Overall, altering NEK6 leads...

demonstrating the important role of protein subcellular localization in its oncogenic function and by establishing the function of ubiquitin ligases in key...

complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/MCB.22...

contribute to the regulation of gene expression, cellular differentiation and oncogenic transformation. This work has contributed to the resurgent interest in...

1038/nature02399. PMID 15057824. Okada K, Hirota E, Mizutani Y, et al. (2005). "Oncogenic role of NALP7 in testicular seminomas". Cancer Sci. 95 (12): 949–54. doi:10...

(2014-07-29). "HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties". Frontiers in Microbiology. 5: 398. doi:10.3389/fmicb.2014...

cancer; while this outcome has never been reported, some polyomaviruses are oncogenic. The natural history of untreated TS is not known and no long-term studies...

fusion genes can, in most cases, be shown to function independently as oncogenic drivers, capable of activating critical downstream pathways involved in...

imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation". Mol. Cell. Biol. 28 (1): 422–34. doi:10.1128/MCB.02335-06...

first-in-class medication. Midostaurin was found to be active against oncogenic CD135 (FMS-like tyrosine kinase 3 receptor, FLT3), in preclinical studies...

Johnson V, Smyth J, Kortum R, Fawzi NL, Shewmaker F (September 2021). "The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase...

degradation through recruitment of the β-TrCP E3 ligase. He further showed that oncogenic K-Ras can be stabilized by the loss of APC, leading to reactivation of...

Santoro, M (2003). "Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo3,4-dpyrimidine...

Bakleh A, Krasnitz A, Nguyen KC, Lakshmi B, et al. (October 2007). "Oncogenic cooperation and coamplification of developmental transcription factor...

infecting the skin and mucous membranes, their biology, pathogenicity or oncogenic potential, to understanding the mechanisms and factors involved in the...

Sauvage FJ, Sasaki H, Hui CC, Dlugosz AA (September 2002). "Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin...

may be prescribed for the treatment of HPV infections both benign and oncogenic, as a very safe and effective alternative therapy. Usually it is administered...

fusion protein has constitutively active kinase activity that causes oncogenic transformation (a transformation from normal cells to cancer cells). Loss...

that grow uncontrollably, usually as a result of an internal change or oncogenic mutations within the cell. Cancer develops and progresses as the microenvironment...

2013). "Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma". Cell. 153 (1): 71–85. doi:10.1016/J.CELL...

10.2). The first non-receptor tyrosine kinase identified was the v-src oncogenic protein. Most animal cells contain one or more members of the Src family...

between archaic and modern human ancestors during the evolution of the oncogenic human papillomavirus 16". Molecular Biology and Evolution. 34 (1): 4–19...

RE (November 2014). "CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer". Cell. 159 (5): 1126–39. doi:10.1016/j...

antigens expressed by tumors have several sources; some are derived from oncogenic viruses like human papillomavirus, which causes cancer of the cervix,...

level." An alternative vaccine known as Cervarix protects against two oncogenic strains of HPV, 16 and 18. The National Cancer Institute says, "To date...

mutants isolated from different tumor entities often exhibit a higher oncogenic potential than wild type CK1δ there are also great efforts to generate...

receptors to contribute to the growth and spread of cancers initiated and/or oncogenic Ras and possibly other oncogenes. This is supported by findings that BLT2...

AKT8. The gene codes for a protein kinase. Human homologs of the AKT8 oncogenic protein were identified in 1987.By 1995 it had been found that Akt kinases...

junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. When MUC4 and ErbB2 are able to interact, they trigger an activation...

complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Molecular and Cellular Biology. 22 (5): 1307–16. doi:10...

Liu F, Cheng Z, Wang D, Wang G, Xu H, Zhao Y, Cao L, Li F (June 2014). "Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis". Oncogene...

how much of the gene control program in cancer cells is amplified by oncogenic transcription factors such as c-MYC. According to Young, most genes experience...

1qym: X-ray structure of human gankyrin 1tr4: Solution structure of human oncogenic protein gankyrin 1uoh: HUMAN GANKYRIN 2dvw: Structure of the Oncoprotein...

analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1". Proc. Natl...

highly potent RasCAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. This compound inhibits farnesyltransferase (Ftase) in vitro...

PMID 34649219. S2CID 238990829. Karmokar PF, Moniri NH (December 2022). "Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast...

"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor". PLOS Biology. 6 (12): 2853–68. doi:10...

damages, when present in replicating cells, can cause an increase in oncogenic mutations through error-prone translesion synthesis during replication...

Immunodeficiency Virus (HIV) Status Drives Diffuse Large B Cell Lymphoma through Oncogenic Signaling Pathways". Blood. 130 (Supplement 1): 5128. doi:10.1182/blood...

factors bind to promoter regions of DNA and regulate the transcription of oncogenic genes: MYC The MYC family of transcription factors is one of the most...

epithelium and that is prone to both intestinal differentiation as well as oncogenic transformation. Following GERD this HOXA13-expressing compartment outcompetes...

epithelial cells. Oncogenesis occurs in the nasal turbinate cells A typical oncogenic virus will cause a mutation in a host cell, causing the transformation...

expression of and/or mutate the three oncogenes (i.e. MDM2, MDMX, and oncogenic mutant p53) because these biomarkers are involved in the formation of...

factors associated with various cancer types through observation of the oncogenic mechanism on a molecular scale. The luminal B cancer pathway exhibited...

early stages of cancer, can affect tumor development via interaction with oncogenic cytokines. Increased expression of TGF-β has been associated with the...

isoform accompanies its activation on cell membranes, and established that oncogenic mutations activate PI3Ks by mimicking or enhancing these conformational...

chromosome 7 where the MET gene is positioned, resulting in the promotion of oncogenic pathways in renal epithelial cells. Typically, the MET gene is upregulated...

signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14329–14333. Bibcode:2000PNAS...

Tembo KM, Deng X, Xiong M, et al. (February 2016). "CCR9 in cancer: oncogenic role and therapeutic targeting". Journal of Hematology & Oncology. 9 (1)...

2HS0, 2HS3, and 2HS4. This enzyme participates in purine metabolism. Oncogenic and physiological signals lead to the ERK-dependent PFAS phosphorylation...

invasive growth, chromosomal abnormalities, and mutations in crucial oncogenic pathways. In 2006, a study done by Szatmári et al. provided one of the...

by transforming mutants of Cbl: implications for Cbl's function and oncogenicity". Molecular and Cellular Biology. 17 (8): 4597–4610. doi:10.1128/mcb...

Ecarot B (2001). "Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone". Genomics. 74 (3):...

a desirable class of antineoplastic agents. Indeed, many of the proto-oncogenic "driver" mutations are tied to ERK1/2 signaling, such as constitutively...

1038/201423a0. PMID 14110027. S2CID 4276918. Robl MG, Olson C (1968). "Oncogenic action of bovine papilloma virus in hamsters". Cancer Res. 28 (8): 1596–604...

Verhaar AP, Yu B, Silva RA, et al. (June 2021). "HOXA13 in etiology and oncogenic potential of Barrett's esophagus". Nature Communications. 12 (1) 3354...

investigating the MDM2 inhibitor milademetan versus trabectedin, a blocker of the oncogenic transcription factor FUS-CHOP, in MDM2-overexpressing ALT/WDL and DDL...

not display hyaluronidase activity but does serve as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related...

Kociba; et al. (1978). "Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8- tetrachlorodibenzo-p-dioxin in rats". Toxicol. Appl...

Neoantigens are often associated with tumor antigens and are found in oncogenic cells. Neoantigens and, by extension, neoantigenic determinants can be...

PMID 12072198. Kitamura Y, Hirotab S (December 2004). "Kit as a human oncogenic tyrosine kinase". Cellular and Molecular Life Sciences. 61 (23): 2924–2931...

Project at the Institute of Medical Biology aimed at identifying all oncogenic alterations in all protein tyrosine kinase (PTK) gene transcripts of a...

Cervarix is indicated for the prevention of the following diseases caused by oncogenic HPV types 16 and 18: cervical cancer, cervical intraepithelial neoplasia...

genes and on the role played by steroid hormone receptors as well as oncogenic viruses in producing cancer cells. He has done pioneering research on...

non-responsive cancer cells, a quality which allows VSIV to grow and lyse oncogenic cells preferentially. Recently, attenuated VSIV with a mutation in its...

papillomaviruses. These differences in the E2 proteins likely determine how oncogenic a virus is. The noncoding region has a homologies with BPV1. Other homologies...

Alimonti A, Chen Z, Gao Z, et al. (January 2007). "NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN". Cell. 128 (1): 129–39. doi:10.1016/j.cell...

mutations affect alternative splicing of several transcripts, including oncogenic ROS1 fusions. U2af1 conditional deletion in mouse hematopoietic system...

Mark; Han, Sumin; Jernigan, Danielle L. (2013-01-02). "Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes". The Journal...

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as...

Unlike animals that contain few ILK genes ILKs have been found to possess oncogenic properties. ILKs control the activity of serine/threonine phosphatases...

human cells, trans-splicing can also be the mechanism behind certain oncogenic fusion transcripts. Spliced leader (SL) trans-splicing is used by certain...

Chinnaiyan, AM (2007). "Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer". Nature. 448 (7153): 595–9. Bibcode:2007Natur...

infection among mice varies significantly, and not all MPyV strains are oncogenic. In general, only newborns and immunosuppressed mice (usually transgenic)...

1989" (PDF). Vogt, Peter K. (1992). "A transcription factor becomes oncogenic". Cancer. 69 (10): 2610–2614. doi:10.1002/1097-0142(19920515)69:10<26...

inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Chimeric antigen receptor (CAR)...

suggest it may have a role in tumor development, though whether it is oncogenic or tumor suppressive is unclear, as there is data in support of both arguments...

in its inactive GDP-bound state and thereby preventing the downstream oncogenic signaling that drives tumor growth. The compound demonstrates significantly...

adult T cell leukaemia (ATL), and Tax has largely been implicated in the oncogenic potential of this virus. In addition to Tax's ability to promote the transcription...

Shen L, Shi Q, Wang W (March 2018). "Double agents: genes with both oncogenic and tumor-suppressor functions". Oncogenesis. 7 (3) 25. doi:10.1038/s41389-018-0034-x...

forms complexes with Frizzled receptors, initiating developmental and oncogenic signaling cascades. WNT1 is a secreted glycoprotein that plays an important...

identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells". Chemistry & Biology. 15 (3): 234–245. doi:10...

ER alpha-positive breast cancer. Smurf1 may the potential to act as an oncogenic factor in other essential organs of the body. For instance, high levels...

that this protein alternation could be the critical contributor to AG oncogenicity since mice showed an enhanced cell proliferation rate after intracranial...

the SV40 DNA tumour virus as a model for eukaryotic gene expression and oncogenic transformation led her to the study of p53. Since the late 1980s, her...

Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa...

product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances...

"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor". PLOS Biology. 6 (12): 2853–2868. doi:10...

carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol...

that are normally silenced, over-expressed gene products, products of oncogenic viruses, oncofetal antigens (proteins normally expressed only during development...

thus repressing gene expression. BASP1 binds to and/or regulates several oncogenic proteins, including WT1. It is believed to play a key role in keeping...

Cimadom L, Zadran SK, Perini G, Milazzo G (November 2021). "Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs"...

indicates unknown function. Missense mutations commonly resulting in oncogenic growths were identified at various sites within the coding region. Via...

2018-06-18 Hlavatá, L; Aguilaniu, H; Pichová, A; Nyström, T (2003). "The oncogenic RAS2val19 mutation locks respiration, independently of PKA, in a mode...

Wong V, Stagljar I (June 2021). "Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches". Oncogene. 40 (24): 4079–4093....

caused by oncogenic human papillomavirus 16 (HPV16). Furthermore, cervix intraepithelial neoplasia (CIN) is primarily caused by oncogenic HPV16. As in...

Mann RK, Milenkovic L, Scott MP, Beachy PA (August 2000). "Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine". Nature...

carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship". Experimental...

TAg, other polyomavirus large T antigens, adenovirus E1a proteins, and oncogenic human papillomavirus E7 proteins share a structural motif that encodes...

"Symposium to Address Treatment and Prevention of Infectious Inflammatory and Oncogenic Disease". College of Medicine. 2014-06-05. Retrieved 2025-06-17. Worobey...

altered in multiple human cancers and is a negative regulator of the oncogenic Phosphoinositide 3-kinase/Akt signaling pathway. Three studies have identified...

Jeffrey R; Dressman, Holly K; West, Mike; Nevins, Joseph R (2006). "Oncogenic pathway signatures in human cancers as a guide to targeted therapies"...

Gerardo Hospital, Monza, Italy. He was Senior Investigator and Head of the Oncogenic Fusion Proteins Unit at the National Cancer Institute, Milan Italy from...

the University Children's Hospital Zurich. His research focuses on the oncogenic transcriptional, epigenetic and posttranscriptional mechanisms in childhood...

Adnan M; et al. (2011). "Prognostic and Clinicopathologic Associations of Oncogenic BRAF in Metastatic Melanoma". Journal of Clinical Oncology. 29 (10): 1239–1246...

tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma". Blood...

(October 2024). "Bioinformatic analysis of molecular characteristics and oncogenic features of CARD14 in human cancer". Scientific Reports. 14 (1): 22972...

other cancers, and therefore promotes lethal metastasis. Many of these oncogenic effects of SOX9 appear dose-dependent. SOX9 is mostly localized in the...

activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP". Oncogene. 31 (2): 238–50. doi:10.1038/onc.2011.224. hdl:10023/2489...

(May 2023). "The Role of PARP-1 and NF-κB in Bile-Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells". Laryngoscope. 133 (5): 1146–1155. doi:10...

of the three known oncogenic HPV proteins, was reported in 2012 to be a viroporin. This was the first known example of an oncogenic viroporin. Because...

soft part sarcoma (ASPS). It has been found that ASPSCR1 can undergo oncogenic rearrangement with transcription factor TFE3 gene, creating an aberrant...

that blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and phosphatidylinositol-3-OH kinases and termed it 'multitargeted...

through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2". Cell Death and Differentiation. 27 (3): 1105–1118...

retrovirus encoded a tyrosine kinase binding domain, and that this was the oncogenic form as retroviruses carrying full-length c-Cbl did not induce tumor formation...

30;497(7451):633-7. 2012 Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic...

PMC 3528789. PMID 18394936. Raulet, David H.; Guerra, Nadia (2009). "Oncogenic stress sensed by the immune system: role of natural killer cell receptors"...

Transferase Regulates Breast Cancer Tumorigenesis Through Targeting of the Oncogenic Transcription Factor FoxM1". Oncogene. 29 (19): 2831–42. doi:10.1038/onc...

Upson JJ, Smith CD (Dec 2004). "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase". Oncogene. 23 (57): 9230–7....

processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant...

biopsies. The tissue samples were used to characterize brain tumors by oncogenic mapping. His work on genomics and proteomics helped led to advances in...

done with Drosophila Notch and C. elegans lin-12, informed by the first oncogenic mutation affecting a human Notch gene. Compelling evidence for this model...

diverse processes, including cell proliferation control, activity of proto-oncogenic proteins, apoptosis, centrosome duplication, and organization of neuronal...

prostate, pancreatic, breast, and colon cancers. NDRG1 has marked anti-oncogenic activity, being associated with decreased cell proliferation, migration...

Z, Armstrong SA, Kentsis A (July 2017). "PGBD5 promotes site-specific oncogenic mutations in human tumors". Nature Genetics. 49 (7): 1005–1014. doi:10...

growing body of evidence that the monkey, like the mouse, could harbor oncogenic (cancer-causing) viruses that could affect other animal species. In 1998...

Hong C, et al. (2004). "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf". J. Clin. Invest. 113 (4): 539–50. doi:10.1172/JCI18829...

USA, Washington, D.C., 1961. Kenemans P, Verstraeten RA, Verheijen RH. Oncogenic pathways in hereditary and sporadic breast cancer. Maturitas 2008; 61:...

hindbrain. Recently, Brpf1 was reported to play the tumor suppressor or oncogenic role in several malignant tumors, including leukemia, medulloblastoma...

cells are positive for the Philadelphia chromosome harboring the BCR-ABL oncogenic fusion. KBM-7 cells have been reprogrammed to yield the HAP1 cell line...

"Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML". Blood. 104 (8): 2532–2539...

oncoviruses capable of inducing neoplastic transformation in some cells. In oncogenic polyomaviruses, the tumor antigens are responsible for the transformation...

Kornblum, HI; Cloughesy, TF; Nelson, SF; Mischel, PS (2006). "Analysis of Oncogenic Signaling Networks in Glioblastoma Identifies ASPM as a Novel Molecular...

"Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis". Cancer Cell. 20 (5):...

inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during...

regulate entry into mitosis, and showed that mutations in these genes can be oncogenic because they cause chromosome instability. This work contributed to the...

Ohmura S, Orth MF, Knott MM, Colombo MV, Arrigoni C, et al. (May 2020). "Oncogenic hijacking of a developmental transcription factor evokes vulnerability...

through mutations in the ATP binding pocket or activation of alternative oncogenic pathways. Much research is being carried out on understanding the ways...

have found bacteria associated with different types of cancers. List of oncogenic bacteria Infectious causes of cancer Chronic diseases and cancers linked...

adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation". Nature. 358 (6388): 690–692. Bibcode:1992Natur.358..690G...

tissue. However, chromosomal translocation and fusion give rise to an oncogenic form of ALK that has been implicated in progression of NSCLC. Ceritinib...

(2008-11-01). "Capns1, a new binding partner of RasGAP-SH3 domain in K-RasV12 oncogenic cells: Modulation of cell survival and migration". Cellular Signalling...

to genotoxic therapies. Alternatively, 1p/19q loss might be an early oncogenic lesion promoting the formation of glial neoplasms, which retain high sensitivity...

premature aging. This gene has been found to be involved in maintenance of oncogenic transformation. GRCh38: Ensembl release 89: ENSG00000187531 – Ensembl...

PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein...

L2 by linking together short amino acid sequences of L2 from different oncogenic HPV types or by displaying L2 peptides on a more immunogenic carrier....

Information, U.S. National Library of Medicine. Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes"....

not be transformed by oncogenic forms of H-Ras without simultaneous inhibition of PP2A activity. Increased activity of oncogenic kinases is not sufficient...

in bladder cancer. Lastly, tumors can have dysregulation in upstream oncogenic signaling pathways like the phosphatidylinositol 3-kinase (P13K) pathway...

2013). "HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations". The Journal of Clinical Investigation. 123 (9): 3664–3671...

lead to cervical cancer over time. Campo's research group viewed the oncogenic effects of HPV can linger in females for a prolonged period of time, leading...

(BANCR), a 693-bp four-exon transcript, was first identified in 2012 as an oncogenic long non-coding RNA in BRAFV600E melanomas cells and was found to be associated...

screening should not begin under 30 years of age. Primary testing for oncogenic HPV can be used in a population-based program for cervical cancer screening...

family are found to be acting as a tumor suppressor or a factor driving oncogenic processes in human diseases, specifically and most notably in solid cancers...

morphology, gene transcription, proliferation, differentiation, apoptosis and oncogenic transformation. Other functions involve smooth muscle contraction, actin...

cancers that underexpress let-7. Lung cancer, for instance, has several key oncogenic mutations including p53, RAS and MYC, some of which may directly correlate...

PMID 26855137. Valton AL; Dekker J (February 2016). "TAD disruption as oncogenic driver". Current Opinion in Genetics & Development. 36: 34–40. doi:10...

Zhang W, Dong Y, et al. (May 2019). "Membrane-tethered Notch1 exhibits oncogenic property via activation of EGFR-PI3K-AKT pathway in oral squamous cell...

differentiation-active genus of Gram-negative bacteria Agrobacterium, a plant pathogen (oncogenic) genus of Gram-negative bacteria, also of biotechnologic use Escherichia...

of connective tissue (a sarcoma). Thus, RSV became known as the first oncogenic retrovirus that could be used to study the development of cancer molecularly...

C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation". Proc. Natl. Acad. Sci. U.S.A. 92 (23): 10467–71. Bibcode:1995PNAS...

susceptible hosts. Infection by A. tumefaciens involves the transfer of an oncogenic plasmid from the bacterium to the host cell nucleus, while quorum sensing...

oxidative burst for mitogenic pathway stimulation in oncogenic KRAS cells. However, in oncogenic Kras mice fibroblasts, NADPH oxidase inhibitors have...

Ferreira, R. C.; Maricato, J. T.; Janini, L. M.; Briones, M. R. S. (2026). "Oncogenic HPV types identified in Paleolithic and Chalcolithic human genome sequencing...

phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent...

Cheng YW, Tang FM, Lin YS (September 2002). "Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function". EMBO J...

roles of these domains remain unclear. It has been shown CDC6 shows proto-oncogenic activity. Cdc6 overexpression interferes with the expression of INK4/ARF...

cell death through an association with Myc. In human cells expressing oncogenic Ras or Raf, it was found the loss of SCRIB resulted in the invasion of...

signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14329–33. Bibcode:2000PNAS...

metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. Gut, 65(4), 647–657...

identified and paved the way to subsequent studies on the mechanism of oncogenic transformation. In 1979, Brugge took an assistant professor position at...

the first genetic corrections of human skin tissue, defined the minimal oncogenic gene set needed to transform normal human tissues into cancer, and identified...

microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma". Cell. 147 (2): 370–81. doi:10.1016/j.cell.2011...

undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases. Drug Resist Updat 76: 101118. Kang, MR; Yang, G; Place, RF; Charisse...

apoptosis, and cellular transformation for further differentiation. Due to oncogenic properties of c-Myc, evidence indicates that expressing only Oct4, Sox2...

relationship of RASSF1A and HPV. RASSF1A promoter hypermethylation and oncogenic HPV were detected in ACs, but SCCs displayed a high level of HPV DNA and...

transcription(RT)-PCR to evaluate for presence of BCR-ABL1, JAK2 & other oncogenic mutations, and CT scan to evaluate for organomegaly/LN involvement. Consensus...

Sun T, Liu J, Arlinghaus RB (January 2003). "Bcr and Abl interaction: oncogenic activation of c-Abl by sequestering Bcr". Cancer Research. 63 (2): 298–303...

derived from NIH-3T3 fibroblasts exhibited early transformation markers, oncogenic mutations, and autophagy pathway dependency for survival (Zhang et al...

PMID 10749966. Chang, Y; Moore, PS; Weiss, RA (October 2017). "Human Oncogenic Viruses: Nature and Discovery". Philosophical Transactions of the Royal...

Agarwalla, Pankaj K.; Listewnik, Marc L.; Dias-Santagata, Dora (2016-05-01). "Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma"...

Kuehl WM, Staudt LM (Feb 2004). "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological...

RNAP II recruitment and the associated transcription factors from proto-oncogenic regions. GRCh38: Ensembl release 89: ENSG00000185420 – Ensembl, May 2017...

A; Harel-Bellan, A; Negrutskii, B; Groisman, I (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target...

Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, et al. (February 2011). "Oncogenically active MYD88 mutations in human lymphoma". Nature. 470 (7332): 115–9...

ApoE was found in EVs secreted by astrocyte exposed to amyloid beta. An oncogenic mechanism illustrates how extracellular vesicles are produced by proliferative...

progenitor carcinoma stem cell can be formed from any of a number of oncogenic combinations of mutations in a totipotent cell, a multipotent cell, or...