DOSEN PROFIL LENGKAP

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in...

An Hsp90 inhibitor is a substance that inhibits that activity of the Hsp90 heat shock protein. Since Hsp90 stabilizes a variety of proteins required for...

of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. FNIP1 acts as a scaffold to load FLCN onto Hsp90. FNIP1 is also involved...

Stress-induced-phosphoprotein 1 also Hsp70-Hsp90 organising protein (Hop) is encoded in the human by the STIP1 gene. It functions as a co-chaperone which...

classified based on their observed molecular weights into Hsp60, Hsp70, Hsp90, Hsp104, and small Hsps. The Hsp60 family of protein chaperones are termed...

inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important...

which acts as co-chaperone of Hsp90 (heat shock protein 90). AHSA2 and the related AHSA1 belongs to the AHA (Activator of Hsp90 ATPase) family of stress-regulated...

cytoprotective response to promote stability to the proteome. HSPs (e.g. HSP70, HSP90, HSP60, etc.) are present under normal conditions but under heat stress...

named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins...

suggesting a genetic basis for those phenotypes. The authors hypothesized that Hsp90 (the gene mutated in hsp83), as a chaperone protein, plays a pivotal role...

Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene. This protein is highly similar to Cdc 37, a cell division cycle control...

The GHKL domain (Gyrase, Hsp90, Histidine Kinase, MutL) is an evolutionary conserved protein domain. It is an ATPase domain found in several ATP-binding...

mechanism of action of pimitespib involves inhibition of heat shock protein 90 (Hsp90). In June 2022, it received approval in Japan for gastrointestinal stromal...

The Hsp90 cis regulatory element is an RNA element (RNA thermometer) found in the 5' UTR of the Drosophila hsp90 mRNA. It is required for increased translational...

connectivity allows Hsp90 to function as a network hub linking diverse protein interaction networks. Within these networks Hsp90 primarily specializes...

benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. Hsp90 client proteins play important roles in the regulation...

Cell by Balch and co-workers on the finding that down-regulation of the Hsp90 co-chaperone Aha1 rescues misfolding of CFTR in cystic fibrosis to describe...

binding molecules that assist in protein folding mediated by Hsp70 and Hsp90. They are particularly essential in stimulation of the ATPase activity of...

survive (mutant tau protein maintenance) to heat shock protein 90 (HSP90) since HSP90 performs such function in cancer cells and its inhibition resulted...

Protein 90 (HSP90). HSP90 is key in protein folding and maturation. TopoTarget is currently looking for small molecule drugs that inhibit HSP90 function...

chaperone protein that in humans is encoded by the HSP90B1 gene. HSP90B1 is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical...

in the cytoplasm as an inactive protein complex consisting of a dimer of Hsp90, prostaglandin E synthase 3 (PTGES3, p23) and a single molecule of the immunophilin-like...

resorcinylic isoxazole amide Luminespib is an inhibitor of heat shock protein 90 (Hsp90), which is a chaperone protein that plays a role in the modification of...

monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation...

evolutionary capacitors is closely associated with the heat shock protein Hsp90. When Hsp90 is downregulated in the fruit fly Drosophila melanogaster, a broad...

(the Hsp70/Hsp90 Organizing Protein) can bind to both Hsp70 and Hsp90 at the same time, and mediates the transfer of peptides from Hsp70 to Hsp90. Hsp70 also...

modifications of the Hsp90 chaperone machinery has also explained the reasons for tumors sensitivity and selectivity towards the Hsp90 inhibitors. Mollapour's...

Autophagy Biogerontology DNA repair § Senescence and apoptosis Geroprotector Hsp90 Immunosenescence Invariant NKT (iNKT) cells Klotho (biology) § Effects on...

to the HGNC: HSP70 DnaJ (HSP40) HSPB (small heat shock proteins) HSPC (HSP90) chaperonins Chaperonins are characterized by their barrel-shaped structure...

cytoplasmic, microtubule-associated enzyme. HDAC6 deacetylates tubulin, Hsp90, and cortactin, and forms complexes with other partner proteins, and is...

acting as an evolutionary capacitor. She proposed that a heat shock protein, hsp90, may act in the same way, normally preventing phenotypic consequences of...

along with the 90 kDa heat shock protein and PTGES3 (P23 protein). As an Hsp90-associated co-chaperone that regulates the responsiveness of steroid hormone...

cytosol complexed with a variety of proteins including heat shock protein 90 (hsp90), the heat shock protein 70 (hsp70) and the protein FKBP4 (FK506-binding...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

cellular levels of the enzyme may be controlled by the molecular chaperone HSP90, which upon association with CYP2E1 allows for transport to the proteasome...

Stanford University Thesis Biochemical studies on protein folding chaperones : Hsp90 and cyclophilin; and, On trypanosomal enzymes : trypanothione and glutationylspermidine...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

leukemia or solid tumors, especially kidney tumors. It works by inhibiting Hsp90, which is expressed in those tumors. It belongs to the family of drugs called...

GTPases. Hamartin coded by the gene TSC1 functions as a facilitator of Hsp90 in chaperoning of tuberin, therefore preventing its ubiquitination and degradation...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

source] What AGR2 does in cancers is poorly understood. In breast cancer, HSP90 is a molecular chaperone expressed in tumor cells when there exists an excess...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

GRP94), an endoplasmic reticulum-resident protein chaperon belonging to the HSP90 family of heat shock proteins. His research revealed that gp96 is pivotal...

(APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67-phox, hsp90-binding immunophilins, transcription factors, the protein kinase R (PKR)...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

TKIs have been shown to deprive tyrosine kinases of access to the Cdc37-Hsp90 molecular chaperone system on which they depend for their cellular stability...

involved in DNA repair such as uracil-DNA glycosylase and DNA-PKcs and the Hsp90 molecular chaperone system. Although focussed on understanding basic mechanisms...

A strong interaction exists between PrP and the cochaperone Hop (Hsp70/Hsp90 organizing protein; also called STI1 (Stress-induced protein 1)). GRCh38:...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Pearl LH, Prodromou C (Dec 2002). "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1" (PDF). Mol. Cell. 10 (6): 1307–18...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

beneficial effects of these regimens. A recent study showed that blocking Hsp90 function with geldanamycin inhibits PostC protection and PKCε translocation...

phylogeny of diplomonads and enteromonads based on SSU rRNA, alpha-tubulin and HSP90 genes: Implications for the evolutionary history of the double karyomastigont...

Cycloproparadicicol as Synthetically Feasible Preclinical Anticancer Agent Based on Hsp90 as the Target". Journal of the American Chemical Society. 126 (25): 7881–9...

Imanishi Takeshi; Wada Youichiro; Kodama Tatsuhiko; Doi Takefumi (Jan 2002). "HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage...

proteins, including the tumor suppressors p53 and Rb, the molecular chaperone Hsp90, estrogen receptor α, and PARP1. This methylation affects the stability...

of precursor proteins to their destined mitochondrial subcompartments. HSP90 aids the delivery of the mitochondrial preprotein to the TOM complex in...

S phase KAP, Cks1, p27Kip1, and Spy-1 Cdk4 Cyclins D1, D2, D3 G1 phase HSP90-Cdc37 Cdk6 Cyclins D1, D2, D3 G1 phase p16INK4A, p19INK4D, and P18INK4C-cyclin...

environmental. For example, Drosophila fruit flies have a heat shock protein, Hsp90, which protects the development of many structures in the adult fly from...

Hernández MP, Chadli A, Toft DO (2002). "HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor". J. Biol. Chem. 277 (14):...

multimolecular chaperone complexes organized around the heat shock protein 90 (HSP90), containing p23 protein, and immunophilin, and located in majority in cytoplasm...

represent the AHR, red bars ARNT, yellow bars ARA9 (AIP, Xap2), blue bars HSP90, and the blue ovals p23. Dioxin binding to the AHR (1.) leads to its translocation...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine". Cell. 101 (2): 199–210. doi:10.1016/S0092-8674(00)80830-2...

RTA then undergoes triage by the cytosolic molecular chaperones Hsc70 and Hsp90 and their co-chaperones, as well as by one subunit (RPT5) of the proteasome...

M100200200. PMID 11297531. Wang C, Chen J (January 2003). "Phosphorylation and hsp90 binding mediate heat shock stabilization of p53". The Journal of Biological...

Wickner, S (2023). "Proteins form Binary Complexes with Hsp90 and Ternary Complexes with Hsp90 and Hsp70". J Mol Biol. 435 (17): 168–184. doi:10.1016/j...

the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating...

include bosutinib, bafetinib, Saracatinib(AZD-0530), XLl-999, KX01 and XL228. HSP90 inhibitor NVP-BEP800 has been described to affect stability of Src tyrosine...

fragment of a human monoclonal antibody. As such, it "grabs" onto fungal hsp90, hence its proposed trade name. Its ability to potentiate the effects of...

→ RNA → protein system. Examples of RNA thermometers include FourU, the Hsp90 cis-regulatory element, the ROSE element, the Lig RNA thermometer, and the...

affects transcription and translation by regulating heat-shock protein 90 (Hsp90). HDAC6 is required in the formation of stress granule (SG) proteins and...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

doi:10.1002/cber.187600902133. Sidera, K.; Patsavoudi, E. (January 2014). "HSP90 inhibitors: current development and potential in cancer therapy". Recent...

and target them for proteasomal degradation are expressed. Both Hsp27 and Hsp90—chaperone proteins have been implicated in increasing the activity of the...

SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional...

direct inhibition of IKKα and IKKβ kinases, inactivation of CDC37 and p23 (HSP90 chaperone proteins), suppression of proteasome function and activation of...

PMID 12885772. Loo MA, Jensen TJ, Cui L, et al. (1999). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its...

activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase...

HSF (heat shock family). HSF is constitutively bound by Hsp90. Upon a proteotoxic stimulus Hsp90 is recruited away from HSF, which can then bind to heat...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Hinagata J, Tanaka T, Imanishi T, Wada Y, Kodama T, Doi T (January 2002). "HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage...

"Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway". PLOS Biology. 17 (3) e2006966. doi:10.1371/journal.pbio.2006966...

Derris robusta. Recent research indicates that it acts as an inhibitor of Hsp90 to its function as a chaperone protein. East AJ, Ollis WD, Wheeler RE (1969)...

(gene), encoding the homeodomain-only protein Hop (protein), the Hsp70-Hsp90 organizing protein Hubble Origins Probe, or HOP, a proposed orbital telescope...

complex, and involves a number of membrane-associated proteins alongside the HSP90 Cdc37 molecular chaperone complex. PSKH2 exhibits significant sequence homology...

of inactive HSF1 from complexes with heat shock proteins Hsp40/Hsp70 and Hsp90. With help from the ncRNA hsr1, HSF1 then trimerizes, becoming active and...

repressed by interaction with chaperones such as heat shock proteins Hsp70 and Hsp90, and TRiC/CCT. In the event of proteotoxic stress such as heat shock, these...

HSP90AA2, is a human gene. The protein encoded by this gene belongs to the Hsp90 family of heat shock proteins. Ozawa K, Murakami Y, Eki T, Soeda E, Yokoyama...

(2007). "Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes". J. Biol. Chem. 282 (16): 11795–804. doi:10.1074/jbc.M610430200...

tumorigenesis. Thus, inhibition of Hsp90 leads to cellular degradation of target oncoproteins. Accordingly, inhibition of the Hsp90 chaperone machinery is a potential...

neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation"...

"Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin". The Journal...

have also been reported. For nonsmall-cell lung cancer, HSP27, HSP70, and HSP90 inhibitors are under investigation in clinical trials. In addition, treatment...

PPID in particular helps chaperone the assembly of heat shock protein Hsp90, as well as the nuclear localization of glucocorticoid, estrogen and progesterone...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

now lays a particular emphasis on small heat shock proteins (sHsps), the Hsp90 chaperone machinery and the role of molecular chaperones in antibody folding...

(June 1996). "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4". Genes & Development. 10 (12): 1491–1502...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

treat melanoma CDK inhibitors, e.g. PD-0332991, LEE011 in clinical trials Hsp90 inhibitors, some in clinical trials Hedgehog pathway inhibitors (e.g. FDA...

Archived from the original on 2012-04-16. Retrieved 2012-04-17. "Exelixis HSP90 inhibitor XL888". Archived from the original on 2016-09-18. Retrieved 2016-09-16...

Lundsten S, Spiegelberg D, Stenerlöw B, Nestor M (December 2019). "The HSP90 inhibitor onalespib potentiates 177Lu‑DOTATATE therapy in neuroendocrine...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist...

Later, the same organism was examined under electron microscopy and its Hsp90 gene was sequenced. Combining the newly obtained morphological and genetic...

1 forms multiple small highly mobile aggregates. However, proteasome or Hsp90 inhibition rapidly triggered their translocation into the aggresome, and...

respectively. Macbecins mechanism of action is in part due to heat shock protein Hsp90 protein inhibition. Tanida S, Hasegawa T, Higashide E (February 1980). "Macbecins...

post-transcriptional modifications of Pim-1, it has been hypothesized that Hsp90 is responsible for the folding and stabilization of Pim-1, although the...

in L. interrogans. HtpG is a molecular Chaperone homologous to bacterial Hsp90 and is highly conserved in Leptospira species, including L. interrogans...

S2CID 35809820. Shen, C; Liu, CW; Liu, L. "Heat-induced stress genes Hsp70, Hsp90 and chloroplast psaA and psbA gene expressions of Galaxea astreata endosymbiotic...

reason why evolution cannot tend towards simplicity. Inhibition of the HSP90 protein has a dramatic effect in the development of the blind tetra. The...

probably not be used for reference purposes: GUSB, RPLP0, TFRC, GAPDH, HSP90, and β-actin. Although they were once considered as "housekeeping genes...

at lower temperatures. Cyanobacterial RNA thermometer FourU thermometer Hsp90 cis-regulatory element Chowdhury S, Maris C, Allain FH, Narberhaus F (2006)...

can function. Inhibiting protein quality-control factors such as VCP and HSP90 has been shown experimentally to increase mutant ZIP13 protein levels and...

Phosphorylated CAR forms a multiprotein complex with the heat shock protein 90 (hsp90) and the cytoplasmic CAR retention protein (CCRP) which keep CAR in the...

reference expression data Gene ontology Molecular function nucleotide binding Hsp90 protein binding spectrin binding protein binding identical protein binding...

translocates the catalytic domain to the cytosol by interaction with cytosolic Hsp90 and thioredoxin reductase. This single chain recombinant immunotoxin selectively...

of newly synthesised p21 termed it Wisp39. It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling...

monooxygenase activity estrogen 16-alpha-hydroxylase activity Hsp70 protein binding Hsp90 protein binding Cellular component cytoplasm organelle membrane endoplasmic...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

oligonucleotide that targets CLU mRNA. It was shown to improve the activity of HSP90 inhibitors by suppressing the heat shock response in castration-resistant...

Tony; Erdjument-Bromage, Hediye; Chomet, Max (2013-10-17). "Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies"...

Liebig-Vereinigung für Chemie, the 4th International Conference on the Hsp90 Chaperone Machine (2008). The project Science Comment has been established...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

1980) MRC Laboratory (Postdoctoral, 1981–82) Known for Protein Folding, Hsp90 Scientific career Fields Biophysics Biochemistry Cell Biology Workplaces...

More reference expression data BioGPS n/a Gene ontology Molecular function Hsp90 protein binding NAD-dependent histone deacetylase activity (H3-K14 specific)...

Jin has shown that the quality of neurons is evaluated by the EBAX-1 and hsp90, which serve to identify defects and fix any flaws. Jin has investigated...

Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition. Adv. Synth. Catal., 350: 1677–1681. doi:10.1002/adsc.200800187...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90". Molecular Cell. 9 (2): 401–10. doi:10.1016/S1097-2765(02)00450-1. PMID 11864612...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

the binding/entry of the truncated capsid protein, which indicates that Hsp90 plays an important part in HEV transport. In terms of the diagnosis of hepatitis...

in regulation of apoptosis. This localization is aided by the chaperone Hsp90, which is required to stabilize the protein during the transit. HGTD-P primarily...

dissociation of Hsp90 is required for this process, Hsp90s initial interaction is critical for PIDD1’s function. Interruption of the Hsp90-PIDD1 complex...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

anticancer agents through clinical development: heat shock protein 90 (Hsp90) inhibitors and epothilones. Their technology platform was based on manipulation...

cytoplasmic tail is shuttled to the mitochondria through interaction with hsp90. This interaction is induced through phosphorylation of the MUC1 cytoplasmic...

More reference expression data BioGPS n/a Gene ontology Molecular function Hsp90 protein binding cysteine-type peptidase activity metal ion binding Lys48-specific...

families, based on sequence homology and molecular weight (hsp110, hsp100, hsp90, hsp70, hsp60, hsp40, hsp10, and small hsp families). Proteins are highly...

C5SD inactivation is dependent on the activity of the chaperone protein Hsp90 and the phosphatase calcineurin. However, the clinical relevance of this...

1998). "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1". Cell. 94 (4):...

Kazlauskas A, Sundström S, Poellinger L, Pongratz I (April 2001). "The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor"...

of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90". J. Biol. Chem. 273 (29): 18007–10. doi:10.1074/jbc.273.29.18007. PMID 9660753...

Y, de Lange T, Pavletich NP (2010). "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes". Genes Dev. 24 (18): 2019–2030...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90". Int J Mol Med. 27 (3): 441–446. doi:10.3892/ijmm.2011.601. PMID 21249311...

Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi:10.1074/jbc.M300788200...

domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine". Cell. 101 (2): 199–210. doi:10.1016/S0092-8674(00)80830-2...

PMID 12477932. Young JC, Hoogenraad NJ, Hartl FU (2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70"...

known to be a part of stress respons, since it interacts with chaperone HSP90. GRCh38: Ensembl release 89: ENSG00000116161 – Ensembl, May 2017 GRCm38:...

depend on heme, but rather relies on the help of two heat shock proteins (HSP90 and HSP70). HRI is mainly found in the precursors of red blood cells, and...

closely related secretory-pathway Ser/Thr kinase PSKH1 is a client of the HSP90 molecular chaperone system in human cells. Kinase Pseudoenzyme Phosphatome...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

"Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines". Bone. 39 (4): 739–53. doi:10.1016/j.bone...

Studies of the von Hippel-Lindau Tumor Suppressor and the Oncogene Chaperone Hsp90 Archived 2014-04-07 at the Wayback Machine, completed in the laboratory...

PMC 2856985. PMID 20157113. French, J. B.; et al. (2013-01-28). "Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome". Proceedings...

Manuj; Thomas, Bobby; Chinta, Shankar J.; Andersen, Julie K. (March 2018). "Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization...

with chaperone proteins such as heat shock protein 70 and 90 (Hsp70 and Hsp90). Tamoxifen binds to Cre-ER and disrupts its interactions with the chaperones...

Bencsura A, Vu HA (2006). "F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes". Biochem. Biophys. Res. Commun. 345 (1): 419–29...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

et al. (September 2003). "Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma". Cancer. 98 (5): 970–7. doi:10.1002/cncr...

expression signature-based chemical genomic prediction identifies novel class of HSP90 pathway modulators". Cancer Cell. 10 (4): 321–30. Peng, XP; Lim, S; Li,...

ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding". J. Biol. Chem. 281 (45): 34592–600. doi:10.1074/jbc.M604019200...

BioGPS More reference expression data Gene ontology Molecular function Hsp90 protein binding nucleotide binding Hsp70 protein binding protein binding...

"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90". Molecular Cell. 9 (2): 401–10. doi:10.1016/s1097-2765(02)00450-1. PMID 11864612...

C-terminus of the eukaryotic Hsp90 protein (high micromolar IC50). Modification of the novobiocin scaffold has led to more selective Hsp90 inhibitors. Novobiocin...

protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid...

CatSperβ, CDC2, CHCHD3, DNAJC7, DNAJC8, DNAJC9, FOXP3, HDAC4, HOPX, HSP40, HSP90, HSP105, IRAK1BP1, METTL21A, NAA10, NEDD1, NOD2, PPP5C, PKRN, SMAD3, STUB1...

kDa (Hsp40), the heat shock protein of 90 kDa (Hsp90), the hsc70-interacting protein (HIP), the hsc70-hsp90 organizing protein (HOP), and the Bcl2-associated...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

vaporization - heat shock protein - Hsp70 (70 kDa heat shock proteins) - Hsp90 (90 kDa heat shock proteins) - heavy-chain immunoglobulin - Hela cell -...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

conferred by its kinase domain and is mediated by the chaperone protein Hsp90". The Journal of Biological Chemistry. 276 (5): 3702–3708. doi:10.1074/jbc...

cancer. Altieri has also been involved in the development of gamitrinib, a Hsp90 inhibitor that was shown to disable the activity of mitochondria in cancerous...

𝛽-tubulin, 𝛾-tubulin, EF-1𝛼, EF-2, cytHSP70, ubiquitin, 18S rRNA, and HSP90 allow the placement of oxymonads near diplomonads and trichomonads, with...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Robert (2014). "High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors". Biology. 3 (1): 101–138. doi:10.3390/biology3010101. PMC 4009755...

magnesium ion binding hydrolase activity Hsp70 protein binding kinase activity Hsp90 protein binding catalytic activity endonuclease activity ATP binding enzyme...

survival of cancer cells, in particular, molecular chaperones such as Hsp90. The leading Hsp90 inhibitor was discovered by Workman's team at ICR in collaboration...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

studies; administering geldanamycin (an antitumor antibiotic that acts on Hsp90) to mutant flies before symptoms of neural decline were visible averted...

1998). "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1". Cell. 94 (4):...

translation takes place. RNA thermometer ROSE element FourU thermometer Hsp90 cis-regulatory element Cyanobacterial RNA thermometers Kortmann J, Sczodrok...

Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi:10.1074/jbc.M300788200...

Most microvesicles contain the so-called "heat-shock proteins" hsp70 and hsp90, which can facilitate interactions with cells of the immune system. Finally...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

mediate protein-protein interaction and can be found in co-chaperones of Hsp90. Therefore, a role of EMC2 in mediating interactions with cytosolic chaperones...

Helicase II Hsp27 HIP1 (Huntingtin Interacting protein 1) Hsp70 Histactophilin Hsp90 Histidine rich protein II Hsp100 Inhibitor of apoptosis (IAP) Insertin Interaptin...

Kazlauskas A, Sundström S, Poellinger L, Pongratz I (April 2001). "The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor"...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist...

antibody. Another receptor that can be bound is heat shock protein 90 (HSP90) on the surface of the DF-1 cell membrane. Although, this receptor will...

Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells". Cells. 9 (3): 755. doi:10.3390/cells9030755....

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

dynactin binding receptor ligand activity protein phosphatase 2A binding Hsp90 protein binding minor groove of adenine-thymine-rich DNA binding double-stranded...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

mechanism. Examples include: ACTR, cMyb, E2F1, EKLF, FEN 1, GATA, HNF-4, HSP90, Ku70, MKP-1, NF-κB, PCNA, p53, RB, Runx, SF1 Sp3, STAT, TFIIE, TCF, YY1...

combination of EGFR and MET kinase inhibitors, and Hsp90 inhibitors (EGFR and MET both require Hsp90 proteins to fold properly). In addition, taking repeated...

Miller A, Lin Y, Rodriguez Y, Neckers L, et al. (April 2000). "Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting...

Medical College. His areas of research include PI3K, the androgen receptor, HSP90, and immunotherapy. Scher is on the board of directors at Asterias, a biotechnology...

expression data BioGPS n/a Gene ontology Molecular function iron ion binding Hsp90 protein binding calcium ion binding phosphoprotein phosphatase activity...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

H. W.; Šenolt, Ladislav; Bečvář, Radim; Tomčík, Michal (2021). "Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin...

metabolism. The genes under positive selection pressure include CYP1A1 and Hsp90, which are involved in the metabolism of foreign substances and drugs. High...

is an effective inhibitor of breast cancer growth in vivo. LMTK3 is an HSP90-CDC37 client protein which requires this interaction for folding and stability...

endodeoxyribonuclease activity protein kinase binding supercoiled DNA binding DNA binding Hsp90 protein binding microtubule binding protein kinase A binding RNA binding...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

expression data Gene ontology Molecular function molecular adaptor activity Hsp90 protein binding protein binding protein kinase binding protein-containing...

VIIa, Fibronectin, Gentamicin, GIPC1, Heat shock proteins: gp96, hsp70, hsp90, heparin cofactor II, Hepatic lipase, ITGB1BP1, Lactoferrin, Lipoprotein...

drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its...

cholerae virulence. Other known RNA thermometers include the ROSE element and Hsp90 cis-reg element. Hairpin II appears to be a dynamic feature of FourU's secondary...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Decastava; Scytomonas saepesedens; Entosiphon oblongum), Hsp90 introns, and putative euglenoid Hsp90 pre-mRNA insertional editing". European Journal of Protistology...

Lizee G, Hanash SM, Proia D, Amaria R, Davis RE, Hwu P (September 2017). "HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response...

Young JC, Hoogenraad NJ, Hartl FU (January 2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70"...

Gesslbauer B, Rek A, Kungl AJ (July 2007). "A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome". Proteomics. 7 (14): 2375–83. doi:10...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

GTPases to regulate the actin cytoskeleton. GNA12 also interacts with PPP5C, HSP90, Resistance to inhibitors of cholinesterase-8A (Ric-8A) and TEC. G12/G13...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

lipoprotein. In a study by Lee et al., higher expression level of hnRNP A2/B1 and Hsp90 were observed in human hepatoma HepG2 cells than in wild type cells. This...

stimulus. Specifically, a seven amino acid peptide, termed TAT-εHSP90, homologous to the Hsp90 sequence within the PKCε C2 domain induced translocation of...

studies have suggested that NLRP3 is kept in an inactive state complexed with HSP90 and SGT1 in the cytoplasm. Under certain circumstances, NLRP3 can be primed...

BioGPS More reference expression data Gene ontology Molecular function Hsp90 protein binding protein domain specific binding zinc ion binding protein...

three novel series of anti-cancer drugs to major pharmaceutical companies: Hsp90 inhibitors to Novartis, PKB inhibitors to AstraZeneca and PI3Kinase inhibitors...

interactions and GPCRs, leading to clinical candidates for targets such as Chk1, Hsp90, Bcl-2, Mcl-1, FAAH and A2A. As well as an internal portfolio of drug discovery...

A, Vu HA (June 2006). "F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes". Biochemical and Biophysical Research Communications...

(CD11a) psoriasis (blocks T-cell migration) Efungumab Mycograb scFv human Hsp90 invasive Candida infection Eldelumab mab human CXCL10 (IP-10) Crohn's disease...

Gene ontology Molecular function transferase activity nucleotide binding Hsp90 protein binding protein kinase activity protein N-terminus binding protein...

sirolimus (rapamycin) (a mTOR inhibitor) Radicicol and the pochonin family (HSP90 inhibitors) The cholesterol lowering agent lovastatin Discodermolide Aflatoxin...

R, Pratt WB (October 1993). "Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system". J. Biol. Chem...

IRF-1 activity. IRF1 has been shown to interact with: CHIP GAGE HSP70 / HSP90 IRF8 KPNA2 MYD88 PCAF STAT1 TAT VEGFR2 REDD2 IRF2 Interferon regulatory...

"Heterozygous yeast deletion collection screens reveal essential targets of Hsp90". PLOS ONE. 6 (11) e28211. Bibcode:2011PLoSO...628211F. doi:10.1371/journal...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

(2011). "Calcium/calmodulin kinase1 and its relation to thermotolerance and HSP90 in Sporothrix schenckii: an RNAi and yeast two-hybrid study". BMC Microbiol...

In addition to these phosphatases, other molecular components such as Hsp90-Cdc37 chaperone complex can also modulate p38 MAPK autophosphorylation activity...

acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit". Archives...

Chromatography: Comparison with Established Techniques for Screening against HSP90". Analytical Chemistry. 85 (14): 6756–6766. doi:10.1021/ac400715t. PMID 23806099...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

has helped identify heat shock proteins such as the endoplasmic reticulum hsp90 family member gp96 as a cancer vaccine, participated in the identification...

more function of reptin is its interaction with heat shock protein 90 (HSP90), where it forms the complex, R2TP. This complex functions mainly in processing...

definition reported cases of transvection between different alleles of Hsp90. This second definition is also sometimes applied to the situation where...

Dai K, Chen PL, Riley DJ, Lee WH (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein...

Lin X, Feng XH (Jul 2008). "Critical regulation of TGFbeta signaling by Hsp90". Proceedings of the National Academy of Sciences of the United States of...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

may have some impact on its therapeutic effects in canine mastocytoma. HSP90 inhibitor NVP-BEP800 has been described to affect stability of the LCK kinase...

several different heat shock proteins. These include Hsp83, a homolog of Hsp90. A regulatory element in the 3' UTR of Hsp83 controls translation of Hsp83...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein". Molecular & Cellular Proteomics...

1007/s12257-008-0102-8. Chen X.J., Wu M.J., Jiang Y., Yang Y., Yan Y.B. Dunaliella salina Hsp90 is halotolerant. Int. J. Biol. Macromol. 2015;75:418–425. doi: 10.1016/j...

receptors are closely related to chaperones (namely heat shock proteins hsp90 and hsp56), which are required to maintain their inactive (but receptive)...

instance, the monomethylation of HSP90 lysine 616 by Smyd2, and its reversal by LSD1, regulate enzymatic activity of HSP90. Nitika; Porter, Corey M.; Truman...

data BioGPS n/a Gene ontology Molecular function Hsp70 protein binding Hsp90 protein binding actin binding alpha-tubulin binding chaperone binding G...

Jacquel A, et al. (2008). "Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell...

has been shown to bind the heat shock protein Hsp72. Hsp72 together with Hsp90 form a heterocomplex with the estrogen receptor. Hence AFPep through interaction...

Lin X, Feng XH (July 2008). "Critical regulation of TGFbeta signaling by Hsp90". Proceedings of the National Academy of Sciences of the United States of...

"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90". Mol. Cell. 9 (2): 401–10. doi:10.1016/S1097-2765(02)00450-1. PMID 11864612...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

directly inhibits HSP90, a cell protector hijacked by cancer to avoid being attacked by the immune system. Thus, by inhibiting HSP90, EnnA allows the immune...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Nature Biotechnology 37.4 (2019): 436–444. Kishinevsky, Sarah, et al. "HSP90-incorporating chaperome networks as biosensor for disease-related pathways...

interaction between JMJD1C with JMJD1c's partner proteins, for example, MDC1 and HSP90.[citation needed] GRCh38: Ensembl release 89: ENSG00000171988 – Ensembl...

activity. It acts as a competitive inhibitor and specifically inhibits Hsp90 and TopII. Novobiocin has been investigated and used in metastatic breast...

alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of...

of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex". The Journal of Biological Chemistry. 269 (15):...

Wang, J., Huang, A. X., and Lin, H. (2010) Drosophila Piwi Functions in Hsp90-Mediated Suppression of Phenotypic Variation. Nature Genetics 43, 153–158...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Tsuruo T (Sep 2000). "Modulation of Akt kinase activity by binding to Hsp90". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10832–7. Bibcode:2000PNAS...9710832S...

The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. doi:10.1128/MCB...

Digwal CS, Trepel JB, Neckers L. Structural and functional complexity of HSP90 in cellular homeostasis and disease. Nat Rev Mol Cell Biol. 2023 Nov;24(11):797-815...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Browser. Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW (2007). "Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Decastava; Scytomonas saepesedens; Entosiphon oblongum), Hsp90 introns, and putative euglenoid Hsp90 pre-mRNA insertional editing". European Journal of Protistology...

(2003). "Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein"...

Lyn activation has been shown to reduce pulmonary mucus hypersecretion. HSP90 inhibitor NVP-BEP800 has been reported to affect Lyn kinase stability and...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Jensen TJ, Cui L, Hou Y, Chang XB, Riordan JR (1998). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its...

PMID 10931946. Shao J, Grammatikakis N, Scroggins BT, et al. (2001). "Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

from the original on 2022-09-12, retrieved 2022-09-12 "AIPL1 AIP like 1 HSP90 co-chaperone [Homo sapiens (Human)] - Gene - NCBI". www.ncbi.nlm.nih.gov...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

reference expression data Gene ontology Molecular function transferase activity Hsp90 protein binding nucleotide binding protein kinase activity growth factor...

protein binding histone acetyltransferase binding protein kinase binding Hsp90 protein binding sequence-specific DNA binding DNA binding transcription...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

receptor, forms a complex consisting of itself, heat shock proteins (hsp70, hsp90) and immunophilins. Upon activation, due to hormone binding to ligand binding...

complex. Assembly and disassembly of CMA translocation complex is mediated by hsp90 and hsc70 chaperones, respectively. Degradation of LAMP-2A monomers at the...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines". Jpn. J. Cancer Res. 90 (1): 60–8. doi:10...

EE, Richardson RT, O'Rand MG (January 2005). "Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

(2012-03-01). "The HSP90 complex of plants". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Heat Shock Protein 90 (Hsp90). 1823 (3): 689–697...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Garrido C (May 2008). "Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell...

Tahbaz N, López-Orozco J, LaPointe P, Lasko P, Hobman TC (July 2009). "Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

L.; Niedernhofer, Laura J.; Robbins, Paul D. (2017). "Identification of HSP90 inhibitors as a novel class of senolytics". Nature Communications. 8 (1):...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit". Archives...

PMC 108906. PMID 9584165. Liu YV, Semenza GL (March 2007). "RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization". Cell Cycle...

Prodromou C, et al. (June 2016). "The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding". Nature Communications. 7 12037...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

ontology Molecular function transferase activity protein kinase activity Hsp90 protein binding nucleotide binding protein homodimerization activity kinase...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Lillard-Wetherell K, Tahmaseb K, et al. (May 2009). "Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized...

Freeman, B.C.; Morimoto, R.I. (1996). "The Human Molecular Chaperones HSP90, HSP70 (HSC70) and HDJ-1 have Distinct Roles in Recognition of a Non-native...

complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins". The Journal of Biological Chemistry. 278 (31): 28490–500...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

various proteins from the two-hybrid screening method. Interactions with Hsp90 co-chaperone (CDC37), and spermatid associated protein (SPERT) have been...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

"Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system". EMBO J. 22 (14): 3613–23. doi:10.1093/emboj/cdg362. PMC 165632...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

surface exposed DAMPs are heat-shock proteins (HSPs), namely HSP70 and HSP90, which under stress condition also translocate to the plasma membrane. On...

Candida albicans fungus was tied to the function of heat-shock protein 90 (Hsp90). In 2012, Cowen was appointed a Canada Research Chair (CRC) in Microbial...

serine/threonine kinase activity microtubule binding tau protein binding Hsp90 protein binding voltage-gated calcium channel activity involved in positive...

Hall C, Hu J, Greer PA (August 2016). "Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis". Molecular and Cellular...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

More reference expression data BioGPS n/a Gene ontology Molecular function Hsp90 protein binding SH2 domain binding chromatin binding thyroid hormone receptor...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

reference expression data Gene ontology Molecular function DNA binding Hsp90 protein binding protein dimerization activity DNA-binding transcription...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

Baudoin-Legros M, Dadlez M, Edelman A, et al. (January 2006). "Association between Hsp90 and the ClC-2 chloride channel upregulates channel function". American Journal...

BioGPS More reference expression data Gene ontology Molecular function Hsp90 protein binding protein dimerization activity DNA-binding transcription...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

activity mitogen-activated protein kinase kinase binding chaperone binding Hsp90 protein binding 14-3-3 protein binding Cellular component cytoplasm cytosol...

Domain 15 (SAMD15), VPS33B Interacting Protein (VIPAS39), and Activator of HSP90 ATPase Activity 1 (AHSA1). NOXRED1 has three known mRNA isoforms (table...

C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron...

(2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone". Biochem. Biophys. Res. Commun. 348 (4): 1429–35. doi:10.1016/j...