DOSEN PROFIL LENGKAP

A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a...

Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in 1990 in the lab of Roger D. Kornberg...

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is...

CREB regulated transcription coactivator (CRTC) may refer to the following proteins and genes: CRTC1 CRTC2 CRTC3 CREB CRTC (disambiguation) This disambiguation...

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified...

The nuclear receptor coactivator 1 (NCOA1), also called steroid receptor coactivator-1 (SRC-1), is a transcriptional coregulatory protein that contains...

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid...

previously unidentified coactivators necessary for receptor-dependent gene transcription. In 1995, he successfully cloned the first coactivator, SRC-1, marking...

receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene. The protein encoded by this gene is a transcriptional coactivator that can...

FRY like transcription coactivator is a protein that in humans is encoded by the FRYL gene. GRCh38: Ensembl release 89: ENSG00000075539 – Ensembl, May...

Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal...

to the dimerization interface of the receptor and in addition, binds coactivator and corepressor proteins. The LBD also contains the activation function...

agonist) AF-2 binds either the N-terminal FXXFL motif intramolecularly or coactivator proteins (containing the LXXLL or preferably FXXFL motifs) A ligand dependent...

The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): p300 (also known...

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene. PPARGC1A Peroxisome...

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5...

interact with a number of coactivators. Coactivators are not just protein partners that connect sites together in a complex. Coactivators play an active role...

Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded...

or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3....

(LEDGF/p75), dense fine speckles 70kD protein (DFS 70) or transcriptional coactivator p75/p52, is a protein that in humans is encoded by the PSIP1 gene. PSIP1...

Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors. The mechanism of...

humans is encoded by the POU2AF1 gene. The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and,...

peroxisome proliferator-activated receptor delta GW501516 PPAR gamma coactivator 1-alpha estrogen-related receptor γ/α GSK4716 SLU-PP-332 NFE2L2 Canonical...

identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex". Molecular and Cellular Biology. 33 (8): 1487–502. doi:10.1128/MCB...

smooth muscle cell and cardiac muscle cell-specific transcriptional coactivator of serum response factor (SRF). When expressed in smooth muscle precursor...

Nuclear receptor coactivator 7 is a protein that in humans is encoded by the NCOA7 gene. Transcription coregulator GRCh38: Ensembl release 89: ENSG00000111912...

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. CRTC2, initially called TORC2...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator binding Cellular component Cry-Per complex nucleus nuclear speck Biological...

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans...

p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5). United States: 1137–49. doi:10...

cell specificity after they demonstrate that the coactivator OCA-B, the first cell-specific coactivator, discovered by Roeder in 1992, is unique to immune...

humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator. The activation of gene transcription is a multistep process that is...

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene. The protein encoded...

K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53. Several domains of PCAF can act independently or...

CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is an enzyme (EC 2.1.1.125)...

2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Mol. Cell. Biol. 22 (21): 7688–700. doi:10...

histone acetylase activity of CBP/p300 coactivators. PRMT4 recruitment of chromatin by binding to coactivators increases histone methylation and enhances...

with resistance to endocrine therapy, especially aromatase inhibitors. Coactivators of ER-α include: SRC-1 AIB1 – amplified in breast 1 PELP-1 – Proline-...

Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene. It plays...

PPARγ. In rats, binding of GW501516 to PPARδ recruits the coactivator PGC-1α. The PPARδ/coactivator complex in turn upregulates the expression of proteins...

found to play a role in cancer and diabetes. TCF/LEF factors recruit the coactivator beta-catenin to enhancer elements of genes they target. They can also...

Dailey GM, Fang Q, et al. (December 2021). "Structure of the human SAGA coactivator complex". Nature Structural & Molecular Biology. 28 (12): 989–996. doi:10...

"Differential use of functional domains by CoCoA in its synergistic coactivator function with β-catenin or GRIP1". J. Biol. Chem. 281 (6): 3389–97. doi:10...

Peterson VJ, Nevrivy DJ, Leid M (December 1997). "p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha". The Journal...

domain contains the ligand binding cavity as well as binding sites for coactivator and corepressor proteins. The E-domain in the presence of bound ligand...

(October 2004). "Biological control through regulated transcriptional coactivators". Cell. 119 (2): 157–67. doi:10.1016/j.cell.2004.09.037. PMID 15479634...

HIC-5 (Hydrogen Peroxide-Inducible Clone-5) or ARA55 (Androgen Receptor Coactivator 55kDA). As its multiple names suggests, TGFB1I1 a protein whose expression...

Wts can then go on to phosphorylate and inactivate the transcriptional coactivator Yorkie (Yki). Yki is unable to bind DNA by itself. In its active state...

(Jul 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell. 114 (2): 255–66...

upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation...

dysplasia–cleft syndrome 3/Limb–mammary syndrome/OFC8 Transcription coregulators Coactivator: CREBBP Rubinstein–Taybi syndrome Corepressor: HR (Atrichia with papular...

CLL/lymphoma 9, B cell CLL/lymphoma 9, transcription coactivator, BCL9 transcription coactivator External IDs OMIM: 602597; MGI: 1924828; GeneCards: BCL9...

E2A, HSF1, NF-IL6, NFAT1 and NF-κB interact directly with the general coactivators TAF9 and CBP/p300. p53 9aaTADs interact with TAF9, GCN5 and with multiple...

reference expression data Gene ontology Molecular function transcription coactivator activity transcription corepressor activity proline-rich region binding...

in humans and Zfpm1 and Zfpm2 genes in mice. Its members may act as coactivators and/or corepressors to modulate the activity of GATA transcription factors...

M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986...

transcription corepressor activity nuclear receptor coactivator activity transcription coactivator activity RNA binding RNA polymerase II cis-regulatory...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity transcription factor binding protein kinase B binding NF-kappaB...

Mediator is a multiprotein complex that functions as a transcriptional coactivator. The Mediator complex is required for the successful transcription of...

syndrome, is caused by a mutation in the CGI-58 protein. CGI-58 is a coactivator of ATGL, and together these proteins sustain blood lipid levels between...

are grouped into classes based on their DBDs. Other proteins such as coactivators, chromatin remodelers, histone acetyltransferases, histone deacetylases...

alpha,[unreliable source?] DDX17,[unreliable source?] Nuclear receptor coactivator 2,[unreliable source?] and SPEN. The SRAP has been shown to interact...

not be corrected by supplementation with any coactivators known at the time, nor was the absent coactivator protein characterized, which left some in the...

RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded...

from the receptor/DNA complex. Coactivator proteins are recruited, forming a DNA/TR/coactivator complex. One coactivator recruited to the site is nuclear...

II cis-regulatory region sequence-specific DNA binding transcription coactivator activity chromatin binding protein binding nucleosomal DNA binding Cellular...

(February 1999). "The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily". Molecular and Cellular...

eukaryotic transcriptional coactivators CBP and P300. It serves as a docking site for the formation of heterodimers between the coactivator and specific transcription...

L, et al. (2007). "The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis...

binding transcription factor binding GAF domain binding transcription coactivator activity aryl hydrocarbon receptor binding peptidyl-prolyl cis-trans...

reference expression data Gene ontology Molecular function transcription coactivator activity sequence-specific DNA binding DNA binding transcription corepressor...

have been found to be coactivator interaction inhibitors, which interfere with the interaction between TR receptors and coactivator proteins such as nuclear...

reference expression data Gene ontology Molecular function transcription coactivator activity DNA-binding transcription factor activity DNA binding Cellular...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity cytokine receptor activity protein kinase binding cytokine binding...

and humans. Peroxisome proliferator activated receptor gamma 1-alpha coactivator (PGC-1 alpha) is a specific myokine since it regulates kynurenine metabolism...

transcription enhancer factor). Here, it serves as a scaffold and recruits the coactivators p300 and LSD1, in addition to several corepressors which include G9a...

reference expression data Gene ontology Molecular function transcription coactivator activity hydrolase activity phosphatidate phosphatase activity molecular...

co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes...

cis-regulatory region sequence-specific DNA binding protein binding transcription coactivator binding DNA binding, bending RNA binding sequence-specific DNA binding...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

para-neoplastic Ma (PNMA). It is a ligand-dependent nuclear receptor transcription coactivator. Its zinc finger domain is CCHC which binds to zinc ion (see protein...

TFIIF, and TFIIH. Additional regulatory complexes (such as the mediator coactivator and chromatin remodeling complexes) may also be components of the PIC...

bind to the coregulator binding region of the ERα and inhibit the ERα/coactivator interaction, although its precise binding site and mode of action have...

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene. PNRC1 functions as a coactivator for several nuclear receptors...

that in humans is encoded by the KMT2A gene. It is a transcriptional coactivator and histone methyltransferase whose SET domain catalyses methylation...

that exhibit HAT activity. These include p300/CBP, nuclear receptor coactivators (e.g., ACTR/SRC-1), TAFII250, TFIIIC, Rtt109, and CLOCK. p300/CBP are...

histone demethylase activity signaling receptor activity transcription coactivator activity demethylase activity oxidative RNA demethylase activity P-TEFb...

encoded by the TAF7 gene. The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on...

expression data Gene ontology Molecular function RNA binding transcription coactivator activity protein binding Cellular component heterochromatin preribosome...

HJ, Lee SK, Kim TS, Lee JW, Lee YC (July 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol...

repression, or suppression – decrease the rate of gene transcription coactivator – a protein (or a small molecule) that works with transcription factors...

dysplasia–cleft syndrome 3/Limb–mammary syndrome/OFC8 Transcription coregulators Coactivator: CREBBP Rubinstein–Taybi syndrome Corepressor: HR (Atrichia with papular...

polymerase I core promoter sequence-specific DNA binding transcription coactivator activity p53 binding Tat protein binding protein binding nucleosomal...

Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor"...

2005). "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator". Endocrinology. 146 (9): 3892–9. doi:10.1210/en.2004-1513. PMID 15919756...

the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Aside from RARs, RXRA is also...

acid phosphatase, a metalloenzyme involved in bone formation Mediator (coactivator) or thyroid hormone receptor-associated proteins TNF-related activation...

and silencers. The LCR functions by recruiting chromatin-modifying, coactivator, and transcription complexes. Its sequence is conserved in many vertebrates...

Molecular function protein kinase binding 7SK snRNA binding transcription coactivator binding cyclin-dependent protein serine/threonine kinase regulator activity...

MUC-1 contribute to the formation of mucin. MUC-1 is a transcriptional coactivator involved in the activity and stabilization of enzymes and transcription...

activity protein binding enzyme binding RNA binding nuclear receptor coactivator activity Cellular component cytoplasm nucleoplasm DBIRD complex mitochondrial...

expression data Gene ontology Molecular function DNA binding transcription coactivator activity histone binding metal ion binding protein binding nucleic acid...

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans...

function ubiquitin protein ligase activity myosin binding transcription coactivator activity zinc ion binding Tat protein binding metal ion binding ubiquitin-protein...

interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63. Bibcode:1998BBRC..253...

"Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands". Biochemistry. 40 (23): 6756–6765. doi:10.1021/bi010379h...

(May 2003). "Actin dynamics control SRF activity by regulation of its coactivator MAL". Cell. 113 (3): 329–342. doi:10.1016/S0092-8674(03)00278-2. PMID 12732141...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity transcription factor binding histone acetyltransferase binding...

transcription coactivator activity transcription factor binding chromatin binding protein binding nuclear receptor binding nuclear receptor coactivator activity...

domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2. A possible...

(ZNF) MADS-box gene family NF-kB NOTCH2NL Nuclear receptor P300-CBP coactivator family Transcription factors SOX gene family Immunoglobulin superfamily...

Lee HM, Park OK, Jung SY, et al. (July 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular...

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene. This gene has been shown to be linked to weight gain...

Medina A, Katsaros D, Weber BL, Coukos G (Feb 2005). "Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian...

bifunctional protein pterin-4a-carbinolamine dehydratase and transcriptional coactivator (DCoH)". American Journal of Human Genetics. 62 (6): 1302–1311. doi:10...

transactivation function without affecting interactions with DNA or the CBP coactivator". Oncogene. 20 (26): 3376–86. doi:10.1038/sj.onc.1204439. PMID 11423988...

Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through...

expression data Gene ontology Molecular function DNA binding transcription coactivator activity metal ion binding nucleic acid binding DNA-binding transcription...

GTPase inhibitor activity protein binding cyclin binding transcription coactivator activity transcription corepressor activity Cellular component nucleoplasm...

of the electroencephalogram (EEG) p300 (or EP300), a transcriptional coactivator Nikon Coolpix P300, a mid-class compact digital camera, produced by Nikon...

chaperone binding FBXO family protein binding zinc ion binding transcription coactivator activity ubiquitin-protein transferase activity identical protein binding...

microcomedone formation. The retinoid-receptor complex competes for coactivator proteins of AP-1, a key transcription factor involved in inflammation...

Staal A; et al. (2003). "Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated...

sequence-specific DNA binding DNA binding protein N-terminus binding transcription coactivator activity N-acetyltransferase activity chromatin binding protein binding...

protein can function as a transcriptional coactivator in the Stat5 signaling pathway and also as a coactivator of NF-kappaB-mediated transcription, likely...

of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain...

ontology Molecular function signal transducer activity transcription coactivator activity protein binding Cellular component cytoplasm nucleus cytosol...

transcription of genes that induce cell proliferation. Transcriptional coactivators YAP, WWTR1 genes glioma, melanoma, lung cancer, breast cancers, and more...

J, Wu X, et al. (February 2014). "TBLR1 as an androgen receptor (AR) coactivator selectively activates AR target genes to inhibit prostate cancer growth"...

complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery. Retinoic...

bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation, motile function...

2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors...

of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12747–52. Bibcode:2002PNAS....

EXTL3: exostosin-like glycosyltransferase 3 EYA1: EYA transcriptional coactivator and phosphatase 1 FABP9: fatty acid binding protein 9, testis FAM167A:...

information available in the PDB for UniProt: P46937 (Human Transcriptional coactivator YAP1) at the PDBe-KB. Overview of all the structural information available...

Waters C, White A, Ray D (May 2003). "Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid...

LYL1, MAP3K7IP2, MAP3K8, MEN1, NFKB2, NFKBIE, NOTCH1, Nuclear receptor coactivator 1, RELA, RELB, STAT3, STAT6, and TSC22D3. GRCh38: Ensembl release 89:...

ribosomal subunit rRNA binding protein binding RNA binding transcription coactivator binding ubiquitin protein ligase binding ubiquitin ligase inhibitor activity...

metal ion binding peptidase activity hydrolase activity transcription coactivator activity cysteine-type endopeptidase activity histone binding ubiquitin...

binding co-receptor binding frizzled binding protein binding transcription coactivator activity receptor ligand activity Cellular component endocytic vesicle...

PMC 86120. PMID 10938122. Chang CJ, Chen YL, Lee SC (October 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid...

cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors. COP9...

nucleotide in the THRB gene is mutated, but also on the genotype of coactivators. A systematic investigation in mice demonstrated a strong association...

G, Obata T, et al. (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986...

activity serine-type peptidase activity hydrolase activity transcription coactivator activity mRNA binding promoter-specific chromatin binding structural...

Bronson R, Griffin JD, Wu L (March 2006). "The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required...

H3K4 mono-methylation (H3K4me1), H3K27 acetylation, the transcriptional coactivator Mediator, and RNA polymerase II on enhancers, resulting in severe defects...

largest banking insolvency Amplified in breast 1, or Nuclear receptor coactivator 3, a protein found in humans AAIB (disambiguation) All pages with titles...

interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator". European Journal of Biochemistry. 271 (18): 3741–51. doi:10.1111/j...

Lo E, Schapira M, Abagyan R, Samuels HH (Oct 1999). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Molecular...

ion binding sequence-specific DNA binding SMAD binding transcription coactivator activity DNA binding nucleic acid binding histone-lysine N-methyltransferase...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

MacDonald PN (September 2003). "Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated...

(2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem...

2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Molecular and Cellular Biology. 22 (21):...

binding androgen receptor binding protein kinase binding transcription coactivator activity transcription corepressor activity SUMO binding protein heterodimerization...

acid binding intermediate filament binding enzyme binding transcription coactivator activity GDP binding G-quadruplex DNA binding Cellular component cytoplasm...

factor, alpha subunit 60kDa". Vogel JL, Kristie TM (Feb 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription...

"Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. Bibcode:1996PNAS...

encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop...

MacDonald PN (2003). "Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

DNA-binding transcription factor activity DNA binding transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase...

CDK4 and CDK6, thyroid hormone receptor beta, and nuclear receptor coactivator 1, among others. Cyclin D and CDKs promote cell cycle progression by...

Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–4331....

ligase activity DNA-binding transcription factor activity transcription coactivator activity metal ion binding ubiquitin-protein transferase activity protein...

receptor-interacting protein (DRIP) complex which functions as a nuclear receptor coactivator. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent...

shown to interact with: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha and Retinoid X receptor alpha. A number of ligands for FXR are...

data Gene ontology Molecular function SH3 domain binding transcription coactivator activity zinc ion binding protein binding ubiquitin protein ligase binding...

scripting language KIX domain, protein interaction domain in the P300-CBP coactivator family Kix, the codename for the Google Docs edit surface and rendering...

interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". The Journal of Biological Chemistry. 272 (18): 12062–8. doi:10...

PMID 9434190. Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10...

Tsai MJ, O'Malley BW (Nov 1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science. 270 (5240): 1354–7...

impairs both DNA binding to androgen response elements and recruitment of coactivators. Enzalutamide (Xtandi) Medivation Approved High binding affinity to AR...

characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol...

C, Ma YQ, Bialkowska K, Byzova T, Plow EF (May 2011). "The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish"...

transcription factor RFX5. Hence CIITA is classified as a transcriptional coactivator. The CIITA protein contains an acidic transcriptional activation domain...

p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. 277 (33). United States: 30031–9. doi:10...

PMID 9373149. Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10...

adjacent thyroid hormone receptor ligand-binding domain's (TR-LBD), AF-2 coactivator-binding groove are necessary for the creation of the H0 structure of...

2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors...

-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. Bibcode:2002PNAS....

Gelmann EP (January 2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Molecular Endocrinology...

SE (2004). "Structural basis for HNF-4alpha activation by ligand and coactivator binding". J. Biol. Chem. 279 (22): 23311–6. doi:10.1074/jbc.M400864200...

(May 2004). "Structural basis for HNF-4alpha activation by ligand and coactivator binding". J. Biol. Chem. 279 (22): 23311–6. doi:10.1074/jbc.M400864200...

found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The...

liquiritigenin was due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes. Liquiritigenin did not stimulate uterine...

[citation needed] Nucleolin is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII)...

Upregulation = cell cycle arrest Focal adhesion kinase (FAK) & Steroid receptor coactivator (Src) Suppression= inhibition of vein endothelial cells VEGFR Inhibition=...

MED18 gene. Med18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase...

of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator". Proceedings of the National Academy of Sciences of the United States...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity transcription factor binding histone acetyltransferase binding...

(2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem...

interact with: CREB-binding protein, EP300, IRF4, NFKB1, Nuclear receptor coactivator 1, SND1, and Retinoblastoma protein. Interleukin 4 GRCh38: Ensembl release...

loop, govern the level of transcription of the target gene. Mediator (coactivator) (a complex usually consisting of about 26 proteins in an interacting...

SRCAP encodes a SNF2-related chromatin-remodeling ATPase that is a coactivator for CREB-binding protein (or CBP), which is the major cause of Rubinstein–Taybi...

(July 6, 2012). "Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus". Cell. 150 (1): 207–221. doi:10.1016/j...

PMID 9373149. Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12...

transcription factors bind to the promoter region, they also bind to coactivators, assembling into a large structure known as an enhanceosome. The composition...

calcium/calmodulin-dependent protein kinase IV, and the peroxisome proliferator γ coactivator 1 (PGC-1). The Ras/MAPK signaling pathway links the motor neurons and...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

homocysteine are known to positively regulate glyA. Homocysteine is a coactivator of glyA and must act in concert with MetR. On the other hand, PurR, a...

transcription activator activity, RNA polymerase II-specific transcription coactivator activity transcription factor binding protein binding protein heterodimerization...

nucleic acid binding RNA binding single-stranded DNA binding transcription coactivator activity endonuclease activity 3'-5' exonuclease activity Cellular component...

Identifiers Aliases EYA1, BOP, BOR, BOS1, OFC1, EYA transcriptional coactivator and phosphatase 1 External IDs OMIM: 601653; MGI: 109344; GeneCards:...

for interacting with the basal transcription complex including many coactivators of transcription such as TBP, TFIIB and CREB-CBP. RELA and p50 is the...

"Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197...

variable, in statistics Mediator (coactivator), a multiprotein complex that functions as a transcriptional coactivator Endogenous mediator, proteins that...

the zebrafish restores normal development. MED12 is also a critical coactivator for the gene SOX9, which is involved in the developmental regulation...

repression, or suppression – decrease the rate of gene transcription coactivator – a protein (or a small molecule) that works with transcription factors...

subsequently phosphorylates peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), the master regulator of mitochondrial biogenesis. Developing...

receptor 2 145,000 C3d, iC3b, C3dg, Epstein-Barr virus CD21 B, FDC B cell coactivator, primary Epstein-Barr virus receptor, CD23 receptor CR3 Macrophage-1...

Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator". Genes Dev. 20 (11): 1470–1484. doi:10.1101/gad.1416106. PMC 1475760...

Kieff E, Silvennoinen O (September 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". EMBO J. 21 (18):...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

differentiation. ERK3/MAPK6 interacts with and phosphorylated steroid receptor coactivator 3 (SRC-3) This coreceptor is an oncogenic protein which when overexpressed...

(CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators". J. Biol. Chem. 277 (37): 34626–33. doi:10.1074/jbc.M205239200. PMID 12114525...

flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300". Molecular Cell. 7 (6): 1221–1231. doi:10.1016/s1097-2765(01)00272-6...

monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1...

Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1". The Journal of Biological Chemistry. 290 (36): 21876–89. doi:10.1074/jbc...

binding bubble DNA binding phosphotyrosine residue binding transcription coactivator activity neuropilin binding SH2 domain binding ephrin receptor binding...

Gelmann EP (January 2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol...

CK, Rosenfeld MG (Jul 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor...

differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

sequence-specific DNA binding nucleosomal DNA binding transcription coactivator activity protein binding Cellular component SWI/SNF complex nucleus nucleoplasm...

et al. (December 1998). "The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen". Cell...

known as activators and repressors, and, in some cases, associated coactivators or corepressors, which modulate formation and function of the transcription...

Molecular function DNA-binding transcription factor activity transcription coactivator activity protein binding identical protein binding DNA binding Cellular...

Friedrichs N, Vorreuther R, et al. (December 2006). "Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain...

1038/nrg2322. PMID 18319743. S2CID 690431. Shoag J; et al. (Jan 2013). "PGC-1 coactivators regulate MITF and the tanning response". Mol Cell. 49 (1): 145–157. doi:10...

polymerase and other transcription machinery in the same region. See also coactivator; contrast repressor. active site The region of an enzyme to which one...

liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator". J. Biol. Chem. 276 (16): 13395–401. doi:10.1074/jbc.M011176200. PMID 11278855...

Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor"...

steroid hormone-mediated gene activation as a steroid hormone receptor coactivator. Similar to BRCA1, GT198 is a breast and ovarian cancer susceptibility...

that bind to and activate receptor proteins are termed cofactors or coactivators, whereas molecules that inhibit receptor proteins are termed corepressors...

Molecular function DNA-binding transcription factor activity transcription coactivator activity protein binding DNA binding DNA-binding transcription factor...

increase levels of peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC1-α), suggesting that lactate stimulates mitochondrial biogenesis...

expression data Gene ontology Molecular function DNA binding transcription coactivator activity R-SMAD binding transcription corepressor activity p53 binding...

gamma (PPARγ), PRDM16, peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and Early B-Cell Factor-2 (EBF2). The list of molecules...

2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32). United States:...

(ATXN7) Two Hybrid, Pull-Down Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and...

association with the gene Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Beta (PPARGC1B) has been reported. This gene is a transcription factor...

SDS-PAGE gels, as it is described for instance for a transcriptional coactivator by Kovacs et al. Strong phosphorylation-related conformational changes...

nuclear envelopes of the daughter nuclei. RAN is an androgen receptor (AR) coactivator (ARA24) that binds differentially with different lengths of polyglutamine...

Tong Ihn; Hnisz, Denes; Malik, Sohail; Vasile, Eliza (2018-07-27). "Coactivator condensation at super-enhancers links phase separation and gene control"...

transcription regulator protein 1 (WWTR1), also known as Transcriptional coactivator with PDZ-binding motif (TAZ), is a protein that in humans is encoded...

a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions". J. Biol...

(February 1999). "The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily". Molecular and Cellular...

Andersson U, Scarpulla RC (May 2001). "PGC-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription...

BioGPS n/a Gene ontology Molecular function protein binding transcription coactivator binding Cellular component nucleus Biological process regulation of transcription...

Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (October 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity leucine zipper domain binding protein binding Cellular component...

reference expression data Gene ontology Molecular function transcription coactivator activity protein binding identical protein binding Cellular component...

"Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities". The Journal of Biological Chemistry. 286 (15): 12971–12982...

loop, govern the level of transcription of the target gene. Mediator (coactivator) (a complex usually consisting of about 26 proteins in an interacting...

2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors...

DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator". Molecular Cell. 18 (4): 471–81. doi:10.1016/j.molcel.2005.04.005. PMID 15893730...

reference expression data Gene ontology Molecular function transcription coactivator activity hyaluronoglucuronidase activity catalytic activity virus receptor...

function chromatin binding DNA binding protein binding transcription coactivator activity acetyltransferase activator activity Cellular component nucleus...

Roeder RG (1998). "Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional...

"Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197...

2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors...

Molecular function transferase activity nucleotide binding transcription coactivator activity ubiquitin-protein transferase activity protein binding ubiquitin-protein...

repression, or suppression – decrease the rate of gene transcription coactivator – a protein (or a small molecule) that works with transcription factors...

cell-surface vitamin K–dependent protein that binds to the transcriptional coactivator Yes-associated protein". Proceedings of the National Academy of Sciences...

PPFIA4 has been shown to interact with: ERC2, GIT1, and Nuclear receptor coactivator 2. GRCh38: Ensembl release 89: ENSG00000143847 – Ensembl, May 2017 "Human...

transcriptional target of peroxisome proliferator-activated receptor gamma coactivator 1-alpha 4 and regulates overload-induced muscle hypertrophy through Gα12/13...

activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". The Journal of Biological Chemistry. 275 (17): 12515–20. doi:10...

complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes...

signaling axis functioning upstream of SRF. On the other hand, FHL2 is the coactivator of AR and is able to modulate AR signaling by altering the effect of...

2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors...

characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". The Journal...

Schapira M, Abagyan R, Samuels HH (February 2000). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Mol Cell...

2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal...

this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding...

Medicine. Blencowe BJ, Issner R, Nickerson JA, Sharp PA (May 1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12...

WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells". Mol. Cancer Res. 13 (5): 902–12. doi:10...

peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α). (PGC1α) is a transcriptional coactivator that drives the gene expression programming...

transferase activity protein kinase activity nucleotide binding transcription coactivator activity kinase activity protein serine/threonine kinase activity NF-kappaB-inducing...

ligands to RAR results in dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target...

accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal. 2011;4(174):ra33. 27.       Pavel M, Park SJ, Frake...

Capone JP, Rachubinski RA (Nov 1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". Journal of Biological Chemistry...

early S-phase, the cyclin E-Cdk2 complex phosphorylates NPAT, a nuclear coactivator of histone transcription. NPAT is activated by phosphorylation and recruits...

Capone JP, Rachubinski RA (November 1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200...

otherwise bind to TBP and interfere with PIC formation. TFIIA also acts as a coactivator for some transcriptional activators, assisting with their ability to...

transcriptional coregulator, is essential for cell function because as a coactivator at a significant number of promoters, it activates the transcription...

of ligand. ERRα does, however, interact with the metabolic-inducible coactivator PGC1-α in its AF2 region which is sometimes referred to as the "protein...

reference expression data Gene ontology Molecular function transcription coactivator activity metal ion binding cadherin binding involved in cell-cell adhesion...

S2CID 45515641. Klugbauer S, Rabes HM (July 1999). "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase...

9 25 Medroxyprogesterone 241 47 32 Medroxyprogesterone acetate 1.2 0.6 0.15 Footnotes: a = Coactivator recruitment. b = Reporter cell line. Sources:...

ontology Molecular function sequence-specific DNA binding transcription coactivator activity DNA binding protein dimerization activity DNA-binding transcription...

contained in coactivators. Conversely, antagonists destabilize the agonist conformation of H12 blocking the binding of the FXXLF coactivator motif while...

cis-regulatory region sequence-specific DNA binding DNA binding transcription coactivator activity protein binding nucleosomal DNA binding DNA-binding transcription...

dysplasia–cleft syndrome 3/Limb–mammary syndrome/OFC8 Transcription coregulators Coactivator: CREBBP Rubinstein–Taybi syndrome Corepressor: HR (Atrichia with papular...

2002). "Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator...

ribosomal small subunit binding unfolded protein binding transcription coactivator activity protein kinase inhibitor activity histone binding Tat protein...

component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free...

down-regulate the expression of HER2. However, when the ratio of the coactivator AIB-3 exceeds that of the corepressor PAX2, the expression of HER2 is...

Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391...

acids also suppresses liver expression of apolipoprotein C3 and PPARg coactivator-1b, thus increasing VLDL-C turnover and reducing its production. Nicotinic...

domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response...

machinery. On the basis of this function, p300 is called a transcriptional coactivator. The p300 interaction with transcription factors is managed by one or...

acid binding intermediate filament binding enzyme binding transcription coactivator activity GDP binding G-quadruplex DNA binding Cellular component cytoplasm...

eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family. Without Wnt...

Morimoto T, Kakita T, Yanazume T, Sasayama S (2000). "A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain...

both as an activator to bind DNA in a sequence specific manner and a coactivator to stimulate synergistic activation by Dorsal and Twist. Zhao K, Hart...

Coonrod SA, Kraus WL, Jelinek MA, Stallcup MR (March 2005). "Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination"...

by Taiman, a Drosophila Protein Related to AIB1, a Steroid Receptor Coactivator Amplified in Breast Cancer". Cell. 103 (7): 1047–1058. doi:10...

functional interactions between the transcription factor PU.1 and the coactivator CBP". Oncogene. 18 (7): 1495–1501. doi:10.1038/sj.onc.1202427. PMID 10050886...

Malik S, Gu W, Wu W, et al. (2000). "The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs"...

(2004). "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions...

transcription factor activity, RNA polymerase II-specific transcription coactivator binding transcription cis-regulatory region binding Cellular component...

cis-regulatory region sequence-specific DNA binding DNA binding transcription coactivator activity metal ion binding protein binding DNA-binding transcription...

activity protein binding ATP binding helicase activity transcription coactivator activity hydrolase activity nucleic acid binding ATP-dependent activity...

reported (1954). When doped with, for example, Cu+ ("activator") and Al3+ ("coactivator"), CdS luminesces under electron beam excitation (cathodoluminescence)...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity protein binding Cellular component cytoplasm nucleus mitochondrion...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

(IXL), which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role...

corepressor for nuclear receptors such as glucocorticoid receptors and a coactivator for estrogen receptors. Proline-, glutamic acid-, and leucine-rich protein...

factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Molecular Endocrinology. 14 (6): 915–925. doi:10.1210/mend.14...

2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell. 20 (5): 759–70. doi:10...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity kinase binding protein binding molecular adaptor activity Cellular...

sequence-specific DNA binding transcription factor binding nuclear receptor coactivator activity signaling receptor activity Cellular component cytoplasm nucleoplasm...

Shindo H, Yamashita S, Tsukazaki T (Aug 2003). "P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through...

"Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins". The EMBO Journal. 22 (10). Wiley:...

ontology Molecular function molecular adaptor activity transcription coactivator activity chromatin binding protein binding signaling receptor binding...

(2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J....

protein kinase  • PGC‐1α: peroxisome proliferator-activated receptor gamma coactivator-1α  • S6K1: p70S6 kinase  • 4EBP1: eukaryotic translation initiation...

2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors...

"Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins". The EMBO Journal. 22 (10): 2453–62...

Anastassiadis T, Peterson JR (November 2010). "Phosphoinositides are essential coactivators for p21-activated kinase 1". Molecular Cell. 40 (3): 493–500. doi:10...

Zhou, MM (2005). "Selective Small Molecules Blocking HIV-1 Tat and Coactivator PCAF Association". Journal of the American Chemical Society. 127 (8):...

interactions include the BAF (SWI/SNF) complex. RAC3 and p300. MN1 can act as a coactivator of several transcription factors, including RAR/RXR and the vitamin D...

that they do not have a helix in the C-terminal that is necessary for coactivator recruitment and activation by nuclear receptors via their LBD. Instead...

itself appears to act as a coactivator of ER-α.[better source needed] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently...

A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9...

cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells". Cancer Res. 66 (17):...

Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM"...

ontology Molecular function sequence-specific DNA binding transcription coactivator activity zinc ion binding metal ion binding steroid hormone receptor...

2008). "SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis". Genes Dev. 22 (2):...

conformations. The first is an agonist conformation which favors the binding of coactivator proteins which in turn favors upregulation of gene transcription. The...

PMC 20057. PMID 9122164. Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12...

Ohta H, Nozawa S, Kato S (July 2003). "p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor". Biochemical...

upregulate Cdx2 in the TE and its transcriptional activity depends on the coactivator Yap. Yap's nuclear localization in outside cells allows it to contribute...

brain. PKM2 is enzyme pyruvate kinase M2 (PKM2) and a transcriptional coactivator of STAT1 responsible for the induction of the protein PD-L1 expression...

2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors...

DNA-binding transcription factor activity DNA binding transcription coactivator activity protein binding metal ion binding sequence-specific DNA binding...

corepressor activity DNA-binding transcription factor activity transcription coactivator activity metal ion binding protein binding DNA-binding transcription...

PMID 8889548. Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci....

intracellular metabolism, functional selectivity (differential recruitment of coactivators), and non-genomic mechanisms (i.e., signaling through non-AR membrane...

transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein". The Journal of Biological Chemistry. 275 (22):...

prolonged fasting via PPAR-alpha and in turn induces the transcriptional coactivator PGC-1α and stimulates hepatic gluconeogenesis, fatty acid oxidation,...

factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. doi:10.1210/mend.14.6.0471....

remain unknown. However, recruitment of both coactivators and corepressors instead of only coactivators and resultant differing receptor conformations...

Shima D, et al. (1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391...

telomerase RNA reverse transcriptase activity protein binding transcription coactivator binding telomerase RNA binding telomerase activity protein homodimerization...

the nucleus with the help of Rac1. At this point, β-catenin becomes a coactivator for TCF and LEF to activate Wnt genes by displacing Groucho and HDAC...

expression of exercise-regulated muscle genes. PGC-1alpha, a transcriptional coactivator, is a key transcription factor involved in mediating the UPR in a tissue-specific...

Both of these related proteins, prototypical members of the p300-CBP coactivator family, have a bromodomain and a histone acetyltransferase domain and...

SJ, Natarajan K, Yoon S, Hinnebusch AG (Apr 2003). "A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo". Molecular and...

of cellular factors, collectively termed coregulators and including coactivators and corepressors. The study of nuclear receptors owed a debt to decades...

S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector"...

nucleoside binding transmembrane transporter binding nuclear receptor coactivator activity integrin binding retinoic acid receptor binding chromatin DNA...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

Y14, SRm160, Aly/REF and Magoh, among others. RNPS1 can function as a coactivator of splicing, but along with Y14, it also takes part in the process of...

F. Q., & Johnson, T. L. (2009). Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assembly. PLoS...

Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J...

DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator". Mol. Cell. 18 (4): 471–81. doi:10.1016/j.molcel.2005.04.005. PMID 15893730...

sequence-specific DNA binding DNA binding protein N-terminus binding transcription coactivator activity chromatin binding protein binding nucleosomal DNA binding DNA-binding...

Pärt (2012-08-15). "Autoimmune regulator is acetylated by transcription coactivator CBP/p300". Experimental Cell Research. 318 (14): 1767–1778. doi:10.1016/j...

protein ataxia-telangiectasia (NPAT), also known as nuclear protein coactivator of histone transcription, is a transcription factor which activates histone...

fibroblast growth factor receptor binding protein binding nuclear receptor coactivator activity chemoattractant activity growth factor activity protein tyrosine...

Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM"...

Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol...

ion binding histone-lysine N-methyltransferase activity transcription coactivator activity histone methyltransferase activity (H3-K36 specific) Cellular...

II; Roeder, RG; Sharp, PA; Chakraborty, AK; Young, RA (27 July 2018). "Coactivator condensation at super-enhancers links phase separation and gene control"...

p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5): 1137–49. doi:10.1016/S1097-2765(03)00391-5...

nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology. 15 (9):...

factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors...

DVL allows for β-catenin buildup in the nucleus, where it acts as a coactivator for TCF (T cell factor) to activate Wnt responsive genes. Conversely...

TEAD2 interacts with all members of the SRC family of steroid receptor coactivators. It has been shown in HeLa cells that TEAD2 and SRC induce gene expression...

retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator". The Journal of Biological Chemistry. 277 (47): 45611–8. doi:10.1074/jbc...

1074/jbc.M509266200. PMID 16267050. Miao F, Li S, Chavez V, et al. (2006). "Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated...

and HDAC2 and suggest a novel function for HDAC1 as a transcriptional coactivator. HDAC1 expression was found to be increased in the prefrontal cortex...

activity histone methyltransferase activity (H3-K36 specific) transcription coactivator activity protein-lysine N-methyltransferase activity Cellular component...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity beta-catenin binding transcription coregulator activity Cellular...

Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator". Genes & Development. 20 (11): 1470–84. doi:10.1101/gad.1416106. PMC 1475760...

(December 1999). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Molecular Endocrinology. 13 (12):...

T, Nabeshima Y, et al. (April 1998). "UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells"...

between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Molecular and Cellular Biology. 20 (23): 8933–43. doi:10.1128/MCB.20...

hand, it is required for Wnt signaling: possibly to recruit various coactivators, such as 14-3-3zeta. Yet its exact partners among the general transcription...

deregulation of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha / mitochondrial transcription factor A (PGC-1α/TFAM) signaling...

GAPDH can itself activate transcription. The OCA-S transcriptional coactivator complex contains GAPDH and lactate dehydrogenase, two proteins previously...

loop, govern the level of transcription of the target gene. Mediator (coactivator) (a complex usually consisting of about 26 proteins in an interacting...

protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct...

activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865...

transcription regulatory region sequence-specific DNA binding transcription coactivator activity protein binding DNA-binding transcription repressor activity...

reference expression data Gene ontology Molecular function transcription coactivator activity histone binding p53 binding transcription factor binding protein...

of genes which it regulates. A variety of additional proteins called coactivators complex with the activated VDR/RXR heterodimers either to form a bridge...

reference expression data Gene ontology Molecular function transcription coactivator activity protein heterodimerization activity transmembrane signaling...

binding histone H3-methyl-lysine-9 demethylase activity transcription coactivator activity dioxygenase activity metal ion binding methylated histone binding...

Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator". Genes & Development. 20 (11): 1470–1484. doi:10.1101/gad.1416106. PMC 1475760...

Heinrich R (2004). "Biological control through regulated transcriptional coactivators". Cell. 119 (2): 157–67. doi:10.1016/j.cell.2004.09.037. PMID 15479634...

transcription initiation. Activators can recruit molecules known as coactivators. These coactivator molecules can then perform functions necessary for beginning...

synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators". Nature. 415 (6871): 549–553. doi:10.1038/415549a. PMID 11823864. S2CID 4423920...

R (August 2021). "Role of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous...

Constitutive coactivator of PPAR-gamma-like protein 1 is a protein that in humans is encoded by the FAM120A gene. GRCh38: Ensembl release 89: ENSG00000048828...

target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. Bibcode:2005PNAS..102...

Rosenfeld, Michael G. (2006). "Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells". Proceedings...

and anterior truncations.” This data also discloses that Ssdp1 is a coactivator that enhances transcriptional activity with Lim-1 as a complex. These...

correlated with Morbid obesity. Also, C1orf94 increased after related coactivator depletion. The function of C1orf94 is not yet fully understood and there...

(June 2021). "Hydrophobic Tagging-Mediated Degradation of Transcription Coactivator SRC-1". International Journal of Molecular Sciences. 22 (12): 6407. doi:10...

Abdeladim Moumen, and the paper 'hnRNP K: An HDM2 Target and Transcriptional Coactivator of p53 in Response to DNA Damage' was retracted from Cell. Jackson has...

residue. When activated, CREB protein recruits other transcriptional coactivators to bind to CRE promoter 5’ upstream region. Hydrophobic leucine amino...

Lichtensteiger, Walter (1 May 2005). "Estrogen Target Gene Regulation and Coactivator Expression in Rat Uterus after Developmental Exposure to the Ultraviolet...

function DNA binding transcription corepressor activity transcription coactivator activity zinc ion binding metal ion binding protein binding four-way...

stimulates the expression of peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α). Furthermore, Trx1 reduces two cysteine residues in histone...

(February 2000). "CBP/p300 interact with and function as transcriptional coactivators of BRCA1". Proceedings of the National Academy of Sciences of the United...

has been shown to be transcriptionally regulated by a transcriptional coactivator PSIP1/p52 H3K4me1 H3K4me3 Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman...

Proline-rich nuclear receptor coactivator 2 is a protein that in humans is encoded by the PNRC2 gene. GRCh38: Ensembl release 89: ENSG00000189266 – Ensembl...

Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the...

Xu J, O'Malley BW (March 2007). "An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response"...

element within the insulin promoter. Upon translocation it interacts with coactivators HAT p300 and SETD7. PDX1 affects the histone modifications through acetylation...

11212. PMID 9556611. Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12...

expression data Gene ontology Molecular function DNA binding transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase...

gene was frequently confused with a protein called TAZ (transcriptional coactivator with PDZ-binding motif, a 50 kDa protein). which is a part of the Hippo...

reference expression data Gene ontology Molecular function transcription coactivator activity protein binding histone acetyltransferase binding Cellular component...

conformational change that causes co-repressors to dissociate from the receptors. Coactivators can then bind to the receptor complex, which may help to loosen the chromatin...

Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through...

Zhou S, Näär AM (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional...

expression data BioGPS n/a Gene ontology Molecular function transcription coactivator activity histone binding lysine-acetylated histone binding Cellular component...

2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors"....

and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1...

2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal...

Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through...

the ability to more effectively recruit coactivators (through increased coactivator expression, AR or coactivator phosphorylation, or other modifications)...

Janknecht R (Feb 2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene....

integrin binding actin filament binding protein binding nuclear receptor coactivator activity double-stranded RNA binding actin binding structural constituent...

PMID 9447963. Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10...

(2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem...

corepressors and in the presence of coactivators, transcription factors upregulate gene expression. Coactivators and corepressors compete for the same...

receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. A crystal...

Hasan S, Hassa PO, Imhof R, Hottiger MO (March 2001). "Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis". Nature...

B, Riedel D, Müller SA, et al. (December 2005). "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model...

(February 2002). "Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus". Mol. Biol. Cell. 13 (2): 670–82...

Cervellera MN, Sala A (April 2000). "Poly(ADP-ribose) polymerase is a B-MYB coactivator". The Journal of Biological Chemistry. 275 (14): 10692–10696. doi:10...

calcium-dependent protein binding ubiquitin binding protein binding nuclear receptor coactivator activity virion binding ubiquitin protein ligase binding protein-containing...

cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein". Proc. Natl. Acad. Sci. U.S.A. 104 (21): 8767–72...

silencing: Competition with coactivators – The LXXLL motifs of NRIP1 compete with those of coactivators such as steroid receptor coactivator 1 (SRC‑1/NCOA1) for...

cis-regulatory region sequence-specific DNA binding DNA binding transcription coactivator activity DNA-binding transcription repressor activity, RNA polymerase...

U, Adler G, et al. (November 2001). "p300 acts as a transcriptional coactivator for mammalian Notch-1". Molecular and Cellular Biology. 21 (22): 7761–7774...

glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent...

ontology Molecular function actin binding protein binding transcription coactivator activity Arp2/3 complex binding Cellular component cytoskeleton cell...

at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1". Current Biology. 11 (12): 996–1000. Bibcode:2001CBio...11..996S...

1993). "The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers". Genes & Development...

binding chromatin binding transcription coregulator activity transcription coactivator activity DNA-binding transcription factor activity, RNA polymerase II-specific...

Collingwood TN, Urnov FD, Wolffe AP (December 1999). "Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription"...

corepressor activity DNA-binding transcription factor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase...

Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proceedings of the National...

Robert; Folkers, Gert E (2006). "Gradual phosphorylation regulates PC4 coactivator function". FEBS Journal. 273 (7): 1430–44. doi:10.1111/j.1742-4658.2006...

274.50.35475. PMID 10585419. Vogel JL, Kristie TM (2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription...

Masuhiro Y, Mori M, Yanagisawa J, Kato S (Mar 2000). "p300/CBP acts as a coactivator of the cone-rod homeobox transcription factor". Biochemical and Biophysical...

Goldring MB, Labelle Y (Jan 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein...

ubiquitin-protein ligase TRIM68; Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity;...

Hsiao WC, Stierle M, Kao CF, Tora L, Devys D (September 2014). "The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA...

proliferation and survival. CREBBP: This gene's product is a transcriptional coactivator; it activates numerous transcription factors, some of which control cell...

PMID 12565863. Ge H, Si Y, Wolffe AP (Dec 1998). "A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2"...

1093/nar/gkw1140. PMC 5389617. PMID 27899669. "ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development"...

displacing the corepressor from the complex. This leads to recruitment of coactivator proteins and RNA polymerase, activating transcription of the gene. Although...

(May 2003). "Actin dynamics control SRF activity by regulation of its coactivator MAL". Cell. 113 (3): 329–342. CiteSeerX 10.1.1.327.7451. doi:10...

2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal...

myogenic and neural differentiation. MAML3 encodes a transcriptional coactivator involved in Notch signaling. The PAX3-MAML3 fusion juxtaposes the N-terminal...

leukemia protein (PML)/peroxisome proliferation-activated receptor-gamma coactivator 1α (PGC-1α)/peroxisome proliferator-activating receptor type δ (PPARδ)...

methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc Natl Acad Sci U S A. 98 (18): 10380–5. Bibcode:2001PNAS...

transferase activity protein kinase activity 7SK snRNA binding transcription coactivator binding snRNA binding ATP binding RNA polymerase II core promoter sequence-specific...

"topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage". Oncogene. 24 (21):...

Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator". Genes & Development. 20 (11): 1470–1484. doi:10.1101/gad.1416106. PMC 1475760...

Stallcup MR (Aug 1999). "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3". The Journal of Biological...

activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". The Journal of Biological Chemistry. 275 (17): 12515–20. doi:10...

Jung N, Hong SS, Lee HS, Bae I (2000). "Gadd45 family proteins are coactivators of nuclear hormone receptors". Biochem. Biophys. Res. Commun. 272 (1):...

Yu S, Guo D, Rao MS, Reddy JK (May 2006). "PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex". Biochemical...

interact with PRKRIR. STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis. GRCh38: Ensembl release...

after conditional deletion 15778706 GADD45GIP1 Crif1 Essential Elf3 coactivator in differentiation of absorptive enterocytes 19801644 GATA6 Regulates...

PMID 9305922. Li XY, Green MR (October 1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes & Development...

activity transcription factor binding chromatin binding transcription coactivator activity cis-regulatory region sequence-specific DNA binding DNA-binding...

ligand exposes a site on the AF2 domain for coactivators to attach to the ER. By recruiting coactivators and transcription factors, transcription of downstream...

addition prevents binding of AR to deoxyribonucleic acid (DNA) and AR to coactivator proteins. As such, it has been described as an AR signaling inhibitor...

mass spectrometry: cyclopeptidic inhibitors of the nuclear receptor coactivator 1-STAT6". J. Am. Soc. Mass Spectrom. 20 (2): 303–11. Bibcode:2009JASMS...

(2005). "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes". Mol. Endocrinol. 19 (10): 2451–65. doi:10.1210/me.2004-0476...

co-activators increase the rate of transcription of target genes. The coactivators are able to do this by making genes on DNA more accessible to STATs and...

(PPARs), estrogen-related receptors (ERRs), and their transcriptional coactivators. Kelly and his team found that the failing heart begins to rely on ketone...

Cross NC (1998). "A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia". Blood. 91 (9): 3127–33. doi:10.1182/blood...

like peroxisome proliferator-activated receptor gamma (PPAR-γ) and coactivator 1 alpha (PGC-1α). The hypermethylation of these genes decreases the expression...

binding DNA binding transcription corepressor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase...

DNA binding DNA-binding transcription factor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase...

in the Nucleus. The N-terminal end allows for the binding of various coactivators, corepressors, and modifiers. All family members share the zinc finger...

complex on the TRPV6 gene promoter, 4) recruitment of steroid receptor coactivator 1 and RNA polymerase II on the promoter, and 5) transcriptional activation...

other proteins, as activator of adipose triglyceride lipase and its coactivator comparative gene identification-58, to regulate lipolysis in skeletal...