COG4

COG4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOG4, CDG2J, COD1, component of oligomeric golgi complex 4, SWILS
External IDsOMIM: 606976; MGI: 2142808; HomoloGene: 7155; GeneCards: COG4; OMA:COG4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

25839

102339

Ensembl

ENSG00000103051

ENSMUSG00000031753

UniProt

Q9H9E3

Q8R1U1

RefSeq (mRNA)

NM_001195139
NM_015386
NM_001365426
NM_145818

NM_133973
NM_001310607

RefSeq (protein)

NP_001182068
NP_056201
NP_001352355

NP_001297536
NP_598734

Location (UCSC)Chr 16: 70.48 – 70.52 MbChr 8: 111.57 – 111.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the COG4 gene.[5][6]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002).[supplied by OMIM][6]

Interactions

COG4 has been shown to interact with COG7,[7] COG2,[7] COG1[7] and COG5.[7]

Clinical

Mutations in this gene have been associated with Saul-Wilson syndrome.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103051 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031753 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  6. ^ a b "Entrez Gene: COG4 component of oligomeric golgi complex 4".
  7. ^ a b c d Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23). United States: 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
  8. ^ Ferreira C (2020) Saul-Wilson syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. SourceGeneReviews. Seattle (WA): University of Washington, Seattle

Further reading


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