COG1

COG1
Identifiers
AliasesCOG1, CDG2G, LDLB, component of oligomeric golgi complex 1
External IDsOMIM: 606973; MGI: 1333873; HomoloGene: 8411; GeneCards: COG1; OMA:COG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9382

16834

Ensembl

ENSG00000166685

ENSMUSG00000018661

UniProt

Q8WTW3

Q9Z160

RefSeq (mRNA)

NM_018714

NM_013581

RefSeq (protein)

NP_061184

NP_038609

Location (UCSC)Chr 17: 73.19 – 73.21 MbChr 11: 113.54 – 113.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.[5][6]

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.[6]

Interactions

COG1 has been shown to interact with COG4[7] and COG3.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166685 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018661 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex". Proc Natl Acad Sci U S A. 96 (3): 915–20. Bibcode:1999PNAS...96..915C. doi:10.1073/pnas.96.3.915. PMC 15325. PMID 9927668.
  6. ^ a b "Entrez Gene: COG1 component of oligomeric golgi complex 1".
  7. ^ Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23). United States: 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
  8. ^ Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24). United States: 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.

Further reading


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