Sefonisid

Sefonisid
Data klinis
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa601206
Kode ATC
Pengenal
  • Asam (6R,7R)-7-[(2R)-2-hidroksi-2-fenilasetil)amino]-8-okso-
    3-{[1-(sulfometil)tetrazol-5-il]sulfanilmetil}-
    5-tia-1-azabisiklo[4.2.0]okt-2-ena-2-karboksilat
Nomor CAS
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Data sifat kimia dan fisik
RumusC18H18N6O8S3
Massa molar542,56 g·mol−1
Model 3D (JSmol)
  • O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)[C@H](O)c3ccccc3)CSc4nnnn4CS(=O)(=O)O)C(=O)O
  • InChI=1S/C18H18N6O8S3/c25-13(9-4-2-1-3-5-9)14(26)19-11-15(27)24-12(17(28)29)10(6-33-16(11)24)7-34-18-20-21-22-23(18)8-35(30,31)32/h1-5,11,13,16,25H,6-8H2,(H,19,26)(H,28,29)(H,30,31,32)/t11-,13-,16-/m1/s1 checkY
  • Key:DYAIAHUQIPBDIP-AXAPSJFSSA-N checkY
  (verify)

Sefonisid atau sefonisida adalah salah satu antibiotik sefalosporin.[1] Antibiotik ini memiliki massa jenis sebesar 1,92g/cm3.

Sintesis

Antibiotik sefalosporin semi-sintetik suntik yang terkait dengan sefamandol, q.v.

Sintesis sefonisid:[2][3][4]

Sefonisid disintesis secara mudah melalui perpindahan nukleofilik gugus 3-asetoksi dari 1 dengan tetrazol tiol 2 yang tersubstitusi dengan tepat. Rantai samping amida asam mandelat C-7 mengingatkan pada sefamandol.

Referensi

  1. ^ Saltiel E, Brogden RN (September 1986). "Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use". Drugs. 32 (3): 222–59. doi:10.2165/00003495-198632030-00002. PMID 3530703. S2CID 243051006.
  2. ^ DE 2611270, Berges, David Alan, "Cephalosporin-Derivate [Cephalosporin derivatives]", diterbitkan tanggal 1976-09-30, diberikan kepada SmithKline Corp. 
  3. ^ D. A. Berges, U.S. Patent 4.048.311 (1977 to Smith Kline).
  4. ^ U.S. Patent 4.093.723, U.S. Patent 4.159.373 (1978, 1979 both to Smith Kline).
Ikon rintisan

Artikel bertopik antibakteri sistemik ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.