MELK

MELK
Struktur yang tersedia
PDBPencarian ortolog: PDBe RCSB
Pengidentifikasi
AliasMELK, HPK38, maternal embryonic leucine zipper kinase
ID EksternalOMIM: 607025; MGI: 106924; HomoloGene: 32111; GeneCards: MELK; OMA:MELK - orthologs
Nomor EC2.7.10.2
Ortologi
SpesiesManusiaTikus
Entrez

9833

17279

Ensembl

ENSG00000165304

ENSMUSG00000035683

UniProt

Q14680

Q61846

RefSeq (mRNA)

NM_010790

RefSeq (protein)

NP_034920

Location (UCSC)Chr 9: 36.57 – 36.68 MbChr 4: 44.3 – 44.36 Mb
PubMed search[3][4]
Wikidata
Lihat/Sunting ManusiaLihat/Sunting Tikus

Maternal embryonic leucine zipper kinase (MELK) adalah enzim yang pada manusia disandi oleh gen MELK.[5][6][7] MELK adalah serin/treonin kinase milik keluarga protein AMPK/snf1 kinase. MELK pertama kali diidentifikasi hadir sebagai mRNA maternal pada embrio tikus.[8] MELK telah terbukti terlibat dalam perkembangan melalui siklus sel, mungkin terkait dengan interaksinya dengan CDC25B.[9]

Ekspresi MELK meningkat pada sejumlah kanker dan merupakan target penelitian aktif untuk penghambatan farmakologis.[10]

Interaksi

MELK telah terbukti berinteraksi dengan CDC25B.[11]

Referensi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165304 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035683 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. February 1996. doi:10.1093/dnares/3.1.17. PMID 8724849.
  6. ^ "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Molecular Reproduction and Development. 47 (2): 148–56. June 1997. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
  7. ^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase".
  8. ^ "Expression of Melk, a new protein kinase, during early mouse development". Developmental Dynamics. 215 (4): 344–51. August 1999. doi:10.1002/(SICI)1097-0177(199908)215:43.0.CO;2-H. PMID 10417823.
  9. ^ "Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation". The Journal of Cell Biology. 170 (3): 413–27. August 2005. doi:10.1083/jcb.200412115. PMC 2171475. PMID 16061694.
  10. ^ "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers". Cancer Research. 65 (21): 9751–61. November 2005. doi:10.1158/0008-5472.CAN-04-4531. PMID 16266996.
  11. ^ "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. October 2002. doi:10.1038/sj.onc.1205870. PMID 12400006.
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