User:Ian Kates

My name is Ian Kates and I am an undergraduate student at Boston College. The purpose of my account and any activity that I may partake in on Wikipedia is to further the knowledge and information of neuroscience on Wikipedia.

Introduction to Neuroscience

A Class Project

I am currently taking a course called BI481 Introduction to Neuroscience. As a part of the course, we are have been tasked with helping the Society for Neuroscience expand the field of neuroscience in Wikipedia. Any changes that me or my group makes in Wikipedia will be due to our class project.

Links to the project proposal and the VLDL receptor page can be found below.

VLDL Receptor Project Proposal

VLDL receptor

Atherosclerosis

A pathological hallmark of atherosclerotic cardiovascular disease is the excessive accumulation of cholesterol by macrophages, leading to their transformation into foam cells. Accululation of cholesterol is caused by dysregulation of of the balance of cholesterol infulx and efflux. Foam cell accumulation initiates early atherosclerotic lesions in the arteries. Macrophages absorb cholesterol through many pathways and receptors. In addition, macrophages also express scavenger receptors, which internalize oxidatively modified lipoproteins. VLDL receptor has been identified as a receptor expressed by macrophages.[1]

Experiments showed that diet-induced atherosclerosis was facilitated by the LDL receptor. It is also a major pathway for the uptake of VLDL by the macrophage. In addition, the experiments showed that the VLDL receptors did not respond to cholesterol loading due to diet. To test the role of VLDL receptors, VLDL receptor expression was reconsitituted into mice with a VLDL receptor knockout. Reconstitution of VLDL receptor expression greatly increased atherosclerotic lesion development. The result of these experiments have implicated macrophage VLDLR is a pro-atherogenic factor..[2]

References

  1. ^ "Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development", FEBS Letters, 2006
  2. ^ "Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development", FEBS Letters, 2006

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.