DOSEN PROFIL LENGKAP

uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial carrier protein found in brown adipose tissue (BAT)....

related to thermogenesis. Although UCP2 and UCP3 are closely related to UCP1, UCP2 and UCP3 do not affect thermoregulatory abilities of vertebrates. UCPs...

overfeeding. UCP1 activity is stimulated by long chain fatty acids that are produced subsequent to β-adrenergic receptor activation. UCP1 is proposed to...

protein 1 UCP1 has been solved by cryogenic-electron microscopy. The structure has the typical fold of a member of the SLC25 family. UCP1 is locked in...

expression of the fat-burning protein UCP1 that accumulates in fat tissue around the internal organs. Expression of UCP1 protein was significantly increased...

are swimming. This adaptation was largely driven by inactivation of the UCP1 gene - which is under strong purifying selection in most other semi-aquatic...

benefits. Under basal environmental temperatures, HDAC3 primes expression of UCP1 and the brown fat thermogenic program to ensure acute cold survival through...

from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues". Biochemical and Biophysical Research...

Ulla; Andersson, Leif (18 August 2006). "The Uncoupling Protein 1 Gene (UCP1) Is Disrupted in the Pig Lineage: A Genetic Explanation for Poor Thermoregulation...

heat. The process is mediated by a proton channel called thermogenin, or UCP1. Thermogenin is primarily found in brown adipose tissue, or brown fat, and...

evidenced by a transgenic mouse model simulating cetacean-like UCP1 gene inactivation. While UCP1 pseudogenization initiated the development of these phenotypes...

having low metabolic rates compared to other mammals. Changes in the gene UCP1, a gene involved in thermoregulation, can explain differences in the metabolic...

lacking the UCP1 gene revealed that there are no alternative mechanisms for adrenergically induced adaptive thermogenesis apart from UCP1 in brown adipose...

mitochondrial matrix through an uncoupling protein such as thermogenin, or UCP1. Administering oligomycin to rats can result in very high levels of lactate...

oxidative phosphorylation. UCP1 thus controls both the independent and thermogenic metabolisms. Diseases associated with UCP1 include type 2 diabetes and...

of SIRT3 in HIB1B brown adipocytes increases the expression of PGC-1α and UCP1, suggesting a role for SIRT3 in adaptive thermogenesis BAT. BAT is different...

uncoupling protein-1 (UCP1), which proved to be specifically present in brown adipose tissue. He studied the regulation of UCP1 activation and co-authored...

IL-17 will act on the adipocytes uncoupling the protein UCP1, which is required for inducing a UCP1-dependent thermogenic program. Autoimmune disease results...

Ricquier D, Bouillaud F (January 2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP". The Biochemical Journal. 345 (Pt 2): 161–179...

"Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1". Diabetes. 67 (11): 2456–2465. doi:10.2337/db18-0146. PMID 30158241. Liu...

Susanne; Klaus, Susanne (March 2017). "Targeted mitochondrial uncoupling beyond UCP1 – The fine line between death and metabolic health". Biochimie. 134: 77–85...

to the loss of the vertebrate mitochondrial uncoupling protein, UCP1. In mammals, UCP1 functions within brown adipose tissue, which is thermogenic to protect...

glucose intolerance. Mechanistically, N-fatty acyl amino acids function as UCP1-independent uncouplers of mitochondrial respiration. PM20D1 has also been...

transporters in mitochondrial membrane which deplete the proton gradient. UCP1 is highly expressed in brown adipocytes, UCP2 is variably expressed in many...

Methionine-enkephalin peptides produced by ILC2s act directly on adipocytes to upregulate UCP1 and promote emergence of beige adipocytes in white adipose tissue. Beige...

encoded by the UCP2 gene. Chromosomal order is 5'-UCP3-UCP2-3'. In contrast to UCP1 and UCP3, which are primarily expressed in adipose and smooth muscle, UCP2...

(2010). "Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15". Biochem. Biophys. Res. Commun. 400 (1): 175–80. Bibcode:2010BBRC...

increasing UCP1 expression. A 2016 in vitro study of white and brown fat cell tissue found dose-related upregulation of a protein called UCP1 that contributes...

regions and carriers of the TT genotype of the rs3811787 polymorphism of the UCP1 gene. Since this genotype is more prevalent in geographical regions near...

in multiple murine models, and adult humans have significant deposits of UCP1-positive brown fat. (Our data show) that even relatively short treatments...

and show membrane and vacuole CD31 immunoreactivity. Uncoupling protein 1 (UCP1), a unique brown fat mitochondrial protein, is also positive. There are structural...

are consumed to fuel mitochondrial futile cycles and uncoupling protein 1 (UCP1)-dependent respiration to ultimately convert chemical energy to heat. Gs-signaling...

mitochondrial carrier (SLC25A1, SLC25A2, SLC25A3, SLC25A4, SLC25A5, SLC25A6, UCP1(SLC25A7), UCP2(SLC25A8), UCP3(SLC25A9), SLC25A10, SLC25A11, SLC25A12, SLC25A13...

P55089 17842 UCN2 HGNC:18414; Q96RP3 17843 UCN3 HGNC:17781; Q969E3 17844 UCP1 HGNC:12517; P25874 17845 UCP2 HGNC:12518; P55851 17846 UCP3 HGNC:12519; P55916...

Petrovic N, Nedergaard J, Quistorff B, Hansen JB (March 2013). "ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes". Obesity. 21 (3):...

adipogenesis. It promotes differentiation of white adipocytes. It induces UCP1 expression in brown adipose tissue, supporting non-shivering thermogenesis...

fat cells and reduces the production of thermogenic proteins, including Ucp1 and Cidea.  In the inner ear, hepsin driven HGF activation and Met signaling...

from a white-like phenotype into a brown-like phenotype (with induction of UCP1 and able to perform non-shivering thermogenesis, which allows to disperse...

containing this domain include: HDMCP, MCART1, MCART2, MCART6, MTCH1, MTCH2 UCP1, UCP2, UCP3 SLC25A1, SLC25A3, SLC25A4, SLC25A5, SLC25A6, SLC25A10, SLC25A11...

TL, et al. (November 2019). "Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling". Scientific Reports...

a second UCP protein called UCP2, the brown adipocyte UCP being renamed UCP1. He also identified a new cerebral mitochondrial transporter, BMCP, an avian...

Ricquier D, Bouillaud F (Jan 2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP". The Biochemical Journal. 345 Pt 2 (Pt 2):...

A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET (May 2021). "UCP1 governs liver extracellular succinate and inflammatory pathogenesis". Nature...

acid oxidation. One upregulated gene in particular, uncoupling protein-1 (UCP1), has been shown to reduce diet-induced obesity. Studies on AdPLA deficient...