Transdetermination

Transdetermination is a concept in developmental biology to describe the process by which pluripotent stem cells change their fate from becoming one kind of specialized cell lineage to a different lineage. It is contrasted to transdifferentiation where a differentiated cell switches to another lineage without intermediate stages of dedifferentiation.[1] In Drosophila, it has been shown that imaginal disc cells could convert from eye to wing tissue through a factor called winged eye (wge) which induces histone modifications that lead to the altered fate.[2]

References

  1. ^ Manohar, Rohan; Lagasse, Eric (2009). "Transdetermination: A New Trend in Cellular Reprogramming". Molecular Therapy: The Journal of the American Society of Gene Therapy. 17 (6): 936–938. doi:10.1038/mt.2009.93. ISSN 1525-0016. PMC 2835174. PMID 19483768.
  2. ^ Masuko, Keita; Fuse, Naoyuki; Komaba, Kanae; Katsuyama, Tomonori; Nakajima, Rumi; Furuhashi, Hirofumi; Kurata, Shoichiro (2018). "winged eye Induces Transdetermination of Drosophila Imaginal Disc by Acting in Concert with a Histone Methyltransferase, Su(var)3-9". Cell Reports. 22 (1): 206–217. doi:10.1016/j.celrep.2017.11.105. PMID 29298422.


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