TRIM23

TRIM23
Identifiers
AliasesTRIM23, ARD1, ARFD1, RNF46, tripartite motif containing 23
External IDsOMIM: 601747; MGI: 1933161; GeneCards: TRIM23
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.3.2.27↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

373

81003

Ensembl

ENSG00000113595

ENSMUSG00000021712

UniProt

P36406

Q8BGX0

RefSeq (mRNA)

NM_001656
NM_033227
NM_033228

NM_030731
NM_001361538
NM_001361539

RefSeq (protein)

NP_001647
NP_150230
NP_150231

NP_001348467
NP_001348468

Location (UCSC)Chr 5: 65.59 – 65.63 MbChr 13: 104.32 – 104.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.[5][6]

Function

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.[6]

Interactions

TRIM23 has been shown to interact with TRIM31,[7] TRIM29[7] and PSCD1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113595 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021712 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (Apr 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain". The Journal of Biological Chemistry. 268 (12): 8801–7. doi:10.1016/S0021-9258(18)52945-8. PMID 8473324.
  6. ^ a b "Entrez Gene: TRIM23 tripartite motif-containing 23".
  7. ^ a b Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  8. ^ Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (Jul 2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". The Journal of Biological Chemistry. 275 (28): 21331–9. doi:10.1074/jbc.M909642199. PMID 10748148.

Further reading

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