DOSEN PROFIL LENGKAP

p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription...

LFS is caused by germline mutations (also called genetic variants) in the TP53 tumor suppressor gene, which encodes a transcription factor (p53) that normally...

TP53 target 3D is a protein that in humans is encoded by the TP53TG3D gene. GRCh38: Ensembl release 89: ENSG00000205456 – Ensembl, May 2017 "Human PubMed...

individual's age, physical condition, and whether they have the del(17p) or TP53 mutations. CLL is the most common type of leukemia in the Western world....

gene, and most have higher than normal expression of EGFR, whereas the gene TP53 (p53), which is often mutated in glioblastoma, is rarely mutated in this...

relatives. The TP53 tumor suppressor gene specifies a protein that senses damaged sites in DNA, or a cell experiencing stress. The TP53 protein then either...

aberration excluded Hypoplastic MDS, MDS with fibrosis, MDS with bi-allelic TP53 inactivation, and CCUS were added to the WHO 5th ed. Another subtype called...

cancer in Nature in June 2011. The researchers found mutations of the gene TP53 in an overwhelming 96% of the cases analyzed, Recurrent mutations at lower...

the TP53 gene has been deleted) do not develop ovarian carcinomas. However, TP53 mutations were found in 96% of HGSC cases. A local abnormal TP53 expression...

mutations seen in serous carcinoma are chromosomal instability and mutations in TP53, an important tumor suppressor gene. Clear cell carcinoma is a Type II endometrial...

The TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by...

leukemias, are present in most cases and considered the main oncogenic driver. Tp53 are associated with more aggressive disease course. Imaging studies – including...

approximately twice as likely as a control group to have a mutation in the TP53 gene (codon 72 polymorphism). Patients with higher grade tumors exhibited...

maturation arrest (increased erythroblasts) and high prevalence of biallelic TP53 alterations. It is defined as type "M6" under the FAB classification. The...

patients with head and neck squamous cell carcinoma linked to mutations in the TP53 gene. It consists of recombinant adenovirus engineered to code for p53 protein...

genetic mutations include ATM, BRAF, CCND1, DIS3, FAM46C, KRAS, NRAS and TP53. The genetic and epigenetic changes occur progressively. The initial change...

significant link between TP53 mutations and chromothripsis in SHH-MBs has been found. Further studies on the association between TP53 and chromothripsis has...

In molecular biology, TP53 target 1 (non-protein coding), also known as TP53TG1 is a long non-coding RNA. Its expression is induced by p53 under conditions...

Attardi studies the tumor suppressor protein p53 and the gene that encodes it, TP53, to better understand mechanisms for preventing cancer. Laura Donatella Attardi...

divide indefinitely. These cells have a homozygous partial deletion of the TP53 gene and as a result, do not express the tumor suppressor p53 protein which...

chromosome 11 and chromosome 13. Among the documented studies, mutations to the TP53 gene have occurred in 75% of all cases of B-PLL. This is the highest incidence...

majority of adenocarcinomas: KRAS (in 95% of cases), CDKN2A (also in 95%), TP53 (75%), and SMAD4 (55%). The last of these is especially associated with a...

present. These additional mutations include mutations of the tumor suppressor TP53, which interacts with the tumor suppressor p53 (which usually causes apoptosis...

occur for the cell to become cancerous. The p53 protein, produced by the TP53 gene, normally monitors cell division and induces programmed death if Wnt...

of embryonal rhabdomyosarcoma. Tumor suppressor gene mutations, such as TP53 mutations, were shown in about 13% in the mutations and MYOD1 mutations were...

such as frequent loss of certain chromosomes and changes in genes like TP53 and PTEN. Most chRCC cases are found at an early stage and tend to grow slowly...

would call p53 protein "TP53" in humans or "Trp53" in mice, most authors call it "p53" in both (and even refuse to call it "TP53" if edits or queries try...

Brigimadlin (BI-907828) is a small molecule MDM2-TP53 inhibitor developed for liposarcoma. "Brigimadlin". pubchem.ncbi.nlm.nih.gov. Rinnenthal, Joerg;...

Loss-of-function mutations often affect tumor suppressor genes such as NF1, TP53 and CDKN2A. Other oncogenic alterations include fusions involving various...

RET-PTC, NTRK1, PTEN, TP53, PI3K, AKT, CTNNB1, PAX8, RAS, BRAF, TSHR Bladder cancer FGFR3, TERT, STAG2, AURKA Ovarian cancer TP53, WT1, Ki67, Topo-II,...

tumor morphology (grade/stage). On average, cancer tissues with mutated TP53 have a lower age acceleration than those without it. Further, cancer tissues...

positively and negatively regulate transcription. (e.g., NOTCH receptors, TP53 and FAS). Expression of genes, including tumor suppressors, can be altered...

Azacitidine After Allogeneic Hematopoietic Stem-Cell Transplantation for TP53-Mutant Acute Myeloid Leukemia and Myelodysplastic Syndromes". Journal of...

cells are diffusely positive for p53, a pattern consistent with a missense TP53 mutation while the adjacent epithelial cells from the background serous borderline...

shows an abundant stromal reticulin network and presents a high frequency of TP53 gene mutations. Symptoms and signs are similar to those of the ordinary glioblastoma...

that lead to Lynch Syndrome put individuals at risk for ovarian cancer. TP53: Mutations cause Li-Fraumeni syndrome. It produces particularly high rates...

cancer and melanoma. Mutations that inactivate the tumor suppressor genes TP53 and RB are common, as are mutations in CDH1 (involved in metastasis) and...

of chronic lymphocytic leukemia (CLL) in the presence of 17p deletion or TP53 mutation in adults who are unsuitable for or have failed a B cell receptor...

exostoses, increase the risk of osteosarcoma. Li–Fraumeni syndrome (germline TP53 mutation) is a predisposing factor for osteosarcoma development. Rothmund–Thomson...

chromosome arms 1p and 19q indicates the tumor is an oligodendroglioma Loss of TP53 and ATRX characterizes astrocytomas Genes EGFR, TERT, and PTEN, are commonly...

phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively...

experiments yielding data that supported the hypothesis that loss of the TP53 gene, or gain-of-function activities resulting from the expression of its...

deletion (8%) and point mutation (2%) 10% TGF-β mutation/overexpression 12% TP53 mutation/overexpression high-grade serous 20–50% TβRI mutation 33% TβRII...

genes most often mutated are GAK (25.9% of cases), beta-catenin (22.9%), TP53 (22.7%), and ECSIT (19.3%). These genes regulate cell growth and survival...

PMC 4931448. PMID 27374870. Overview of all the structural information available in the PDB for UniProt: Q12888 (TP53-binding protein 1) at the PDBe-KB....

expression of the tumor suppressor TP53 gene by influencing epigenetic modifications to be made to the cancer cells genome. The TP53 gene codes for the p53 protein...

2001 TP44 — October 14, 2001 Socorro LINEAR  · 2.4 km MPC · JPL 156141 2001 TP53 — October 13, 2001 Socorro LINEAR V 870 m MPC · JPL 156142 2001 TB61 — October...

contributes to cell immortality. Mutations in the tumor suppressor gene TP53 are seen in about 30% of cases of HCC. And mutations in Wnt signalling (which...

doi:10.1038/cdd.2017.174. ISSN 1476-5403. PMC 5729533. PMID 29125602. "TP53 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 2020-10-04. Li, Lijuan;...

expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis. Knockout studies in mice suggest that this...

a search for PDX models whose engrafted tumors have amplified KRAS, the TP53 A159V mutation, a deletion of the ALB gene, and high KIT expression. MMHCdb...

A, Makishev A, et al. (November 2020). "Association of polymorphisms in TP53 and the promoter region of IL10 with gastric cancer in a Kazakh population"...

Mohammed A Khan; Curtis C Harris; Pierre Hainaut (1 June 2002). "The IARC TP53 database: new online mutation analysis and recommendations to users". Human...

technique was shown to successfully identify mutations scattered in the TP53 tumor suppressor gene in advanced ovarian cancer patients. The sensitivity...

direction as TP53 and is present in TP53 protein-rich myeloid leukemia cells HL-60 and U937. This suggests a strong relationship to the TP53 gene and subsequent...

very long chain (17p13.1) SHBG: Sex hormone binding globulin (17p13.1) TP53: tumor suppressor protein p53 (Li-Fraumeni syndrome), tumor suppressor gene...

(2013). "Critical analysis of strand-biased somatic mutation signatures in TP53 versus Ig genes, in genome -wide data and the etiology of cancer". ISRN Genomics...

syndrome is an autosomal dominant syndrome primarily caused by mutations in the TP53 gene, which greatly increases the risk of many cancers and is also highly...

allowing them to be heritable. Individuals who inherit germline mutations in TP53 are predisposed to certain cancer variants because the protein produced by...

Figueiredo, Bonald C.; Pappo, Alberto S. (2021-05-01). "The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late...

syndrome will eventually be found to have a small-cell carcinoma of the lung. TP53 is mutated in 70 to 90% of SCLCs. RB1 and the retinoblastoma pathway are...

interacts with ACSL3, APP, DSE, ELAVL1, HECW2, MINOS1, PARK2, SPG20, SUMO2, TP53, TUBGCP3, UBC, UBD, and YWHAQ. GRCh38: Ensembl release 89: ENSG00000068366...

(H3K4). Other reported methylated lysine substrates such as histone H3K9 and TP53 have not been biochemically validated. This enzyme plays a critical role...

inactivation mutation in TP53, have increased risk. Several genes have been shown to be recurrently mutated, including TP53, CTNNB1, MEN1, PRKAR1A, RPL22...

CE IVD kits are available for human clinical diagnostics including BRCA, TP53, PALB2 and CFTR analysis. The technique has also been proven as a useful...

Acute Lymphoblastic Leukemia with High-Risk Molecular Features, Including TP53 Loss". Blood. 134 (Supplement_1): 3888. doi:10.1182/blood-2019-125165. ISSN 0006-4971...

mesothelioma, and may be prognostic factors. These include primarily BAP1, NF2, and TP53; epidermal growth factor receptor (EGFR) and C-Met, receptor tyrosine kinases...

12 through 13.2. This results in the loss of one of the inherited TP53 genes. TP53 encodes tumor suppressor p53, a protein that regulates cell proliferation...

pharmacologically. It is expected that additional markers (e.g., RUNX1, ASXL1, and TP53) that have consistently been associated with an inferior outcome will soon...

deficiency LCAT Lesch–Nyhan syndrome HPRT (X) 1:380,000 Li–Fraumeni syndrome TP53 Limb-Girdle Muscular Dystrophy Multiple dominant or recessive 1:14,500-123...

cancer critical alteration in several genes including (APC (protein)), (TP53), (Beta-catenin|β-catenin) Human APC genome location and APC gene details...

spliceosome components (SF3B1 and SRSF2), or members of the DNA damage response (TP53 and PPM1D). Many people identified as having clonal hematopoiesis have a...

Inactivating mutations in lung SCC affect many tumor suppressor genes such as TP53 (mutated in 81% of cases), MLL2 (20%), CDKN2A (15%), KEAP1 (12%) and PTEN...

enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions". Molecular and Cellular Biology. 26 (24): 9377–86. doi:10.1128/MCB...

107B. doi:10.1016/j.cell.2006.05.036. PMID 16839880. S2CID 15006256. "TIGAR TP53 induced glycolysis regulatory phosphatase [Homo sapiens (human)] – Gene –...

genes. This gene family encodes the proteins: p53 (encoded by the human TP53 gene) p63 (encoded by the human TP63 gene) p73 (encoded by the human TP73...

glycolytic enzymes, including the M2 splice isoform of pyruvate kinase. TP53 mutation hits energy metabolism and increases glycolysis in breast cancer...

at position 22–44 (abbreviated 1-q22–24); genomic alterations around the TP53 tumor suppressor gene at position 13.1 on the short or "p" arm of chromosome...

the expression of Myc leads to tumor formation. The tumor suppressor gene TP53 has also been shown to be regulated by a CPE. Cell lines that do not produce...

the work of Lacroix and Leclercq (2004). For more data on the nature of TP53 mutations in breast cancer cell lines, see Lacroix et al. (2006). Lacroix...

CC, Sanchez CA, Odze RD, et al. (February 2007). "NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma". PLOS...

LCNECs often have inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%). The World Health Organization classification of...

activates certain genes by the tumor suppressor p53. One such gene encodes TP53-inducible glycolysis and apoptosis regulator (TIGAR); an enzyme that inhibits...

cancer. Li-Fraumeni syndrome is caused by a gene alteration on the gene TP53. Cancer types associated with a mutation on this gene include breast cancer...

first group consists of high-penetrance genes, such as BRCA1, BRCA2, and TP53. Mutations in these genes are inherited and significantly increase an individual's...

inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells". Blood. 127 (5): 582–595...

In the absence of hADA3, TP53 transcriptional activity is significantly reduced, suggesting role of hADA3 in activating TP53 function in response to DNA...

neurofibromas is associated with the loss of expression of the CDKN2A or TP53 gene in nonmyelinating Schwann cells that also exhibit biallelic inactivation...

synthesis. p53 inhibits the glycolytic pathway by upregulating the expression of TP53-induced glycolysis and apoptosis regulator. Wild-type p53 supports the expression...

mapped. Some examples are 17p13 loss in multiple cancer types where a copy of TP53 gene gets inactivated, 13q14 loss in retinoblastoma with RB1 gene deletion...

the dynamics of emergency granulopoiesis, as demonstrated by studies in TP53 haploinsufficient models, particularly in FANCC−/− mice, highlighting the...

phenotype as Phaeochromocytoma. There are different mutations such as BRAF, TP53, PTEN, RB1, epidermal growth factor receptor (EGFR) and ERBB2 observed in...

mutation patterns. In HPV-negative disease, genes frequently mutated include TP53, CDKN2A and PIK3CA. In HPV-positive disease, these genes are less frequently...

acids are thought to be a result of mutation of the tumor suppressor gene TP53, which seems to be unique to aristolochic acid-associated carcinogenesis...

colorectal carcinomas, most notably mutations in the tumor suppressor genes TP53 and APC, and in the oncogene BRAF. Specifically, HT-29 cells overproduce...

cases, sarcoma may be related to a rare inherited genetic alteration of the TP53 gene and is known as Li-Fraumeni syndrome. Certain other inherited diseases...

— October 12, 2006 Kitt Peak Spacewatch  · 2.5 km MPC · JPL 216183 2006 TP53 — October 12, 2006 Kitt Peak Spacewatch  · 2.9 km MPC · JPL 216184 2006 TT60...

of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations". Acta Neuropathologica. 124 (5): 615–625. doi:10.1007/S00401-012-1031-3...

PMID 17486094. S2CID 22103978. "Entrez Gene: RRM2B ribonucleotide reductase M2 B (TP53 inducible)". Copeland WC (2012). "Defects in mitochondrial DNA replication...

hereditary breast and ovarian cancers; ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2 and TP53, found 15,311 DNA sequence variants in only 102 patients. Many of those 15...

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene. This protein is a serine/threonine protein kinase...

through its ability to regulate Notch and TP53. Numb binds and inhibits the E3-ligase Mdm2 that is responsible for TP53 ubiquitination and degradation. The...

have an even larger role in carcinogenesis than mutations. Only one gene, TP53, is mutated in more than 20% of liver cancers, while 41 genes each have hypermethylated...

microbiome – TP53 mutation interaction in human lung cancer, Genome Biology:19: 123–29, 2018. Decades prior to the recent discovery of mutant TP53 cells in...

Function Mutation type Influence on cell function Clinical impact on ENKTCL-NT TP53 p53 13–62% tumor suppressor gain promotes cell proliferation, survival, migration...

results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. NEK6 has been shown to interact with NEK9...

Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations". Cancer Discovery. 4 (11): 1342–1353. doi:10.1158/2159-8290.CD-14-0622...

encoding p53 (TP53) was thought to be an oncogene rather than a tumor suppressor gene. In 1989, Vogelstein and his students discovered that TP53 not only played...

Seymour M, Maughan TS (20 November 2021). "Inhibition of WEE1 Is Effective in TP53 - and RAS -Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C)...

used to grow Sabin oral polio vaccine. The TAg has a CUL7-binding domain, a TP53-binding domain, a Zinc finger, and a Superfamily 3 ATPase/Helicase domain...

SE, Nikolova O, Liu T, Jones CL, D'Alessandro A, et al. (July 2019). "The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition...

ENSG00000197579 Unknown Known motif – In vivo/Misc source [979] TCCCAGCTACTTTGGGA TP53 ENSG00000141510 p53 Known motif – In vivo/Misc source [980] DRCATGYYBRGRCATGYCY...

mutations in ARID5B, CDKN2A/2B, CEBPE, IKZF1, GATA3, PIP4K2A and, more rarely, TP53. These genes play important roles in cellular development, proliferation...

genetic markers that have been related to this disease, such as TP53 and MYCN, where TP53 correlates to an overall poorer prognosis. The most common form...

Miki Y, Yoshida K (2007). "Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by Controlling Death-Promoting Factor Btf in the Apoptotic...

environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase...

of other genetic alterations in ISMCL B-cells. Deletions and mutations of TP53 (located on the short (i.e. "p") arm of chromosome 17 at position p13.1 (i...

altered with similar predicted functional consequence in other tumour types. TP53, SYNE1, and ARID1A are among the most frequently mutated genes. Notably,...

"Progressive leukemic non-nodal mantle cell lymphoma associated with deletions of TP53, ATM, and/or 13q14". Annals of Diagnostic Pathology. 18 (4): 214–219. doi:10...

Julie A.; Harris, Curtis C. (2018). "Interaction between the microbiome and TP53 in human lung cancer". Genome Biology. 19 (1). doi:10.1186/s13059-018-1501-6...

neoplastic cells contain various gene and chromosome abnormalities: the TP53 gene is deleted or mutated in 17–60% of cases; the RB1 gene is deleted in...

gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD finger...

causing a MDM2 amplification on the q arm of chromosome 12, which inhibits TP53 gene (a crucial tumor suppressor), resulting in rapid growth of a bone tumor...

allows assessment of other key loci in glial tumors, such as EGFR (EGFR) and TP53 copy number status. Whereas the prognostic relevance of 1p and 19q deletions...

larger role in this carcinogenesis than mutations. Only one or two genes, TP53 and perhaps ARID1A, are mutated in more than 20% of liver cancers while 41...

CLL/SLL cells which develop deletions in the CDKN2A gene, disruptions of the TP53 gene, activation of the C-MYC gene, trisomy (i.e. extra) chromosome 12, or...

Yeager M, Burdett L, et al. (December 2007). "Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer"...

improve treatment and patient outcome. His team discovered a ubiquitous TP53 mutation in high grade serous ovarian cancer (HGSOC), the most common form...

only one exon in the translated mRNA sequence. The tumor suppressor gene TP53 was also found within the gene neighborhood of MFSD6L at 17p13.1. The MFSD6L...

representing a different subtype of acute myeloid leukemia (HL60 – AML M2 with TP53 deletion and CDKN2AC238T, Kasumi-1 – AML M2 with AML1-ETO fusion gene and...

adenocarcinoma affect many oncogenes and tumor suppressor genes, including TP53 (mutated in 46% of cases), EGFR (27%), KRAS (32%), KEAP1, STK11 and NF1....

and depends on cyclins to be passed. One of the most important of these is TP53, a gene which produces a family of proteins known as p53. It, combined with...

CREB1, HIF1α, JUN, KLF6, KLF7, MYC, SMAD1, SMAD2, SMAD3, SOX11, SRF, STAT3, TP53, and XBP1. Several of these can also boost the regenerative capacity of CNS...

11–25%). Elephant genomes include tp53, a gene that encodes apoptosis-inducing protein p53. Humans have two copies of tp53—one from each parent. If one copy...

mutations PI3KCA MAPK3K1 GATA3 CCDN1 amplification Similar to luminal A but: TP53 inactivation Rb inactivation Myc-related transcription FOXM1-related transcription...

among Palestinian women: Genetic heterogeneity and a founder mutation in TP53". International Journal of Cancer. 141 (4): 750–756. doi:10.1002/ijc.30771...

Anticancer Res. 20 (5A): 2801–2809. PMID 11062687. "Entrez Gene: PERP PERP, TP53 apoptosis effector". Roberts O, Paraoan L (Dec 2020). "PERP-ing into diverse...

cycle progression is halted to prevent propagation of the mutation. The TP53 gene (also known as p53) is crucial in ensuring the conservation of the genome...

recurrent genetic alterations reported in acinic cell carcinoma include: TP53 mutations (15-20% of cases), particularly in high-grade or dedifferentiated...

Zambetti GP, Ribeiro RC, Murphy ME, Maxwell KN (September 2020). "A Rare TP53 Mutation Predominant in Ashkenazi Jews Confers Risk of Multiple Cancers"...

KRAS mutations among others. TP53 mutational status appears to have an impact on prognosis and resistance mechanisms, with TP53-mutated tumors showing shorter...

Schlessinger D, Nagaraja R (September 2013). "T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts"...

chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) without TP53 aberrations". Journal of Clinical Oncology. 41 (16_suppl) TPS7594. doi:10...

unique in that it is not derived from MMR, and it is commonly associated with TP53 mutations. EMAST is seen in a variety of cancers including those of the lung...

fusion gene in a single case, and, in individual cases, mutations in the TP53, RB1, CDKN2A and HRAS tumor suppressor genes. Further studies are needed...

Wendi (2016-12-20). Mardis, Elaine Rene (ed.). "Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for...

in The Tiger (1978 film); also the original name of the film TIGAR, the TP53-inducible glycolysis and apoptosis regulator protein All pages with titles...

gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger...

called serous endometrial intraepithelial carcinoma. Mutation is found in TP53 gene which is a tumor suppressor gene even in precursor lesion suggesting...

underlying faster and more frequent recurrence of the disease" Presence of TP53 mutations, a marker for HPV- OPC, is associated with worse prognosis. High...

Li–Fraumeni syndrome is an inherited condition that leads to mutations in TP53, a tumour suppressor gene, thereby increasing the risk of T-ALL. Mutations...

TFDP1, CDC25A Negative regulators: E2F7, RB1, TP107, TP21 Checkpoints: TP53, BRCA1,2, BUB1 Apoptosis: TP73, APAF1, CASP3,7,8, MAP3K5,14 Nucleotide synthesis:...

syndrome and malignant rhabdoid tumors. A mutation in the tumor suppressor gene TP53 is usually characterized in this disease. Choroid plexus carcinomas typically...

growth via its interactions. ASPP2 regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in...

The TP53 gene on chromosome 17 suppresses cancer cells, while oncogenes stimulate cell growth and can cause cancer if kept switched on, while TP53 can...

harboring risk variants for many types of cancer, and variants in the TERT, TP53 and LG24 genes as risk factors for multiple cancers.   deCODE has discovered...

are some GeneRIFs taken from Entrez Gene for GeneID 7157, the human gene TP53. The PubMed document identifiers have been omitted from the examples. Note...

loss of a BRCA gene imposes an increased risk of breast and ovarian cancer. TP53 – A tumor suppressor gene that is mutated in High grade serous carcinoma...

potential tumor growth modulating mechanisms in cells having different status of TP53 gene. In 2020 he was awarded the habilitation (D.Sc.) in biomedical engineering...

including 32 co-complex interactions. POLG appears to interact with POLG2, Dlg4, Tp53, and Sod2. Prince Frederick of Luxembourg (2002-2025) GRCh38: Ensembl release...

Adiponectin deficiency; 612556; ADIPOQ Adrenal cortical carcinoma; 202300; TP53 Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency; 202010;...

CD56+ and HLA-DR+) and they carry the same point mutation in exon 7 of the TP53 (p53) gene with the difference that they lack CD57 and CD1 but expresses...

mutations of glioblastoma (GBM), such as 1p/19q deletion, MGMT methylation, TP53, EGFR, and NF1, have been shown to be significantly predicted by magnetic...

Thus, tumor suppressor genes can be recognized as antimutagenic agents. TP53: This gene encodes for the p53 protein, which is known to act on the apoptotic...

Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide...

Margison GP, Forster G, et al. (October 1999). "Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors". American Journal...

severalfold. Identified Cancer Predisposition Syndromes Li–Fraumeni syndrome (TP53) Hereditary breast or ovarian cancer (BRCA 1⁄2) Colorectal cancer/polyposis...

component being investigated. One of the most prevalent mutations in CPTs is the TP53 R248W mutation. Signs of the tumor resulting from increased intracranial...

lost and drug resistance occurs by losing tumor suppressor genes such as TP53. Genomic instability can occur when the replication fork is disturbed or...

(2015-07-01). "Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data"...

of the membrane protein PERP. TP63 can also regulate PERP expression with TP53 in human cancer. In oocytes, a unique quality control system has evolved...

N, Rice G, Quinn M, Baker M, and Campbell I. "Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas". Molecular Carcinogenesis 2003, 37:61–4...

primer placement) could be successfully employed to detect mutations in the TP53 gene, which encodes the tumour suppressor protein p53 in clinical samples...

ANKRD1 has been shown to interact with: Titin, MYPN, YBX1, CASQ2, DES, TP53, TLN1, and FHL2. GRCh38: Ensembl release 89: ENSG00000148677 – Ensembl, May...

Olivier M, Hussain SP, Caron de Fromentel C, Hainaut P, Harris CC (2004). "TP53 mutation spectra and load: a tool for generating hypotheses on the etiology...

checkpoint kinases might lead to increased cancer risk. Gene mutations in TP53 might also enable malignant growth by inhibiting apoptosis and cell-cycle...

(22): 6202–5. PMID 1933879. Eibl RH, Schneemann M (February 2023). "From TP53 Mutations to Molecular Classification and Liquid Biopsy". Biology. 12 (2):...

bp mRNA linear PRI 12-JUN-2025 DEFINITION Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. LOCUS NM_001354689 3251 bp mRNA linear PRI...

RNA splicing patterns, resulting in modulation of the p53 (also known as TP53) signalling pathway and apoptosis. m6A is also found on the RNA components...

tumors with patterns of mutation in TP53 and CDKN2A in order to show that patterns of hotspot mutations in TP53 differed depending on the presence or...

Czernuszewicz, G., Taylor, M. R., ... & Marian, A. J. (2019). DNA damage response/TP53 pathway is activated and contributes to the pathogenesis of dilated cardiomyopathy...

relationship with TP53 miRNA Effect Inhibitory effect of an miRNA on its mRNA target miR-30 has a negative "miRNAEffect" relationship with TP53 Promoter Binding...

Guervós MA, Marcos CA, Hermsen M, et al. (2007). "Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx...

intervention in patients with AML MRD may improve survival, that low-level TP53 mutations are detectable pre-transplantation in patients with sickle cell...

"Receptor based virtual screening of potential novel inhibitors of tigar [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator". Medical...

system in HAP1 is partially functional with a known point mutation in the TP53 gene. Knocking out p53 also results in a small but measurable increase in...

for Structures Swiss-model Domains InterPro ribonucleotide reductase M2 B (TP53 inducible) Identifiers Symbol RRM2B NCBI gene 50484 HGNC 17296 OMIM 604712...

control cancer risk in humans: an unexpected twist in the basic biology of TP53". Endocrine-Related Cancer. 25 (11): R497–R517. doi:10.1530/ERC-18-0241....

senescence pathway. p53 is a tumor suppressor protein encoded by the human gene TP53 whose function is to prevent unregulated cell growth. p53 can be activated...

subunit 4I1 (COX4I1), estrogen receptor 1 (ESR1), and tumor protein p53 (TP53). Metoprine is well-absorbed and widely distributed across various tissues...

Román-Gómez J, Jiménez-Velasco A, et al. (2006). "ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic...

finger protein 839 was found to have the following interacting proteins: TP53 (Tumor Protein p53), YWHAE (14-3-3 Protein Epsilon), YWHAZ (Tyrosine-3-monooxygenase)...

hardest-to-treat diseases, such as Alzheimer's disease, many forms of cancer (e.g., TP53), and human immunodeficiency virus (HIV) infection involve protein–protein...

anti-apoptotic impacts in human extravillous trophoblasts, mediated by the TP53 gene. Apoptosis is a controlled cell death process that must not occur if...

deoxyribonucleoside diphosphates. The version of R2 encoded by RRM2B is induced by TP53, and is required for normal DNA repair and mtDNA synthesis in non-proliferating...

Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide...

defective, PTEN protein interacts with the protein of a second gene known as Tp53 to dampen energy production in neurons. This severe stress leads to a spike...

transcriptomics identified regulated transcription factors such as SP1 and TP53. These transcription factors were more precisely identified by bioinformatics...

This allows assessment of other key loci in glial tumors, such as EGFR and TP53 copy number status.[citation needed] Whereas the prognostic relevance of...

made important contributions in the characterization of pathways (such as TP53) involved in these critical cellular processes. He has been a pioneer in...

Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide...

TK51 — October 2, 2008 Kitt Peak Spacewatch  · 1.7 km MPC · JPL 378855 2008 TP53 — March 26, 2006 Mount Lemmon Mount Lemmon Survey  · 1.9 km MPC · JPL 378856...

carcinoma. ANKRD2 has been shown to interact with Titin YBX1, TCAP, PML and TP53. Lamin A and prelamin A Akt. GRCh38: Ensembl release 89: ENSG00000165887...

moderate-low moderate-high high very high IPSS-M determined that multihit TP53 mutations, FLT3 mutations, and partial tandem duplication mutations of KMT2A...

interacts with ACSL3, APP, DSE, ELAVL1, HECW2, MINOS1, PARK2, SPG20, SUMO2, TP53, TUBGCP3, UBC, UBD, and YWHAQ. GRCh38: Ensembl release 89: ENSG00000151726...

and hMLH1 and its relationship to corresponding protein expression and TP53 mutations in human esophageal squamous cell carcinoma". Medical Oncology...

Of Somatic Mutations In Cancer homepage WTSI page describing COSMIC IARC TP53 database Cancer genome anatomy project at the National Cancer Institute Atlas...

also participates in cell transformation by MYC. It is required for p53/TP53-, E2F1-, and E2F4-mediated transcription activation. It is also involved...

2000 TF8 — October 1, 2000 Socorro LINEAR (5) 920 m MPC · JPL 469345 2000 TP53 — October 1, 2000 Socorro LINEAR  · 2.5 km MPC · JPL 469346 2000 TN64 — October...

PMID 28594745. S2CID 28223281. Song CV, Teo SH, Taib NA, Yip CH (2018). "BRCA, TP53 and PALB2: a literature review". ecancermedicalscience. 12: 863. doi:10.3332/ecancer...

excessive copies of chromosome 21 genes. The genes with these mutations include TP53, FLT3, ERG, DYRK1A, CHAF1B, HLCS, RUNX1, MIR125B2 (which is the gene for...

gene in 64% of cases and reports of mutations in JAK1, JAK3, DNMT3A, and TP53 genes. The development of BIA-ALCL, it has often been suggested, may be at...

mispaired to 8-oxoG, while OGG1 detects and acts on 8-oxoG, removing it. TP53 transcriptionally regulates MUTYH and may potentially act as a regulator...

functions as a tumor suppressor protein; 2) deletions and/or mutations in the TP53 gene that encodes tumor protein P53 (a protein which regulates cell proliferation...

2367–2380. doi:10.1101/gad.202201. ISSN 0890-9369. PMC 312780. PMID 11562347. TP53 Glucocorticoid receptor India portal Biology portal Medicine portal Please...

nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement...

and has tumor suppressor activity to thereby promote cellular survival; 3) TP53 (14% of cases), a transcription factor that indirectly regulates cell proliferation...

Oki E, et al. (June 2016). "Reduced MUTYH, MTH1, and OGG1 expression and TP53 mutation in diffuse-type adenocarcinoma of gastric cardia". Human Pathology...

PPP1R13L, PRKCZ, REL, RFC1, RNF25, SIRT1, SOCS1, SP1, STAT3, TAF4B, TBP, TP53, and TRIB3. Gene knockout of NF-κB genes via homologous recombination in...

The mutations occur in one or, more commonly, multiple genes including: TP53, RUNX1, FLT3, ERG, DYRK1A, CHAF1B, HLCS, CTCF, STAG2, RAD21, SMC3, SMC1A...

abnormalities are associated with the disease: 1) mutations in NRAS, ASXL1, and TP53; 2) deletions of the CDKN2A-ARF-CDKN2B locus on the short arm of chromosome...

References External links p53 A class of regulatory proteins encoded by the TP53 gene in vertebrates which bind DNA and regulate gene expression in order...

facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation...

methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML". Blood. 142 (23): 2002–2015. doi:10.1182/blood.2023019782. PMID 37738460...

mutations, vimentin) Hepatocellular carcinoma (HCC)-associated HBV mutation, TP53 mutation) Cervical cancer (HPV DNA) Cancer monitoring Bladder cancer (FGFR3...

genes other than thyroid-specific. Several known tumor suppressor genes like TP53 and WT1 have been identified as transcriptional targets in human astrocytoma...

Integrative Molecular Analysis Reveals Determinants of Clinical Outcomes in TP53-Mutated Diffuse Large B-Cell Lymphoma. J Clin Oncol. 2026 Apr 29:JCO2501928...

Nishida Y, et al. (November 2025). "Restoring p53 wild-type conformation in TP53-Y220C-mutant acute myeloid leukemia". Blood. 146 (21): 2574–2588. doi:10...

therapies. R-FCM should not be considered in patients with a 17p deletion, a TP53 mutations, and in patients with unmutated immunoglobulin heavy chain variable...

2002 TF53 — October 2, 2002 Socorro LINEAR  · 4.9 km MPC · JPL 84334 2002 TP53 — October 2, 2002 Socorro LINEAR  · 7.0 km MPC · JPL 84335 2002 TR53 — October...

of chromosome 12; and mutations in NOTCH1, BIRC3, SF3B1, MYD88, ATM, and TP53 genes. In general, the presence and frequency of the mutations in high count...

Italy) – includes one p53 track p53 is actually a protein encoded by the Tp53 gene, but the p53 CD liner-notes refer to it as a gene. p53 CD liner-notes...

September 27, 2003 Kitt Peak Spacewatch  · 1.5 km MPC · JPL 669119 2012 TP53 — April 3, 2011 Haleakala Pan-STARRS 1  · 1.5 km MPC · JPL 669120 2012 TR54...

hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate...

DA, Siafakas NM, Spandidos DA (2003). "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis". J. Cell...

— October 4, 2007 Kitt Peak Spacewatch MIS 2.2 km MPC · JPL 300445 2007 TP53 — October 4, 2007 Kitt Peak Spacewatch  · 1.7 km MPC · JPL 300446 2007 TK54...

expansion. Clonal expansions are most often associated with the loss of the p53 (TP53) or p16 (CDKN2A/INK4a) tumor suppressor genes. In lung cancer, a clone with...

Q96NM4 17228 TOX3 HGNC:11972; O15405 17229 TOX4 HGNC:20161; O94842 17230 TP53 HGNC:11998; P04637 17231 TP53AIP1 HGNC:29984; Q9HCN2 17232 TP53BP1 HGNC:11999;...

gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger...

hypermethylation, this includes the promoters of the genes CDKN2/p16, RB, PTEN, TP53 and p14ARF. Importantly, glioblastomas are known to have high frequency of...

PIK3CA Mutation <5 AKT3 Amplification 40- 60 Tumor Suppressor Genes INK4A Mutation 40- 87 ARF Mutation 40- 70 PTEN Mutation 5- 40 TP53 Mutation 0- 25...

transient disorder to AMKL. The mutations occur in one or more genes including: TP53, FLT3, ERG, DYRK1A, CHAF1B, HLCS, RUNX1, MIR125B2 (which is the gene for...

to other more aggressive types of cancer. ZR-75-1 possesses a wild type TP53 gene, a somewhat unusual trait among cancer cells. However, it does contain...

apoptosis by up-regulating cyclin-D1 expression through the suppression of p53/TP53 phosphorylation. Protein phosphatase 2A is one of the four major Ser/Thr...

histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. PPIB peptidylprolyl isomerase B crosslinking mass spectrometry BioGRID...

October 7, 2005 Andrushivka Andrushivka  · 1.4 km MPC · JPL 388058 2005 TP53 — October 1, 2005 Catalina CSS LIX 4.5 km MPC · JPL 388059 2005 TA64 — October...

neddylation substrates include signaling molecules such as tumor suppressors TP53 and TP73, E2F transcription factors, epidermal growth factor receptor (EGFR)...

Protein Name Function Localization ZNF385B Zinc finger 385B Role in p53/TP53-mediated apoptosis. Nucleus ZNF827 Zinc finger 827 Involved in transcriptional...

Lu Y, Fogarty J, Rossi S, et al. (Feb 2010). "miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha...

enzyme UBC9 are downregulated by miR-30. It has also been suggested that the TP53 protein may be a target of miR-30c and miR-30e. An immunoblot analysis revealed...

exact mechanisms involved are not yet clearly defined. Tumor protein p53 (TP53, often referred to as p53) regulates a sophisticated network of tumor-suppressive...

Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide...

with PACB were the PIK3CA gene in 12, PTEN tumor suppressor gene in 6, and TP53 tumor suppressor gene in 5 individuals. Less commonly, these cells had mutations...

(MLL) MYB (c-Myb) NFE2 (NF-E2 p45) RELA (NF-κB p65) SREBP STAT1 TCF3 (E2A) TP53 (p53) YY1 Yeast proteins: Gal4p Gcn4 Pdr1 Pdr3 Oaf1 Viral proteins: Regulatory...

may have mutations or other genetic abnormalities in their STAT5B, JAK3, TP53, SETD2, BRAF, KRAS, GNA12, CREBBP, and/or Myc genes. Indolent T cell lymphoproliferative...

K, Sudo T, Yokobori T, Eguchi H, et al. (October 2013). "PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression". British Journal...

tumors was shown to be associated with mutations in the tumor suppressor gene TP53. After the discovery of the Icelandic BRCA2 founder mutation Jórunn and her...

Common HRAS Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases". American Journal of...

in PB-EPCs when compared to CB-EPCs. PB-EPCs have more tumor suppressor (TP53) expression when compared to CB-EPCs. CB-EPCs have more angiogenic expression...

because of genetic mutations in EGFR, KRAS, STK11 (also known as LKB1), TP53 (also known as p53), and CDKN2A (also known as p16 or INK4a) with the most...

endometrial mutY homolog (E. coli) MUTYH BER of A paired with 8-oxo-dG colon TP53 P53 Direct role in HRR, BER, NER and acts in DNA damage response for those...

Alder H, Kaur B, Aqeilan RI, Pichiorri F, Croce CM (April 2012). "MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme". Proceedings of the National...

September 14, 2014 Kitt Peak Spacewatch HNS 960 m MPC · JPL 557176 2014 TP53 — September 18, 2003 Palomar NEAT  · 940 m MPC · JPL 557177 2014 TZ53 — November...

species-mediated cytotoxicity preferentially to cancer cells with mutant TP53". Oncogene. 37 (21): 2793–2805. Bibcode:2018Oncog..37.2793L. doi:10.1038/s41388-018-0130-6...

OTUB1. RNF128 interacts with many other different proteins including CD81, TP53, USP8, USP7, TBK1, and CD151. The NSP7+NSP8 hexadecamer super complex is...

mutations in TP53 (Li–Fraumeni syndrome), ATM (ataxia–telangiectasia), STK11/LKB1(Peutz–Jeghers syndrome), PTEN (Cowden syndrome). RAB11FIP1, TP53, PTEN and...

"Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation". Oncogene. 22 (34): 5358–61. doi:10...

Rochester Medical Center identify four genes – KRAS, CDKN2A, SMAD4, and TP53 – responsible for how long patients survive with pancreatic cancer. Researchers...

up-regulated in most ependymomas, correlating with poor outcome. While p53 (TP53) mutations are not often observed in pediatric ependymoma, the p53 pathway...

11, 2005 Mount Lemmon Mount Lemmon Survey  · 3.3 km MPC · JPL 415451 2013 TP53 — May 9, 2002 Kitt Peak Spacewatch  · 2.4 km MPC · JPL 415452 2013 TP65 —...