TMX1

TMX1

Identifiers

TMX1, PDIA11, TMX, TXNDC, TXNDC1, thioredoxin related transmembrane protein 1

External IDs

OMIM: 610527; MGI: 1919986; GeneCards: TMX1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1X5E

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
5.3.4.1	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q22.1	Start	51,240,162 bp^[1]
Band	14q22.1	End	51,257,655 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 C2	Start	70,499,869 bp^[2]
Band	12\|12 C2	End	70,514,814 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tibia

skin of hip

mucosa of sigmoid colon

germinal epithelium

trabecular bone

oral cavity

skin of thigh

jejunal mucosa

superficial temporal artery

secondary oocyte

Top expressed in

retinal pigment epithelium

cumulus cell

ciliary body

epithelium of lens

Paneth cell

fossa

condyle

Epithelium of choroid plexus

aortic valve

supraoptic nucleus

More reference expression data

n/a

Gene ontology
Molecular function	disulfide oxidoreductase activity protein disulfide isomerase activity
Cellular component	integral component of membrane membrane endoplasmic reticulum membrane endoplasmic reticulum
Biological process	protein folding response to endoplasmic reticulum stress cell redox homeostasis
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


81542


72736


ENSG00000139921


ENSMUSG00000021072


Q9H3N1


Q8VBT0

RefSeq (mRNA)


NM_030755


NM_028339

RefSeq (protein)


NP_110382


NP_082615

Location (UCSC)

Chr 14: 51.24 – 51.26 Mb

Chr 12: 70.5 – 70.51 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Thioredoxin-related transmembrane protein 1 is a protein that in humans is encoded by the TMX1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139921 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021072 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsuo Y, Akiyama N, Nakamura H, Yodoi J, Noda M, Kizaka-Kondoh S (Mar 2001). "Identification of a novel thioredoxin-related transmembrane protein" (PDF). J Biol Chem. 276 (13): 10032–8. doi:10.1074/jbc.M011037200. PMID 11152479.
^ "Entrez Gene: TXNDC1 thioredoxin domain containing 1".

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

v t e PDB gallery
1x5e: The solution structure of the thioredoxin-like domain of human Thioredoxin-related transmembrane protein

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