TIMM22

TIMM22

Identifiers

TIMM22, TEX4, TIM22, translocase of inner mitochondrial membrane 22 homolog (yeast), translocase of inner mitochondrial membrane 22, COXPD43

External IDs

OMIM: 607251; MGI: 1929742; GeneCards: TIMM22

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17p13.3	Start	997,129 bp^[1]
Band	17p13.3	End	1,003,671 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B5	Start	76,297,778 bp^[2]
Band	11\|11 B5	End	76,307,118 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

apex of heart

gonad

left ventricle

islet of Langerhans

gastrocnemius muscle

muscle of thigh

placenta

right auricle of heart

prefrontal cortex

stromal cell of endometrium

Top expressed in

morula

morula

facial motor nucleus

medial ganglionic eminence

endocardial cushion

neural tube

blastocyst

motor neuron

renal corpuscle

fossa

More reference expression data


More reference expression data

Gene ontology
Molecular function	mitochondrion targeting sequence binding protein binding protein transmembrane transporter activity
Cellular component	integral component of membrane mitochondrial inner membrane membrane mitochondrion TIM22 mitochondrial import inner membrane insertion complex
Biological process	protein transport protein targeting to mitochondrion protein insertion into mitochondrial inner membrane protein transmembrane transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


29928


56322


ENSG00000277649 ENSG00000278501 ENSG00000177370


ENSMUSG00000020843


Q9Y584


Q9CQ85

RefSeq (mRNA)


NM_013337


NM_001291161 NM_019818 NM_023355

RefSeq (protein)


NP_037469


NP_001278090 NP_062792 NP_075844

Location (UCSC)

Chr 17: 1 – 1 Mb

Chr 11: 76.3 – 76.31 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim22 is an enzyme that in humans is encoded by the famous TIMM22 gene.^[5]

See also

References

^ ^a ^b ^c ENSG00000278501, ENSG00000177370 GRCh38: Ensembl release 89: ENSG00000277649, ENSG00000278501, ENSG00000177370 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020843 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kovermann P, Truscott KN, Guiard B, et al. (2002). "Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel". Mol. Cell. 9 (2): 363–73. doi:10.1016/S1097-2765(02)00446-X. PMID 11864609.
Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480. S2CID 27484018.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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