Synergin gamma

SYNRG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYNRG, AP1GBP1, SYNG, synergin, gamma, synergin gamma
External IDsOMIM: 607291; MGI: 1354742; HomoloGene: 105680; GeneCards: SYNRG; OMA:SYNRG - orthologs
Orthologs
SpeciesHumanMouse
Entrez

11276

217030

Ensembl

ENSG00000275066
ENSG00000274047

ENSMUSG00000034940

UniProt

Q9UMZ2

Q5SV85

RefSeq (mRNA)

NM_001115009
NM_194341

RefSeq (protein)
Location (UCSC)Chr 17: 37.51 – 37.61 MbChr 11: 83.86 – 83.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG gene.[5][6]

Function

This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene.[6]

Interactions

AP1GBP1 has been shown to interact with AP1G1[7][8] and SCAMP1.[9]

References

  1. ^ a b c ENSG00000274047 GRCh38: Ensembl release 89: ENSG00000275066, ENSG00000274047 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034940 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Page LJ, Sowerby PJ, Lui WW, Robinson MS (October 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". J. Cell Biol. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
  6. ^ a b "Entrez Gene: AP1GBP1 AP1 gamma subunit binding protein 1".
  7. ^ Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (July 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
  8. ^ Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
  9. ^ Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (April 2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.

Further reading


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