Splicing factor

A splicing factor is a protein involved in the removal of introns from strings of messenger RNA, so that the exons can bind together; the process takes place in particles known as spliceosomes. Splicing factors regulate the binding of the snRNPs U1 and U2 to the 3' and 5' ends of the intron during splicing and can either be splicing promoters or splicing repressors.[1]

In a research paper, splicing factors were found to be produced upon application of resveratrol analogues, which induced senescent cells to rejuvenate.[2][3] The expression of splicing factors may be altered during aging.[4]

Splicing factor 3b

Splicing factor 3b is a protein complex consisting of the following proteins: PHF5A, SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6.[citation needed]

Notes

  1. ^ Wang, Z; Burge, CB (May 2008). "Splicing regulation: from a parts list of regulatory elements to an integrated splicing code". RNA. 14 (5): 802–13. doi:10.1261/rna.876308. PMC 2327353. PMID 18369186.
  2. ^ The University of Exeter (17 November 2017). "Old human cells rejuvenated in breakthrough discovery on ageing". MedicalXpress.com. Retrieved 29 January 2025.
  3. ^ Latorre E, Birar VC, Sheerin AN, Jeynes JC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RG, Ostler EL, Harries LW (2017). "Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence". BMC Cell Biology. 18 (1) 31. doi:10.1186/s12860-017-0147-7. PMC 5645932. PMID 29041897.
  4. ^ Wang K, Wu D, Zhang H, Das A, Basu M, Malin J, Cao K, Hannenhalli S (2018). "Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases". Scientific Reports. 8 (1) 10929. Bibcode:2018NatSR...810929W. doi:10.1038/s41598-018-29086-2. PMC 6053367. PMID 30026530.


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