DOSEN PROFIL LENGKAP

Sortilin is a protein that in humans is encoded by the SORT1 gene on chromosome 1. This protein is a type I membrane glycoprotein in the vacuolar protein...

Sortilin-related receptor (SORLA) is a protein that in humans is encoded by the SORL1 gene. SORLA, is a 2214 residue type I transmembrane protein. SORLA...

surface expression of low-affinity nerve growth factor receptor (p75). Sortilin is required for many apoptosis-promoting p75NTR reactions, functioning...

and survival of the target neuron. High affinity binding between proNGF, sortilin, and p75NTR can result in either survival or programmed cell death (PCD)...

The SorCS2 (sortilin-related Vps10p domain containing receptor 2) gene is found on chromosome 4 (4p16.1), and is composed of 28 exons. The N-terminal exons...

and Bak. The importance of sortilin in p75NTR-mediated apoptosis is exhibited by the fact that the inhibition of sortilin expression in neurons expressing...

G protein-coupled receptors, while the third receptor, called NTS3 or Sortilin, is a single transmembrane domain receptor encoded by the gene SORT1. It...

PCSK9 co-localizes with the protein sortilin on its way through the Golgi and trans-Golgi complex. A PCSK9-sortilin interaction is proposed to be required...

rs13426725. Other variants that increase the risk of AD include rs6733839. Sortilin-related receptor 1 (SORL1) is a 250-kDa membrane protein with seven distinct...

sleep-wake cycles, and dopamine. NTS3 is identical to the sorting protein sortilin and possesses many other functions outside the central nervous system....

Vægter CB, Brady OA, Zheng Y, Mackenzie IR, et al. (November 2010). "Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein...

ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, et al. (June 2005). "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to...

amino acid change occurs on the portion of the prodomain where sortilin binds; and sortilin is essential for normal trafficking. The Val66Met mutation results...

SORL1 (which is also a receptor for other cargo proteins such as APP), and sortilin. Early study on sorting of acid hydrolases such as carboxypeptidase Y (CPY)...

clathrin-coated vesicle assembly. GGA2 has been shown to interact with RABEP1, Sortilin 1, BACE2 and CLINT1. GRCh38: Ensembl release 89: ENSG00000103365 – Ensembl...

et al. (January 2010). "WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway". Journal of the American Society of Nephrology...

(June 2011). "Sortilin: an unusual suspect in cholesterol metabolism: from GWAS identification to in vivo biochemical analyses, sortilin has been identified...

Recent research into co-receptors for p75, such as the sortilin co-receptor, has implicated sortilin in connection to neurotrophins, a type of nerve growth...

Patel AB, Tsilioni I, Leeman SE, Theoharides TC. Neurotensin stimulates sortilin and mTOR in human microglia. Proceedings of the National Academy of Sciences...

with the retromer, has been studied in various phagocytotic processes. Sortilin and the cation-independent mannose-6-phosphate receptor (CI-MPR) regulate...

Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, et al. (February 2004). "Sortilin is essential for proNGF-induced neuronal cell death". Nature. 427 (6977):...

Geuze HJ (2008). "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors". Traffic. 9 (3): 380–93. doi:10.1111/j...

Alzheimer Disease". Neurology. Rogaeva, E.; et al. (2007). "The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer's Disease"...

D, et al. (2008). "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors". Traffic. 9 (3): 380–93. doi:10.1111/j...

isoforms have been found for this gene. GGA1 has been shown to interact with Sortilin 1, BACE2, RABEP1 and ARF3. GRCh38: Ensembl release 89: ENSG00000100083...

interact with proteins present in Glut4 storage vesicles (GSVs), such as sortilin, LRP1 and Glut4 in adipocytes. Under inflammatory conditions its role in...