In coding theory, especially in telecommunications, a self-synchronizing code is a uniquely decodable code in which the symbol stream formed by a portion of one code word, or by the overlapped portion of any two adjacent code words, is not a valid code word.^[1] Put another way, a set of strings (called "code words") over an alphabet is called a self-synchronizing code if for each string obtained by concatenating two code words, the substring starting at the second symbol and ending at the second-last symbol does not contain any code word as substring. Every self-synchronizing code is a prefix code, but not all prefix codes are self-synchronizing.

Other terms for self-synchronizing code are synchronized code^[2] or, ambiguously, comma-free code.^[3] A self-synchronizing code permits the proper framing of transmitted code words provided that no uncorrected errors occur in the symbol stream; external synchronization is not required. Self-synchronizing codes also allow recovery from uncorrected errors in the stream; with most prefix codes, an uncorrected error in a single bit may propagate errors further in the stream and make the subsequent data corrupted.

Importance of self-synchronizing codes is not limited to data transmission. Self-synchronization also facilitates some cases of data recovery, for example of a digitally encoded text.

• UTF-8 is self-synchronizing because the leading byte (11xxxxxx) and subsequent bytes (10xxxxxx) of a multi-byte code point have different bit patterns.
• High Level Data Link Control (HDLC)
• Advanced Data Communication Control Procedures (ADCCP)
• Fibonacci coding

Counterexamples:

• The prefix code {00, 11} is not self-synchronizing; while 0, 1, 01 and 10 are not codes, 00 and 11 are.
• The prefix code {ab,ba} is not self-synchronizing because abab contains ba.
• The prefix code b^∗a (using the Kleene star) is not self-synchronizing (even though any new code word simply starts after a) because code word ba contains code word a.

• Bit slip
• Comma code
• Consistent overhead byte stuffing
• Dynkin sequence
• Kraus principle
• Kruskal's principle
• Overlapping instructions
• Pollard's lambda method
• Self-clocking signal
• Self-synchronizing block code

• "self-synchronizing code". Federal Standard 1037C: Telecommunications: Glossary of Telecommunication Terms. General Services Administration. 1996-08-06. Archived from the original on 2022-01-22.
• MIL-STD-188