SORBS3

SORBS3
Identifiers
AliasesSORBS3, SCAM-1, SCAM1, SH3D4, sorbin and SH3 domain containing 3
External IDsOMIM: 610795; MGI: 700013; GeneCards: SORBS3
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

10174

20410

Ensembl

ENSG00000120896

ENSMUSG00000022091

UniProt

O60504

Q9R1Z8

RefSeq (mRNA)

NM_001018003
NM_005775

NM_001271407
NM_001271408
NM_001271409
NM_011366

RefSeq (protein)

NP_001018003
NP_005766

NP_001258336
NP_001258337
NP_001258338
NP_035496

Location (UCSC)Chr 8: 22.54 – 22.58 MbChr 14: 70.42 – 70.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vinexin is a protein that in humans is encoded by the SORBS3 gene.[5][6][7]


Interactions

SORBS3 has been shown to interact with DLG5[8] and MAPK1.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120896 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022091 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kioka N, Sakata S, Kawauchi T, Amachi T, Akiyama SK, Okazaki K, Yaen C, Yamada KM, Aota S (Mar 1999). "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization". J Cell Biol. 144 (1): 59–69. doi:10.1083/jcb.144.1.59. PMC 2148117. PMID 9885244.
  6. ^ Kioka N (Jan 2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku. 74 (11): 1356–60. PMID 12510380.
  7. ^ "Entrez Gene: SORBS3 sorbin and SH3 domain containing 3".
  8. ^ Wakabayashi M, Ito Takuya, Mitsushima Masaru, Aizawa Sanae, Ueda Kazumitsu, Amachi Teruo, Kioka Noriyuki (Jun 2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. ISSN 0021-9258. PMID 12657639.
  9. ^ Mitsushima M, Suwa Akira, Amachi Teruo, Ueda Kazumitsu, Kioka Noriyuki (Aug 2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. 279 (33): 34570–7. doi:10.1074/jbc.M402304200. ISSN 0021-9258. PMID 15184391.

Further reading


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