SNAP29

SNAP29
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNAP29, CEDNIK, SNAP-29, synaptosome associated protein 29kDa, synaptosome associated protein 29
External IDsOMIM: 604202; MGI: 1914724; HomoloGene: 3512; GeneCards: SNAP29; OMA:SNAP29 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9342

67474

Ensembl

ENSG00000099940

ENSMUSG00000022765

UniProt

O95721

Q9ERB0

RefSeq (mRNA)

NM_004782

NM_023348

RefSeq (protein)

NP_004773

NP_075837

Location (UCSC)Chr 22: 20.86 – 20.89 MbChr 16: 17.22 – 17.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.[5][6][7]

Function

This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene.[7]

Interactions

SNAP29 has been shown to interact with Syntaxin 3[5] and EHD1.[8]

SNAP29 was shown to interact with CVB3 and EV-D68 viral protease 3C.[9][10][11]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099940 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022765 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, et al. (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–34179. doi:10.1074/jbc.273.51.34171. PMID 9852078.
  6. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  7. ^ a b "Entrez Gene: SNAP29 synaptosomal-associated protein, 29kDa".
  8. ^ Rotem-Yehudar R, Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". The Journal of Biological Chemistry. 276 (35): 33054–33060. doi:10.1074/jbc.M009913200. PMID 11423532.
  9. ^ Yasir Mohamud, Wikidata Q138763465
  10. ^ Mohamud Y, Shi J, Qu J, Poon T, Xue YC, Deng H, et al. (March 2018). "Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication". Cell Reports. 22 (12): 3292–3303. doi:10.1016/j.celrep.2018.02.090. PMID 29562184.
  11. ^ Corona AK, Saulsbery HM, Corona Velazquez AF, Jackson WT (March 2018). "Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit". Cell Reports. 22 (12): 3304–3314. doi:10.1016/j.celrep.2018.03.003. PMC 5894509. PMID 29562185.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: O95721 (Synaptosomal-associated protein 29) at the PDBe-KB.

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