SMG7

SMG7

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YA0

Identifiers

SMG7, C1orf16, EST1C, SGA56M, nonsense mediated mRNA decay factor, SMG7 nonsense mediated mRNA decay factor

External IDs

OMIM: 610964; MGI: 2682334; HomoloGene: 32235; GeneCards: SMG7; OMA:SMG7 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q25.3	Start	183,472,216 bp^[1]
Band	1q25.3	End	183,598,246 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 G3	Start	152,712,746 bp^[2]
Band	1\|1 G3	End	152,778,397 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

internal globus pallidus

tendon of biceps brachii

right uterine tube

right testis

left testis

islet of Langerhans

epithelium of colon

ganglionic eminence

postcentral gyrus

cerebellar cortex

Top expressed in

tail of embryo

genital tubercle

ascending aorta

aortic valve

zygote

blood

hand

cumulus cell

mesenteric lymph nodes

interventricular septum

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein phosphatase 2A binding protein binding telomeric DNA binding ribonuclease activity ribonucleoprotein complex binding telomerase RNA binding
Cellular component	cytoplasm intermediate filament cytoskeleton nucleus telomerase holoenzyme complex cytosol
Biological process	regulation of dephosphorylation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA export from nucleus telomere maintenance via telomerase regulation of RNA stability RNA phosphodiester bond hydrolysis regulation of telomere maintenance via telomerase
Sources:Amigo / QuickGO

Species

Human

Mouse


9887


226517


ENSG00000116698


ENSMUSG00000042772


Q92540


Q5RJH6

RefSeq (mRNA)

NM_001174061 NM_014837 NM_173156 NM_201568 NM_201569
NM_001331007 NM_001350219 NM_001350220 NM_001350221 NM_001350222 NM_001375584 NM_001375585


NM_001005507 NM_001160256 NM_001160257 NM_001359257

RefSeq (protein)

NP_001167532 NP_001317936 NP_775179 NP_963862 NP_963863
NP_001337148 NP_001337149 NP_001337150 NP_001337151 NP_001362513 NP_001362514


NP_001005507 NP_001153728 NP_001153729 NP_001346186

Location (UCSC)

Chr 1: 183.47 – 183.6 Mb

Chr 1: 152.71 – 152.78 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116698 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042772 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, et al. (November 2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Molecular Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.
^ Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E (February 2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Molecular Cell. 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
^ "Entrez Gene: SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)".
^ Yang L, Kraft VA, Pfeiffer S, Merl-Pham J, Bao X, An Y, et al. (June 2020). "Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1". Molecular Oncology. 14 (10): 2420–2435. doi:10.1002/1878-0261.12754. PMC 7530794. PMID 32602581.

Further reading

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, et al. (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
Reichenbach P, Höss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (April 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Current Biology. 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087. S2CID 14423276.
Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (April 2003). "Functional conservation of the telomerase protein Est1p in humans". Current Biology. 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629. S2CID 6685276.
Unterholzner L, Izaurralde E (November 2004). "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay". Molecular Cell. 16 (4): 587–96. doi:10.1016/j.molcel.2004.10.013. PMID 15546618.
Azzalin CM, Lingner J (February 2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Current Biology. 16 (4): 433–9. doi:10.1016/j.cub.2006.01.018. PMID 16488880. S2CID 17197870.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

v t e PDB gallery
1ya0: Crystal structure of the N-terminal domain of human SMG7

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