Polylaminin

Polylaminin or polyLM, is a stabilized form of laminin, a family of natural proteins, which is being studied for use in treating spinal cord injuries in animals and humans.[1][2][3] In early human trials, a patient with a fractured neck vertebra after a car accident had a full recovery after a year, and a chronic quadriplegic patient regained arm movement.[4][5][6] The Brazilian Academy of Neurology, Brazilian Academy of Sciences, and the Brazilian Society for the Progress of Science advise caution before clinical tests are completed.[7]

References

  1. ^ Marques, Jairo; Pasquini, Patrícia (9 November 2025). "Groundbreaking Brazilian Drug, Considered Capable of Reversing Spinal Cord Injury, Presented in São Paulo". Folha de S.Paulo. Retrieved 2 March 2026.
  2. ^ Menezes, Karla; Lima, Marco Aurelio B.; et al. (21 February 2024). "Return of Voluntary Motor Contraction After Complete Spinal Cord Injury: A Pilot Human Study on Polylaminin". medRxiv 10.1101/2024.02.19.24301010v1.
  3. ^ "Brazilian scientists use placenta protein to restore some movement in dogs and humans with spinal cord injuries".
  4. ^ de Carvalho, Ana Luiza (11 September 2025). "Cristália drug offers hope for quadriplegia patients". Valor International. Retrieved 2 March 2026.
  5. ^ National Cancer Institute (4 April 2023). "The case of polylaminin in the treatment of spinal cord injuries". YouTube. Retrieved 3 October 2025.
  6. ^ National Cancer Institute (30 October 2025). "Polylaminin: The Brazilian discovery that could transform the treatment of spinal cord injuries". YouTube. Retrieved 3 October 2025.
  7. ^ Collucci, Cláudia (24 February 2026). "Neurologists Warn of Lack of Evidence Regarding Polylaminin's Action in Spinal Cord Injury". Folha de S.Paulo. Retrieved 1 March 2026.
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