DOSEN PROFIL LENGKAP

Podocytes are cells in Bowman's capsule in the kidneys that wrap around capillaries of the glomerulus. Podocytes make up the epithelial lining of Bowman's...

histopathologic finding of scarring (sclerosis) of glomeruli and damage to renal podocytes. This process damages the filtration function of the kidney, resulting...

and repair in pathology affecting podocytes. Podocin may interact with nephrin to guide it onto lipid rafts in podocytes, requiring the integrity of an arginine...

physical contact with podocytes. There is two-way chemical cross talk among the mesangial cells, the capillaries, and the podocytes to fine-tune the glomerular...

composed of a visceral inner layer formed by specialized cells called podocytes, and a parietal outer layer composed of simple squamous epithelium. Fluids...

brain. In the kidneys specialised cells called podocytes extend processes that terminate in podocyte foot processes that cover capillaries in the nephron...

the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood...

the fused basal lamina of endothelial cells and podocytes, and the filtration slits of the podocytes. This barrier permits passage of water, ions, and...

blood. Inflammation that affects the cells surrounding the glomerulus, podocytes, increases the permeability to proteins, resulting in an increase in excreted...

calcineurin-mediated dephosphorylation of synaptopodin, a regulator of Rho GTPases in podocytes, thereby preserving the phosphorylation-dependent synaptopodin-14-3-3...

fused basal lamina of the endothelial cells and podocytes, and the filtration slits of the podocytes. The barrier permits the passage of water, ions,...

Galveston and CEO of the UTMB Health System. Reiser's research focuses on podocyte biology and glomerular diseases. His laboratory has been developing therapies...

thought to modify the glomerular basement membrane, specifically the podocytes, increasing permeability. This allows the leakage of albumin and other...

normal mature kidneys, dendrin is found only in the podocytes near the slit diaphragm. Podocytes are epithelia cells in the kidneys that do not readily...

glomerular basement membrane and the occurrence of small pores in the podocytes of the glomerulus. These pores become large enough to permit both proteins...

later onset remains challenging. 2011 studies have shown that looking for podocytes (specialized cells of the kidney) in the urine has the potential to aid...

clinicopathologic entity that involves hypertrophy and hyperplasia of podocytes and segmentar or global collapse of the glomerulus. Glomerulocystic kidney...

refer to cervical effacement. It can also refer to a process occurring in podocytes in nephrotic syndrome. In histopathology, it refers to the near obliteration...

related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes". Blood. 115 (18): 3756–62. doi:10.1182/blood-2009-11-251132. PMC 2890576...

cell types include: Kidney glomerulus parietal cell Kidney glomerulus podocyte Intraglomerular mesangial cell Extraglomerular mesangial cell Juxtaglomerular...

membrane, and podocyte processes. The resulting fluid is then filtered further throughout the various tubular segments to become urine. Podocytes are a particularly...

cells and macrophages are the primary cells infected by hantaviruses. Podocytes, tubular cells, dendritic cells, and lymphocytes can also be infected...

It is faced by a cell layer on either side, the endothelium, and the podocytes, and has a thicker structure of three laminae. It is thicker by the fusion...

sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes in the glomerulus (Bowman's capsule) in the kidneys. It is a member of...

When podocytes are stretched by glomerular capillary pressure, mechanosensitive TRPC6 channels trigger a surge in Ca2+ influx into podocytes, causing...

Syndrome, and hepatitis B, and some cancers, including multiple myeloma. Podocytes are specialized cells that make up parts of the lining of the glomerulus...

lead to a separation through a semipermeable membrane (provided by the podocytes). The Bowman's capsule contains a dense capillary network called the glomerulus...

to the podocyte within the glomerulus of the kidney. This circulating factor damages the podocyte, which changes its structure. The podocytes are now...

Podocin is a protein component of the filtration slits of podocytes. Glomerular capillary endothelial cells, the glomerular basement membrane and the...

form a glomerular functional unit with glomerular endothelial cells and podocytes through interactions of molecular signalling pathways which are essential...

protein to diffuse. In the renal glomerulus the capillaries are wrapped in podocyte foot processes or pedicels, which have slit pores with a function analogous...

vitro model glomerulus with differentiation of stem cells into mature podocytes. She was honored for her interdisciplinary work in this project by a Physics...

known as a nephridiopore. The pouch is occupied by special cells called podocytes, which facilitate ultrafiltration of the blood through the partition between...

I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group...

Gene therapy has been frequently discussed, but delivering it to the podocytes in the glomerulus that normally produce the type IV collagen in the glomerular...

and other dissolved wastes. However, brachiopods have no sign of the podocytes, which perform the first phase of excretion in this process, and brachiopod...

cell Mesangial cell Parietal epithelial cell Urinary system Barrier cells Podocyte Proximal tubule brush border cell Loop of Henle thin segment cell Kidney...

cells and macrophages are the primary cells infected by hantaviruses. Podocytes, tubular cells, dendritic cells, and lymphocytes can also be infected...

causing stress on the endothelial cells, the mesangial cells and the podocytes. This exacerbates the dysfunction caused by the metabolic effects of hyperglycemia...

composed of four cell types: fenestrated endothelium, mesangial cells, podocytes and parietal epithelial cells of Bowman's capsule. At least 16 different...

Aström E, et al. (2003). "A novel protein, densin, expressed by glomerular podocytes". J. Am. Soc. Nephrol. 14 (7): 1731–7. doi:10.1097/01.ASN.0000075553.33781...

focal segmental glomerulosclerosis developed junctional defects between podocytes, the filtering cells affected in that disease. Importantly, these disease...

Podocalyxin is another sialoglycoprotein found in the foot processes of the podocyte cells of the glomerulus in kidneys. Podocalyxin is negatively charged and...

cells and macrophages are the primary cells infected by hantaviruses. Podocytes, tubular cells, dendritic cells, and lymphocytes can also be infected...

various tissues including the endothelium, intestinal epithelium, kidney podocytes, and antigen-presenting cells, where it continues to regulate IgG and...

junctional defects between podocytes, the filtering cells affected in that disease. This was traced to the inability of podocytes to form microvilli between...

caused by AGEs and the other pathways, causes apoptosis of pericytes and podocytes in the retina and the kidneys respectively leading to capillary wall fragility...

Wesley S. Ercanbrack; Rebecca A. Wingert (20 February 2023). "Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish". Journal of Developmental...

Aguillon-Prada R, Jauregui AN, et al. (June 2011). "Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis". Science Translational...

guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". Journal of the American Society of Nephrology. 12 (4): 667–77. doi:10...

expansion with no mesangial hypercellularity, hypertrophy of the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the...

between podocytes and endothelial cells in a coculture system, and further highlighted that segmental glomerulosclerosis develops as a result of podocyte-endothelial...

syndrome): This gene encodes for the protein laminin β2, which helps attach podocytes to the glomerular basement membrane. Patients with Pierson syndrome have...

actin binding protein synaptopodin (which was originally described in podocytes of the kidney) is an essential component of the SA. Mice that lack the...

associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM] SYNPO has been shown to interact...

component of glomerular podocytes. Inactivation of the encoding gene in mice leads to anuria, omphalocele and perinatal death. Podocytes are highly differentiated...

of parietal epithelial cells from Bowman's capsule and in some cases podocytes. Serum analysis often aids in the diagnosis of a specific underlying disease...

microcystic tubular dilatation that is highly echogenic, and prominent podocytes. The characteristic feature of collapsing glomerulopathy is collapse of...

mediated immune responses. As a result of the calcineurin inhibition, podocytes (cells within the kidneys) are stabilized while inflammation is reduced...

signal pathway regulates microtubule-based process formation of cultured podocytes--inhibition of ROCK promoted process elongation". Nephron Experimental...

blood's volume in cm3 per gm of body weight is twice that of a human. Podocytes on the walls of the blood vessels perform first-stage filtration of soluble...

differentiation, BASP1 is mostly found within podocytes, which regulate kidney filtration of the blood in the glomerulus. Podocytes also continue to express WT1 in...

expression in podocytes was seen in PHN, the rat model of human mGN. This UCH-L1 expression is thought to induce at least in part podocyte hypertrophy....

immunoreactivity of glial fibrillary acidic protein in mesangial cells and podocytes of the glomeruli of rat kidney in vivo and in culture". Biology of the...

liver. Pancreatic stellate cell, reside in exocrine areas of the pancreas Podocyte, found in the Bowman's capsule in the kidneys Osteocyte, commonly found...

2006). "Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy". Diabetes. 55 (1):...

et al. (March 2011). "Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane"...

Peti-Peterdi J, et al. (12 December 2013). "A novel source of cultured podocytes". PLOS ONE. 8 (12) e81812. Bibcode:2013PLoSO...881812D. doi:10.1371/journal...

"Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol...

cells, composed by the endothelium, basement membrane and the epithelial podocytes. The fluid that is filtered from the capillary blood into Bowman's space...

T, Oguchi H, et al. (October 2015). "Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria". Kidney...

inhibits bone fracture healing in mice. In the kidney, CCN1 is expressed in podocytes in normal adult and embryonic glomeruli, but expression is decreased in...

complications. It is highly expressed in diabetic blood vessels, cardiomyocytes, podocytes, and immune cells, where it co-localizes with ligands such as AGEs, S100...

A5-stained EVs, etc.); or c) descriptions of conditions or cell of origin (podocyte EVs, hypoxic EVs, large oncosomes, apoptotic bodies)." The terms "ectosome...

"Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis". Human Pathology...

(NPHS2; MIM 604766). NEPH1 is expressed in filtration slits of kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration...

transmembrane glycoprotein that is expressed under normal conditions in kidney podocytes, type 1 alveolar cells, skeletal muscle cells, placenta, etc. Podoplanin...

Investigation". www.the-asci.org. "Young Investigator Attains Recognition for Podocyte Research - Kidney News". www.kidneynews.org. "Prof. Dr. Tobias B. Huber...

"Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American...

Interstitial cell of Cajal Spleen See main article on Intermediate mesoderm. Podocyte Angioblast → Endothelial cell Mesangial cell Intraglomerular Extraglomerular...

required for parasite killing. Within the kidney, ApoL1 is found in the podocytes in the glomeruli, the proximal tubular epithelium and the arteriolar endothelium...

junctions. Since then, Farquhar has continued to study junctions in the podocytes. After leaving Rockefeller in 1962, she established her own laboratory...

24106 Cybulsky, Papillon. “Ste20-Like Kinase, SLK, a Novel Mediator of Podocyte Integrity.” American Journal of Physiology. Renal Physiology, vol. 315...

glomerular basement membrane is a special case, consisting of a fusion of the podocyte and endothelial basal laminas, and lacking a lamina reticularis. Thus,...

diseases and differentiation contexts. It is upregulated in redifferentiated podocytes derived from amniotic kidney progenitor cells, a finding that may indicate...

"Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American...

endothelial cells, but was also found in other cell types, such as platelets, podocytes in the kidney and several brain cells. The only known role of the ADAMTS13...

smooth muscle cells, osteoclasts, osteoblasts, goblet cells, and kidney podocytes as well as activate the heme oxygenase system of cells thereby increasing...

Pod-1 expression in mesenchymal cells and podocytes, with expression coinciding with the onset of podocyte differentiation. It was found that expression...

"Insight into podocyte differentiation from the study of human genetic disease: nail-patella syndrome and transcriptional regulation in podocytes". Pediatr...

S, Lehtonen E, Hyvönen ME, Ristola M, Fogarty CL, et al. (May 2015). "Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway". Cell...

during early development of the kidneys, including differentiation of podocytes and maturation of the glomerular basement membrane. It is also involved...

guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". Journal of the American Society of Nephrology. 12 (4): 667–77. doi:10...

in mtDNA maintenance. MPV17 seems to be also involved in apoptosis in podocytes, and involved in ROS. The human MPV17 gene is located on chromosome 2...

basement membrane seems to be the cause of the thickening. Also, the podocytes lose their foot processes. As the disease progresses, the deposits will...

hepatocytes; 7) multinucleated osteoclasts in bone tissues; 8) kidney podocytes; and 9) cells in the nervous system, e.g., microglia cells in the brain's...

Basgen, John M; Sinha, Satyesh (2011). "Using stereologic techniques for podocyte counting in the mouse: shifting the paradigm". Am J Nephrol. 33 (Suppl...

the proximal tubule. LRP2 is also expressed in podocytes, and antigenic response to LRP2 in podocytes is the primary cause of Heymann nephritis in rats...

CLIC5A is expressed chiefly in the renal glomerulus, specifically in podocytes. Within the cell, CLIC5A is localized to the plasma membrane and the cytosol...

Gunn-Moore FJ, Prystowsky MB, Dholakia K (February 2016). "Visualization of podocyte substructure with structured illumination microscopy (SIM): a new approach...

glomeruli and spontaneously differentiate into cells expressing markers of podocytes (podocin; ~31%), mesangial cells (megsin; ~13%), and endothelial cells...

internal organs. Additional studies indicate a resemblance to vertebrate podocytes, as vascular fluid within the ligamentum denticulatum may travel into...

alveolar cells of the lung and kidney podocytes (podoplanin was given its name based on its expression in podocytes); b) endothelial cells lining the lymphatic...

Differential FAM63B expression between amniotic fluid kidney-progenitor podocytes and differentiated podocytes....

Renal corpuscle Glomerulus Bowman's capsule Glomerular basement membrane Podocyte Filtration slits Mesangium Intraglomerular mesangial cell Renal tubule...

that in recent years has made significant contributions to the study of podocytes and glomerular endothelial cells, interactions between them and factors...

et al. (May 2025). "Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies". Kidney International. 107 (5):...

(2024-05-01). "C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis". Molecular Therapy. 32 (5): 1540–1560. doi:10...

The following is a partial list of the "A" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)...

protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular...

kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1". American Journal of Physiology. Renal Physiology. 299 (5): F965-72...

examine the fate of the thorium tracers. This led him to examine glomerular podocytes and capsular epithelial cells. He became interested in Bence Jones proteinuria...

pass through the glomerular basement membrane and slit membranes between podocytes to become tr-DNA. The exact mechanism of the passage of cfDNA is yet to...

reactive oxygen species. This induces widening of inter-podocyte radii and lowers the number of podocytes which increases the amount of albumin that is filtered...

biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli". J. Am. Soc. Nephrol. 14 (6): 1452–63. doi:10.1097/01...

400– glomerular basement membrane Mesh A05.810.453.324.359.372.650 - podocytes MeSH A05.810.453.324.359.520 – juxtaglomerular apparatus MeSH A05.810...

most of the cells that form the kidneys, including collecting ducts, podocytes, vasculature cells, nephrons and loops of Henle, and are closely related...

2010). "Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis". J. Biol. Chem. 285 (33): 25677–85...

embryonically lethal but pups die within 48-hours due to the abnormal fusion of podocyte foot processes within the kidney. These Fat1 knockout mice also showed...

"Nephrin is specifically located at the slit diaphragm of glomerular podocytes". Proceedings of the National Academy of Sciences. 96 (14): 7962–7967...

"Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American...

APOL1 is found in vascular endothelium, liver, heart, lung, placenta, podocytes, proximal tubules, and arterial cells. The protein as a secreted form...

PMID 12871946. Rastaldi MP, Armelloni S, Berra S, et al. (2003). "Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector...

induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic...

PMID 12168954. Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol...

PMID 28018168. Xia L, Zhou M, Kalhorn TF, Ho HT, Wang J (June 2009). "Podocyte-specific expression of organic cation transporter PMAT: implication in...

lung parenchyma of smokers. Nox2 has been shown to interact directly with podocyte TRPC6 channels. GRCh38: Ensembl release 89: ENSG00000165168 – Ensembl,...

disease, e.g., they reduce proteinuria, stabilize the cytoskeleton of the podocyte cells in the kidneys' Bowman's capsule, constrict the kidneys' afferent...

kidneys, but damage to the epithelial glomerular tissue and the endothelial podocytes are common in diabetic nephropathy. This damage affects the kidneys' ability...

Galloway–Mowat syndrome is yet to be discovered. However, mutations in podocyte proteins, such as nephrin, alpha-actinin 4, and podocin, are associated...

glomerular injury, which includes increased urine podocyte excretion in TG and significant podocyte detachment, both of which are linked to progressive...

suppression of the TGF-β pathway. Dach1 is highly expressed in the adult podocyte, with transcripts showing an approximate tenfold enrichment compared to...

tubular basement thickening, mesangial expansion, glomerulosclerosis, podocyte effacement and nephron loss. DKD occurs in 30%-50% of the diabetic patient...

Zhuang SG, Yu XY, et al. (January 2024). "Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin...

(minimal mesangial) LM: normal glomeruli IF: purely mesangial deposits EM: podocyte foot process effacement Class II (proliferative mesangial) IF: strict mesangial...

Canaud, Guillaume; et al. (October 2013). "AKT2 is essential to maintain podocyte viability and function during chronic kidney disease". Nature Medicine...

PMID 16952470. Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol...

Takagi M, Horikoshi S, Tomino Y (July 2011). "Mindin: a novel marker for podocyte injury in diabetic nephropathy". Nephrology, Dialysis, Transplantation...

LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning...

Tryggvason K, Yan K (July 2009). "Amino acid transporter LAT3 is required for podocyte development and function". Journal of the American Society of Nephrology...

; Lescuyer, Pierre; Moll, Solange (2013-04-26). "Proteomic analysis of podocyte exosome-enriched fraction from normal human urine". Journal of Proteomics...

Kanwar YS, Avila-Casado C, Chugh SS (December 2006). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". The Journal...

Nephrin, Podocin, and the Actin Cytoskeleton : Evidence for a Role in Podocyte Foot Process Formation". Am. J. Pathol. 161 (4): 1459–66. doi:10...