Plague or The Plague may refer to:

• Plague (disease), (commonly referred to as bubonic plague or black death), caused by infectious bacteria Yersinia pestis
• An epidemic of infectious disease (medical or agricultural)
• A pandemic caused by such a disease
• A swarm of pest insects such as locusts
  • A massive attack of other pests afflicting agriculture
  • Overpopulation in wild animals afflicting the environment and/or agriculture
• Plague, collective noun for common grackles

• List of epidemics
• Antonine Plague, an ancient pandemic in 165–189 CE brought to the Roman Empire by troops returning from campaigns in the Near East
• Black Death, the Eurasian pandemic beginning in the 14th century, also known as "The Plague"
• Great Northern War plague outbreak, a European outbreak in the early 18th century
• Great Plague of London, a massive outbreak in England that killed an estimated 20% of London's population in 1665–1666
• Plague of Athens, a devastating epidemic which hit Athens in ancient Greece in 430 BCE
• Plague of Justinian, a pandemic in 541–542 CE in the Byzantine Empire
• Plague Riot, a riot in Moscow in 1771 caused by an outbreak of bubonic plague

• Third plague pandemic or Third Plague, a major plague pandemic that began in China in 1855 until 1960
  • Manchurian plague (1910–11): Part of the third plague pandemic
• HIV/AIDS, originally referred to as the "gay plague" when it was discovered in the 1980s (see History of HIV/AIDS)
• Vole plague in Castile and León (Spain), in 2007.

• Plague (painting), by Arnold Böcklin

• Plague, Lisbeth Salander's hacker friend and colleague in the Hacker Republic, e.g., see The Girl who Kicked the Hornet's Nest#Trial
• The Plague (G.I. Joe), a Cobra special forces team in the comic book G.I. Joe: America's Elite
• The Plague, a duo of demonic assassins in the movie Hobo with a Shotgun

• Plague (1979 film), a science-fiction film
• The Plague (1992 film), a drama film
• The Plague (2006 film), a horror film
• Plague (2014 film), an Australian horror film
• The Plague (2025 film), a psychological drama thriller film

• Corrupted Blood incident, a virtual plague that occurred in the video game World of Warcraft
• Plague Inc., a strategy game for smartphones and tablets by Ndemic Creations
• Plague!, a card game about the Black Plague in England
• Plague of Shadows (Plague Knight), a character and DLC gamemode for Shovel Knight
• The Plague, a playable killer character of Babylonian origin from the asymmetrical-survival horror Dead by Daylight
• "A Plague Tale: Innocence" and "A Plague Tale: Requiem", survival horror games set in 14th century France

• Plague, a 2000 young adult novel by Malcolm Rose
• Plague, a 1977 thriller novel by Graham Masterton
• Plague 99, a novel by Jean Ure
• The Plague (novel), a novel by Albert Camus
• "The Plague" (Dragon Prince), an epidemic which affects both humans and dragons in Melanie Rawn's novel
• The Plague (magazine), New York University's comedy magazine

• The Plague (American band), a hardcore punk band from Cleveland
• The Plague (British band), a punk rock band
• The Plague (New Zealand band), a theatrical punk/art rock band

• Plague (Klinik album)
• Plagues (album), by The Devil Wears Prada
• The Plague, by Demon
• The Plague (Brotha Lynch Hung album)

• The Plague (Nuclear Assault EP)
• The Plague (I Hate Sally EP)

• "Plague" (song), by Crystal Castles from the 2012 album III
• "The Plague", by Demon from the 1983 album by the same name
• "The Plague," an unreleased song by The Mountain Goats that appears on the 2020 live album The Jordan Lake Sessions
• "THE PLAGUE," a song by Melanie Martinez

• Plague! The Musical, by David Massingham and Matthew Townend

• "Plague" (The Dead Zone), a 2003 episode
• "Plague" (Deadwood), a 2004 episode
• "The Plague" (Diagnosis: Murder), a 1994 episode
• "The Plague" (Doctor Who), second episode of the 1966 serial The Ark
• "Plague" (Domina), a 2021 episode
• "The Plague" (Father Ted), a 1996 episode
• The Plague, English title of 2018 Spanish TV series La peste

• Plagues of Egypt, the 10 calamities that God inflicted on Egypt in the book of Exodus
• The seven plagues poured out from seven bowls in Revelation 15:5-16:21

• Capacitor plague, a condition afflicting computer motherboards in which capacitors fail

• Plaque (disambiguation)