Ord's thyroiditis

Ord's disease
SpecialtyEndocrinology Edit this on Wikidata

Ord's thyroiditis is an atrophic form of chronic thyroiditis, an autoimmune disease where the body's own antibodies fight the cells of the thyroid.

It is named after the physician, William Miller Ord, who first described it in 1877 and again in 1888. It is more common among women than men. It has historically been separated from Hashimoto's Thyroiditis which presents with goiters, however some argue they each represent extremes of the same disease and should be classified together as a combined "Ord-Hashimoto’s disease".[1]

Signs and symptoms

The first sign of Ord's thyroiditis is the atrophy of the thyroid gland from the start this can be identified by ultrasound.[2] Another sign to help identify this disease is the presence of blocking anti-TSH receptors. Ord's thyroiditis can share symptoms with functional hypothyroidism.[3]

Pathophysiology

Physiologically, antibodies to thyroid peroxidase and/or thyroglobulin cause gradual destruction of follicles in the thyroid gland. Accordingly, the disease can be detected clinically by looking for these antibodies in the blood. It is also characterized by invasion of the thyroid tissue by leukocytes, chiefly T-lymphocytes.[2]

Ord's thyroiditis usually results in hypothyroidism. Transient hyperthyroid states in the acute phase, (a common observation in Hashimoto's thyroiditis), are rare in Ord's disease.[citation needed]

Diagnosis

Ord's thyroiditis can be difficult to identify as its signs can be easy to miss or share symptoms with other diseases. One way to identify Ord's Thyroiditis is by checking for an atrophied thyroid gland as this is the main symptom of the diseases. Checking for functional hypothyroidism can help identify if atrophic thyroiditis is present as functional hypothyroidism is associated with and can be caused by Ord's Thyroiditis.[4]

Treatment

Treatment is as with hypothyroidism, daily thyroxine(T4).

[5]

Epidemiology

Outside Europe a goitrous form of autoimmune thyroiditis (Hashimoto's Thyroiditis) is more common than Ord's disease.[citation needed]

See also

References

  1. ^ Carlé, Allan; Pedersen, Inge Bülow; Knudsen, Nils; Perrild, Hans; Ovesen, Lars; Jørgensen, Torben; Laurberg, Peter (1 March 2009). "Thyroid Volume in Hypothyroidism due to Autoimmune Disease Follows a Unimodal Distribution: Evidence against Primary Thyroid Atrophy and Autoimmune Thyroiditis Being Distinct Diseases". The Journal of Clinical Endocrinology & Metabolism. 94 (3): 833–839. doi:10.1210/jc.2008-1370. eISSN 1945-7197. ISSN 0021-972X. PMID 19088156. S2CID 8184654.
  2. ^ a b Stojković, Mirjana (2022). "Thyroid function disorders". Arhiv za farmaciju. 72 (5): 429–443. doi:10.5937/arhfarm72-39952. ISSN 0004-1963.
  3. ^ Jara, Luis J.; Vera-Lastra, Olga; Medina, Gabriela (2008), Shoenfeld, Yehuda; Cervera, Ricard; Gershwin, M. Eric (eds.), "Atrophic Thyroiditis", Diagnostic Criteria in Autoimmune Diseases, Totowa, NJ: Humana Press, pp. 221–225, doi:10.1007/978-1-60327-285-8_42, ISBN 978-1-60327-427-2, retrieved 2024-03-09{{citation}}: CS1 maint: work parameter with ISBN (link)
  4. ^ Jara, Luis J.; Vera-Lastra, Olga; Medina, Gabriela (2008), Shoenfeld, Yehuda; Cervera, Ricard; Gershwin, M. Eric (eds.), "Atrophic Thyroiditis", Diagnostic Criteria in Autoimmune Diseases, Totowa, NJ: Humana Press, pp. 221–225, doi:10.1007/978-1-60327-285-8_42, ISBN 978-1-60327-427-2, retrieved 2024-03-09{{citation}}: CS1 maint: work parameter with ISBN (link)
  5. ^ Jara, Luis J.; Vera-Lastra, Olga; Medina, Gabriela (2008), Shoenfeld, Yehuda; Cervera, Ricard; Gershwin, M. Eric (eds.), "Atrophic Thyroiditis", Diagnostic Criteria in Autoimmune Diseases, Totowa, NJ: Humana Press, pp. 221–225, doi:10.1007/978-1-60327-285-8_42, ISBN 978-1-60327-427-2, retrieved 2024-03-09{{citation}}: CS1 maint: work parameter with ISBN (link)

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.