OSTbeta

SLC51B
Identifiers
AliasesSLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit, solute carrier family 51 subunit beta, PBAM2
External IDsOMIM: 612085; MGI: 3582052; HomoloGene: 18721; GeneCards: SLC51B; OMA:SLC51B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

123264

330962

Ensembl

ENSG00000186198

ENSMUSG00000053862

UniProt

Q86UW2

Q80WK2

RefSeq (mRNA)

NM_178859

NM_178933

RefSeq (protein)

NP_849190

NP_849264

Location (UCSC)Chr 15: 65.05 – 65.05 MbChr 9: 65.32 – 65.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.[5][6]

Function

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[6][7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[7] The heterodimer furthermore is essential for intestinal bile acid transport.[8]

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186198 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053862 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: OSTbeta organic solute transporter beta".
  6. ^ a b c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.
  7. ^ a b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450.
  8. ^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. Bibcode:2008PNAS..105.3891R. doi:10.1073/pnas.0712328105. PMC 2268840. PMID 18292224.

Further reading


Stub icon

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.