Microelectrode

This article is about the use of microelectrodes in electrophysiology. For applications in electroanalytical chemistry, see Ultramicroelectrode.

A microelectrode is an electrode used in electrophysiology either for recording neural signals or for the electrical stimulation of nervous tissue.[1][2] They were first developed by Ida Hyde in 1921.[3] Pulled glass pipettes with tip diameters of 0.5 μm or less are usually filled with 3 molars potassium chloride solution as the electrical conductor. When the tip penetrates a cell membrane the lipids in the membrane seal onto the glass, providing an excellent electrical connection between the tip and the interior of the cell, which is apparent because the microelectrode becomes electrically negative compared to the extracellular solution. There are also microelectrodes made with insulated metal wires, made from inert metals with high Young modulus such as tungsten, stainless steel, or platinum-iridium alloy[4] and coated with glass or polymer insulator with exposed conductive tips. These are mostly used for recording from the external side of the cell membrane.

See also

References

  1. ^ Kita, Justin M; Wightman, R Mark (October 2008). "Microelectrodes for studying neurobiology". Current Opinion in Chemical Biology. 12 (5): 491–496. doi:10.1016/j.cbpa.2008.06.035. PMC 2642896. PMID 18675377.
  2. ^ "Electroanalytical techniques in biosciences: conductometry, coulometry, voltammetry, and electrochemical sensors", Analytical Techniques in Biosciences, Academic Press, pp. 157–178, 2022-01-01, doi:10.1016/B978-0-12-822654-4.00004-X, retrieved 2026-03-13
  3. ^ Johnson, Elsie (1981). "Ida Henrietta Hyde: Early Experiments" (PDF). Physiologist. 24 (6): 1–2. PMID 7043502. Archived from the original (PDF) on 2011-05-23. Retrieved 2009-04-26.
  4. ^ Cogan, Stuart F. (August 2008). "Neural Stimulation and Recording Electrodes" (PDF). Annual Review of Biomedical Engineering. 10 (1): 275–309. doi:10.1146/annurev.bioeng.10.061807.160518. PMID 18429704. S2CID 25087051. Archived from the original (PDF) on 2019-02-20.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.