Map44

mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Identifiers
SymbolMASP1
Alt. symbolsCRARF, PRSS5
NCBI gene5648
HGNC6901
OMIM600521
RefSeqNM_001879
UniProtP48740
Other data
LocusChr. 3 q27-q28
Search for
StructuresSwiss-model
DomainsInterPro

Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 [1]

See also

References

  1. ^ Degn SE, Hansen AG, Steffensen R, Jacobsen C, Jensenius JC, Thiel S (December 2009). "MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation". Journal of Immunology. 183 (11): 7371–8. doi:10.4049/jimmunol.0902388. PMID 19917686.
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