MES207

MES207
Identifiers
  • 4-anilino-1-benzyl-N-[2-(diaminomethylideneamino)ethyl]piperidine-4-carboxamide
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
Chemical and physical data
FormulaC22H30N6O
Molar mass394.523 g·mol−1
3D model (JSmol)
  • C1CN(CCC1(C(=O)NCCN=C(N)N)NC2=CC=CC=C2)CC3=CC=CC=C3
  • InChI=1S/C22H30N6O/c23-21(24)26-14-13-25-20(29)22(27-19-9-5-2-6-10-19)11-15-28(16-12-22)17-18-7-3-1-4-8-18/h1-10,27H,11-17H2,(H,25,29)(H4,23,24,26)
  • Key:SCPYAGLHLAAYFP-UHFFFAOYSA-N

MES207 is a drug used in scientific research which acts as a potent and selective antagonist for the neuropeptide FF receptor NPFF1, with 17x selectivity over the closely related receptor NPFF2. It prevented opioid-induced hyperalgesia in animal models.[1][2]

References

  1. ^ Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, et al. (November 2014). "Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors". Journal of Medicinal Chemistry. 57 (21): 8903–8927. doi:10.1021/jm500989n. PMC 4234442. PMID 25268943.
  2. ^ King TI, Roewekamp AC, Sharma A, Harrison S, Mesangeau C, Mottinelli M, et al. (December 2019). "Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1134–1135 121875. doi:10.1016/j.jchromb.2019.121875. PMC 7027589. PMID 31790916.
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