DOSEN PROFIL LENGKAP

LRCH4
Identifiers
Aliases	LRCH4, LRN, LRRN1, LRRN4, PP14183, leucine-rich repeats and calponin homology (CH) domain containing 4, leucine rich repeats and calponin homology domain containing 4
External IDs	MGI: 1917193; HomoloGene: 20532; GeneCards: LRCH4; OMA:LRCH4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,586,129 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,639,361 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right testis; ; left testis; ; blood; ; spleen; ; pituitary gland; ; monocyte; ; right ovary; ; left ovary; ; anterior pituitary;
	Top expressed in
	granulocyte; ; secondary oocyte; ; zygote; ; primary oocyte; ; thymus; ; spleen; ; testicle; ; bone marrow; ; genital tubercle; ; tail of embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	PML body; cytoplasm; basolateral plasma membrane;
Biological process	nervous system development; signal transduction; maintenance of epithelial cell apical/basal polarity;
	Sources:Amigo / QuickGO
Orthologs
	4034
	231798
	ENSG00000077454
	ENSMUSG00000093445
	O75427
	Q921G6
	NM_002319; NM_001289934
	NM_001168652; NM_146164
	NP_001276863; NP_002310
	NP_001162123; NP_666276
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene.^[5]^[6]

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077454 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000093445 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
^ ^a ^b "Entrez Gene: LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Shiio Y, Rose DW, Aur R, et al. (2006). "Identification and Characterization of SAP25, a Novel Component of the mSin3 Corepressor Complex". Mol. Cell. Biol. 26 (4): 1386–97. doi:10.1128/MCB.26.4.1386-1397.2006. PMC 1367179. PMID 16449650.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077454 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000093445 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799793-5] Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.

[entrez-6] "Entrez Gene: LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4".

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DOSEN PROFIL LENGKAP

LRCH4

References

Further reading

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