HNRNPLL

HNRNPLL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like
External IDsOMIM: 611208; MGI: 1919942; HomoloGene: 26701; GeneCards: HNRNPLL; OMA:HNRNPLL - orthologs
Orthologs
SpeciesHumanMouse
Entrez

92906

72692

Ensembl

ENSG00000143889

ENSMUSG00000024095

UniProt

Q8WVV9

Q921F4

RefSeq (mRNA)

NM_001142650
NM_138394

NM_144802

RefSeq (protein)

NP_001136122
NP_612403

NP_659051

Location (UCSC)Chr 2: 38.56 – 38.6 MbChr 17: 80.34 – 80.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.[5]

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143889 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024095 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like".
  6. ^ Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A (August 2008). "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–91. Bibcode:2008Sci...321..686O. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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