HECT domain

HECT-domain (ubiquitin-transferase)
structure of an e6ap-ubch7 complex: insights into the ubiquitination pathway
Identifiers
SymbolHECT
PfamPF00632
InterProIPR000569
SCOP21d5f / SCOPe / SUPFAM
Available protein structures:
PDB  IPR000569 PF00632 (ECOD; PDBsum)  
AlphaFold

In molecular biology, the HECT domain is a protein domain found in ubiquitin-protein ligases. The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus'.[1] Proteins containing this domain at the C terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thioester formation. Human thyroid receptor interacting protein 12 (TRIP12), which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human E6AP ubiquitin-protein ligase interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the p53 tumour-suppressor protein for ubiquitin-mediated proteolysis.

References

  1. ^ Huibregtse JM, Scheffner M, Beaudenon S, Howley PM (March 1995). "A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2563–7. Bibcode:1995PNAS...92.2563H. doi:10.1073/pnas.92.7.2563. PMC 42258. PMID 7708685.
This article incorporates text from the public domain Pfam and InterPro: IPR000569

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