DOSEN PROFIL LENGKAP

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene. Histones play a critical role in transcriptional regulation, cell cycle...

of 240 nM, 120 nM, and 155 nM, whereas it did not inhibit the class II HDAC5 or HDAC6 (IC50 = >80,000 nM). Potential actions against other HDACs, such...

compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5". Science Advances. 3 (11) e1701682. Bibcode:2017SciA....3E1682G. doi:10...

histone deacetylase, HDAC5 since it was known to have activity-dependent regulation in neurons. In fact, they found that HDAC5 was a central regulator...

signaling, which, in addition to phosphorylating CREB, also phosphorylates HDAC5. Figure 2: Psychostimulant-induced signaling events Broussard JI (January...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

signaling, which, in addition to phosphorylating CREB, also phosphorylates HDAC5. Figure 2: Psychostimulant-induced signaling events Broussard JI (January...

signaling, which, in addition to phosphorylating CREB, also phosphorylates HDAC5. Figure 2: Psychostimulant-induced signaling events Broussard JI (January...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

signaling, which, in addition to phosphorylating CREB, also phosphorylates HDAC5. Figure 2: Psychostimulant-induced signaling events Broussard JI (January...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

the hippocampal BDNF promoter, and also reduced expression of hippocampal HDAC5. Imipramine has a varied absolute oral bioavailability ranging from 22%...

concentration (μM) HDAC1 3.94–35.5 HDAC2 59.3 HDAC3 218.5 HDAC4 >15,000 HDAC5 >15,000 HDAC6 >20,000 HDAC7 >15,000 HDAC8 1.59–97.1 HDAC9 >15,000 HDAC10...

HDAC8 and no significant inhibition of other HDACs including HDAC3, HDAC4, HDAC5, HDAC9, HDAC10, and HDAC11. The drug produces anti-inflammatory effects...

inhibition of HDAC8 and no inhibition of several other HDACs, including HDAC4, HDAC5, HDAC6, and HDAC7. RGFP136 has been found to enhance long-term memory in...

inhibitory concentration (nM) HDAC1 1 HDAC2 8–13 HDAC3 398–458 HDAC4 >33,000 HDAC5 >33,000 HDAC6 >33,000 HDAC7 >33,000 HDAC8 >33,000 HDAC9 >33,000 HDAC10 3...

concentration (nM) HDAC1 5,600–28,670 HDAC2 3,010–17,680 HDAC3 80–401 HDAC4 >20,000 HDAC5 >20,000 HDAC6 >20,000 HDAC7 >20,000 HDAC8 >100,000 HDAC9 >20,000 HDAC10...

Genes encoding for adaptation to high altitudes air conditions including HDAC5, BMP2, and BMPR1B show higher selection due to the lower oxygen concentrations...

note HDAC1 16,000 HDAC2 12,000 HDAC3 9,000 HDAC4 2,000,000 Lower bound HDAC5 2,000,000 Lower bound HDAC6 2,000,000 Lower bound HDAC7 2,000,000 Lower...

concentration (nM) HDAC1 41–636 HDAC2 147–696 HDAC3 46–472 HDAC4 >33,000 HDAC5 >33,000 HDAC6 >33,000 HDAC7 >33,000 HDAC8 >33,000 HDAC9 >33,000 HDAC10 >10...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

signaling, which, in addition to phosphorylating CREB, also phosphorylates HDAC5. Figure 2: Psychostimulant-induced signaling events Broussard JI (January...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

interactions, though a mechanism involving p300/CBP-associated factor and HDAC5 has been proposed in the context of cardiac reprogramming. Generally, HDAC2...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

8 nM at the preceding HDACs, whereas no activity against the class IIa HDAC5 was observed. Activities at the class I HDAC8 and at the class IIb HDAC4...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

Half-maximal inhibitory concentration (nM) HDAC1 58 HDAC2 48 HDAC3 51 HDAC4 7,000 HDAC5 5,000 HDAC6 4.7 HDAC7 1,400 HDAC8 100 HDAC9 >10,000 HDAC10 ND HDAC11 >10...

the class I HDAC8, with no significant inhibition of the class IIa HDAC4, HDAC5, HDAC7, or HDAC9. The drug has been found to robustly activate CREB-mediated...

inhibitory concentration (μM) HDAC1 5,300 HDAC2 ND HDAC3 2,400 HDAC4 4,500 HDAC5 ND HDAC6 48,500 HDAC7 ND HDAC8 ND HDAC9 ND HDAC10 ND HDAC11 ND Note: BHB...

signaling, which, in addition to phosphorylating CREB, also phosphorylates HDAC5. Figure 2: Psychostimulant-induced signaling events Broussard JI (January...

has been shown to interact with: AR BCL6 C-Fos C-jun HDAC1 HDAC3 HDAC4 HDAC5 HDAC10 MeCP2 NR4A1 POU2F1 PPARD PGR PML RBPJ RELA RUNX1T1 RARA SIN3A SNW1...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

inhibitory concentration (nM) HDAC1 1,510 HDAC2 750 HDAC3 96 HDAC4 >20,000 HDAC5 >20,000 HDAC6 >20,000 HDAC7 >20,000 HDAC8 >20,000 HDAC9 >20,000 HDAC10 6...

context specific. In urothelial carcinoma cell lines overexpression of HDAC5 inhibits long-term proliferation but can promote epithelial-to-mesenchymal...

concentration (nM) HDAC1 133–198 HDAC2 293–325 HDAC3 136–157 HDAC4 1,059 HDAC5 532 HDAC6 312–315 HDAC7 524 HDAC8 837–854 HDAC9 512–541 HDAC10 331–340 HDAC11...

CD200, C-jun, CREBBP, CXCR5, EP300, EZH2, Gpr183, HDAC1, HDAC4, HDAC7A, HDAC5, ICOS, IRF8, IRF4, IL-6R, KM2TD, MET2B, NCOR2 NCOR2, SAP, Selplg, SMRT,...

middle of a depressive episode found increased expression of HDAC2 and HDAC5 mRNA compared to controls and patients in remission. As of 2011 various...

signaling, which, in addition to phosphorylating CREB, also phosphorylates HDAC5. Figure 2: Psychostimulant-induced signaling events Broussard JI (January...

do not have this dominant negative mutation. HDAC5 shows the opposite trend in the NaC. A lack of HDAC5 leads to an increase in depressive behaviors....

inhibitory concentration (nM) HDAC1 0.3 HDAC2 0.8–2.0 HDAC3 0.6 HDAC4 1,970 HDAC5 352 HDAC6 4.1 HDAC7 >20,000 HDAC8 >15,000 HDAC9 >15,000 HDAC10 ND HDAC11...

inhibitory concentration (nM) HDAC1 4.99 HDAC2 2.7 HDAC3 5.21 HDAC4 27.6 HDAC5 776 HDAC6 16.4 HDAC7 482 HDAC8 486 HDAC9 >1,000 HDAC10 24.3 HDAC11 >1,000...

consisting of HDAC1, HDAC2, HDAC3, HDAC8, class II, consisting of HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10, class III, consisting of NAD+-dependent HDACS...

at promoters, which affects gene expression. In mice, this regulation of HDAC5 has been shown to increase the amount of type I fibers in muscle. Type I...

compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5". Sci Adv. 3 (11) e1701682. Bibcode:2017SciA....3E1682G. doi:10.1126/sciadv...

muscle, brain GCMA, GATA1, HP1 RFXANK Defects in chondrocyte differentiation HDAC5 1 Nucleus / cytoplasm heart, skeletal muscle, brain GCMA, SMAD7, HP1 REA...

Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity"...

CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences...

shown to interact with: CBFA2T3, CCND1, GATA1, GATA2, GPS2, GTF2I, HDAC4, HDAC5, HDAC7A, HDAC9, MAP3K7IP2, MAPK11, NCOR1, NCOR2, PPARD, PPARG, PML RBBP4...

type 1, BCL6, BMI1, Calcitriol receptor, FHL2, GATA1, GATA2, HDAC1, HDAC4, HDAC5, HDAC6, Heparin-binding EGF-like growth factor, Nuclear receptor co-repressor...

thought to contribute to contractility. The Class IIA HDACs includes HDAC4, HDAC5, HDAC7 and HDAC9. HDACs 4 and 5 have been found to most closely resemble...

inhibitory concentration (nM) HDAC1 1–48 HDAC2 2–73 HDAC3 3–21 HDAC4 >25,000 HDAC5 >15,000 HDAC6 0.5–100 HDAC7 >25,000 HDAC8 290–1,410 HDAC9 >25,000 HDAC10...

cleft of CtBP. CtBP in turn recruits histone deacetylases (HDAC1, HDAC2, HDAC5) and other chromatin‑modifying factors, forming a compact silencing complex...

Okamoto M, Abe A, Naoe T, Saito H (Dec 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–84...

Miyata Y, Okamoto M, Abe A, et al. (December 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–9184...

concentration (nM) HDAC1 243–427 HDAC2 306–753 HDAC3 248–1,577 HDAC4 >100,000 HDAC5 >30,000 HDAC6 >100,000 HDAC7 >30,000 HDAC8 2,700–82,500 HDAC9 >30,000 HDAC10...

Q92769 6964 HDAC3 HGNC:4854; O15379 6965 HDAC4 HGNC:14063; P56524 6966 HDAC5 HGNC:14068; Q9UQL6 6967 HDAC6 HGNC:14064; Q9UBN7 6968 HDAC7 HGNC:14067;...

specifying the fates of multipotent retinal progenitors. Histone Deacetylase 5 (HDAC5) deacetylates lysine residues on the N-terminus tail of core histones and...

proteins (HIST1H2BE, HIST1H2BN and H3F3A), the histone deacetylase gene, HDAC5, two genes that produce helicase proteins (WRN and DDX3X), two genes that...

deacetylases (HDACs) 1, 2, 3 and 5 to repress p14ARF in breast cancer and with HDAC5 to repress E-cadherin to promote metastasis in hepatocellular carcinoma...

Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity"...

Okamoto M, Abe A, Naoe T, Saito H (December 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–84...

Molecular Cell, 44, 621-634. 2. Sen N, Kumari R, Singh MI and Das S*. HDAC5, a key component in temporal regulation of p53-mediated transactivation...

methylation, increase H3 acetylation at the BDNF promoter, and reduce levels of HDAC5. Recall that HDACs remove acetyl groups and are associated with heterochromatin...

disease. YWHAQ has been shown to interact with: BAX, BAD, C-Raf, CRTC2, CBL HDAC5, MEF2D, NRIP1, PFKFB2, PRKD1, PRKCZ, TERT, and UCP3. GRCh38: Ensembl release...