HBG2

HBG2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHBG2, HBG-T1, TNCY, hemoglobin subunit gamma 2
External IDsOMIM: 142250; MGI: 96027; HomoloGene: 128032; GeneCards: HBG2; OMA:HBG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3048

15135

Ensembl

ENSG00000196565

ENSMUSG00000052187

UniProt

P69892

P02104

RefSeq (mRNA)

NM_000184

NM_008221

RefSeq (protein)

NP_000175

NP_032247

Location (UCSC)Chr 11: 5.25 – 5.51 MbChr 7: 103.5 – 103.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.[5]

Function

The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196565 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052187 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  6. ^ "Entrez Gene: HBG2 hemoglobin, gamma G".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P69892 (Hemoglobin subunit gamma-2) at the PDBe-KB.


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