DOSEN PROFIL LENGKAP

Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. The protein encoded by this...

discovered was ERK1 (MAPK3) in mammals. Since ERK1 and its close relative ERK2 (MAPK1) are both involved in growth factor signaling, the family was termed...

signal-regulated kinase 2 (ERK2). Two similar protein kinases with 85% sequence identity were originally called ERK1 and ERK2. They were found during a...

Ser19 about half the rate of Ser40. Ser31 is phosphorylated by ERK1 and ERK2 (extracellular regulated kinases 1&2), and increases the enzyme activity...

serotonin 5-HT1A receptor, distinguished by its preference for activating ERK1/ERK2 phosphorylation pathways. This compound has demonstrated potent and rapid-acting...

2 (ERK2) signaling and not necessarily to other downstream signaling pathways. LSD has been found to have low activity on a valvulopathogenic ERK2 serotonin...

complex oligomerization positive regulation of ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of tumor necrosis factor production...

peptidyl-lysine deacetylation protein ADP-ribosylation negative regulation of ERK1 and ERK2 cascade positive regulation of insulin secretion negative regulation of reactive...

discovered roles for both BDNF and ERK2 in pain sensitization and developed novel siRNA technology to inhibit ERK2 as a treatment for pain. Garraway pursued...

of protein localization to cell surface positive regulation of ERK1 and ERK2 cascade glucose metabolic process animal organ morphogenesis apoptotic signaling...

Cynthia; Wood, Antony W.; Asara, John M.; Ben-Sahra, Issam (1 June 2020). "ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine...

angiogenesis regulation of MAPK cascade negative regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

stimulus nerve growth factor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of protein kinase activity positive regulation...

transferase activity neuron differentiation negative regulation of ERK1 and ERK2 cascade cell cycle negative regulation of type I interferon production positive...

accumulating to suggest that some GPCRs are able to signal without G proteins. The ERK2 mitogen-activated protein kinase, a key signal transduction mediator downstream...

negative regulation of release of cytochrome c from mitochondria ERK1 and ERK2 cascade water transport cell-cell signaling negative regulation of apoptotic...

receptors, and phosphorylation of the extracellular signal-regulated kinase ERK2), ropinirole was found to be "distinct from the seven known valvulopathic...

differentiation positive regulation of cell differentiation regulation of ERK1 and ERK2 cascade positive regulation of BMP signaling pathway positive regulation...

activation cellular response to hydrogen peroxide negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to interferon-gamma...

growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of cell population proliferation positive regulation...

Cynthia; Wood, Antony W.; Asara, John M.; Ben-Sahra, Issam (18 June 2020). "ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine...

biosynthetic process axon guidance positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus positive regulation...

polymerase II promoter in response to hypoxia positive regulation of ERK1 and ERK2 cascade positive regulation of neuron projection development negative regulation...

growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of phosphatidylinositol 3-kinase signaling platelet-derived...

heart looping cell growth vesicle docking positive regulation of ERK1 and ERK2 cascade positive regulation of neuron projection development brain development...

associated with cellular proliferation and differentiation. DUSP6 inactivates ERK2 and is expressed in a variety of tissues with the highest levels in heart...

immunological synapse Biological process meiosis I positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway...

1997). "Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6". FEBS Letters...

growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade peptidyl-tyrosine autophosphorylation protein autophosphorylation...

peptidyl-threonine phosphorylation feeding behavior positive regulation of ERK1 and ERK2 cascade positive regulation of protein binding cell population proliferation...

cytokine-mediated signaling pathway osteoclast differentiation ERK1 and ERK2 cascade paracrine signaling positive regulation of DNA-binding transcription...

response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma lymphocyte chemotaxis inflammatory...

biosynthetic process positive regulation of fibroblast proliferation ERK1 and ERK2 cascade negative regulation of extrinsic apoptotic signaling pathway cell...

expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in...

non-receptor type 7". Pettiford SM, Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene...

virus positive regulation of chemotaxis positive regulation of ERK1 and ERK2 cascade positive regulation of toll-like receptor 4 signaling pathway positive...

signal transduction by p53 class mediator positive regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-tyrosine phosphorylation cell-matrix...

microtubule-based process neuromuscular junction development regulation of ERK1 and ERK2 cascade myelination protein autophosphorylation phosphatidylinositol 3-kinase...

activity canonical Wnt signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of cell differentiation mesodermal cell fate determination...

phosphorylation cell adhesion regulation of neuron death regulation of ERK1 and ERK2 cascade protein autophosphorylation peptidyl-tyrosine phosphorylation immunological...

YY, Yao XB (Aug 2004). "Nek2A specifies the centrosomal localization of Erk2". Biochem. Biophys. Res. Commun. 321 (2): 495–501. doi:10.1016/j.bbrc.2004...

L, Gotoh N, Zhang S, et al. (2004). "SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation". Biochem. Biophys...

regulation of transcription, DNA-templated ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of cytokine production...

Tanner KG, Denu JM (May 1999). "Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase...

negative regulation of potassium ion transport positive regulation of ERK1 and ERK2 cascade artery smooth muscle contraction positive regulation of peptidyl-tyrosine...

"Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton". J. Cell Sci. 117 (Pt 10): 2151–7. doi:10.1242/jcs...

positive regulation of astrocyte activation positive regulation of ERK1 and ERK2 cascade cellular response to copper ion cellular response to manganese ion...

component cytoplasm nucleus Biological process negative regulation of ERK1 and ERK2 cascade negative regulation of TOR signaling negative regulation of protein...

response to insulin-like growth factor stimulus negative regulation of ERK1 and ERK2 cascade fatty acid homeostasis positive regulation of vascular associated...

Atkinson M, Goldsmith E, Cobb MH (May 1998). "Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation". Cell. 93 (4): 605–615...

MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38 are substrates for MAP2K4, but MAPK1/ERK2 and MAPK3/ERK1 are not phosphorylated by MAP2K4. Structurally, MAP2K4 contains...

expression protein phosphorylation spermatogenesis regulation of ERK1 and ERK2 cascade peptidyl-tyrosine autophosphorylation cell population proliferation...

negative regulation of cell proliferation, negative regulation of ERK1 and ERK2 cascade, negative regulation of Golgi to plasma membrane protein transport...

Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2". Molecular Biology of the Cell. 12 (6): 1811–1817. doi:10.1091/mbc.12.6...

concentration response to progesterone response to amphetamine ERK1 and ERK2 cascade regulation of systemic arterial blood pressure by vasopressin response...

response to morphine response to iron ion positive regulation of ERK1 and ERK2 cascade long-term memory positive regulation of renal sodium excretion negative...

signaling pathway chemical synaptic transmission positive regulation of ERK1 and ERK2 cascade positive regulation of arachidonic acid secretion negative regulation...

Cellular component cytoplasm Biological process negative regulation of ERK1 and ERK2 cascade regulation of transcription, DNA-templated positive regulation of...

negative regulation of sprouting angiogenesis negative regulation of ERK1 and ERK2 cascade protein targeting Rho protein signal transduction regulation of endocytosis...

Biological process C-terminal protein lipidation negative regulation of ERK1 and ERK2 cascade regulation of neurotransmitter receptor activity Sources:Amigo /...

A., Loftus, M.S., and Kedes, D.H. Progressive accumulation of activated ERK2 within highly stable ORF45-containing nuclear complexes promotes lytic gammaherpesvirus...

regulation of fibroblast proliferation cellular sodium ion homeostasis ERK1 and ERK2 cascade activation of phospholipase C activity angiotensin maturation positive...

signal transduction cell differentiation positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo...

signaling pathway removal of superoxide radicals astrocyte development ERK1 and ERK2 cascade negative regulation of neurogenesis regulation of response to food...

through the phosphorylation of the mitogen-activated protein kinases ERK1 and ERK2. HMB-induced human myosatellite differentiation and accelerated fusion of...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade phagocytosis regulation of growth activation of protein kinase B...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade immune response cellular response to interferon-gamma regulation...

phosphatidylinositol-4,5-bisphosphate 3-kinase-γ (PI3Kγ)/Akt, MAP kinases such as ERK1/ERK2 or phospholipase-β (PLCβ) signaling pathways. CXCL1 is expressed at higher...

positive regulation of CD4-positive, alpha-beta T cell proliferation ERK1 and ERK2 cascade female pregnancy positive regulation of viral entry into host cell...

positive regulation of astrocyte activation positive regulation of ERK1 and ERK2 cascade regulation of spontaneous synaptic transmission regulation of long-term...

regulation of cell projection organization positive regulation of ERK1 and ERK2 cascade regulation of cell differentiation branching morphogenesis of an...

negative regulation of release of cytochrome c from mitochondria ERK1 and ERK2 cascade water transport cell-cell signaling negative regulation of apoptotic...

Malavika; Cobb Melanie H (Apr 2002). "Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1". J. Biol. Chem. 277 (17). United...

arachidonic acid release, extracellular signal-regulated protein kinase 1 (ERK1), ERK2, and p38 MAP kinase phosphorylation. Although GnRH is located in many areas...

transport excitatory postsynaptic potential positive regulation of ERK1 and ERK2 cascade behavioral response to ethanol response to food sensory perception...

negative regulation of inflammatory response phospholipid homeostasis ERK1 and ERK2 cascade negative regulation of cytokine production involved in immune response...

PMID 9003777. Pearson G, English JM, White MA, Cobb MH (March 2001). "ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation". The Journal of...

negative regulation of neuron apoptotic process positive regulation of ERK1 and ERK2 cascade manganese ion transmembrane transport regulation of zinc ion transport...

enzymes, most notably protein kinase. Ahn conducts research which focuses on ERK2 MAP kinases, that provide an ideal model due to their clear link between...

positive regulation of DNA biosynthetic process positive regulation of ERK1 and ERK2 cascade positive regulation of apoptotic process homocysteine metabolic process...

positive regulation of ERK1 and ERK2 cascade positive regulation of complement activation negative regulation of ERK1 and ERK2 cascade progesterone receptor...

regulation of MHC class I biosynthetic process negative regulation of ERK1 and ERK2 cascade negative regulation of NF-kappaB transcription factor activity negative...

J, Chen GQ (2010). "The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation". Leukemia....

macropinocytosis positive regulation of phagocytosis positive regulation of ERK1 and ERK2 cascade positive regulation of T cell migration positive regulation of defense...

spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta". J...

of synaptic transmission, glutamatergic positive regulation of ERK1 and ERK2 cascade phosphatidylinositol phosphate biosynthetic process circadian rhythm...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO Orthologs Databases NCBI: entry;...

regulation of interleukin-1 beta production positive regulation of ERK1 and ERK2 cascade positive regulation of interleukin-6 production positive regulation...

development coronary vasculature development positive regulation of ERK1 and ERK2 cascade positive regulation of trophoblast cell migration positive regulation...

MET and its downstream effector extracellular signal-regulated kinase 2 (ERK2) by miR-199a* may be effective in inhibiting not only cell proliferation...

proliferation angiogenesis Tie signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of angiogenesis protein autophosphorylation positive...

MAPK, Pi3K and insulin pathways. It was found to form a complex with MEK1 (Erk2, p38), MEK2, cdk4, PI3k, the phosphatases PP2A and PP^, and also various...

receptor signaling pathway feeding behavior positive regulation of ERK1 and ERK2 cascade regulation of corticotropin-releasing hormone secretion regulation...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade immune response cellular response to interferon-gamma regulation...

binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype...

migration regulation of protein kinase B signaling regulation of ERK1 and ERK2 cascade leukocyte differentiation Ras protein signal transduction face morphogenesis...

kinases have been linked to DAT regulation including PKA, PKC, PI-3K, ERK1, ERK2, Akt, CaMKII, CDK5, and MAPK. NET is responsible for the Na +/Cl − -dependent...

complications of type 2 diabetes. CCL2 induces amylin expression through ERK1/ERK2/JNK-AP1 and NF-κB related signaling pathways independent of CCR2. Amylin...

response negative regulation of MAPK cascade negative regulation of ERK1 and ERK2 cascade innate immune response inflammatory response G protein-coupled receptor...

of B cell apoptotic process angiogenesis positive regulation of ERK1 and ERK2 cascade negative regulation of epithelial cell proliferation long-term depression...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade neurogenesis Sources:Amigo / QuickGO Orthologs Databases NCBI: entry;...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade negative regulation of wound healing ubiquinone metabolic process...

protein-coupled receptor signaling pathway positive regulation of ERK1 and ERK2 cascade amyloid-beta clearance Sources:Amigo / QuickGO Orthologs Databases...

presentation of peptide antigen via MHC class II positive regulation of ERK1 and ERK2 cascade signal transduction osteoclast differentiation positive regulation...

regulation of T cell chemotaxis angiogenesis positive regulation of ERK1 and ERK2 cascade epidermis development innate immune response antimicrobial humoral...

OM, Gabrielsen M, Keyse SM (May 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity...

process cellular amino acid biosynthetic process regulation of ERK1 and ERK2 cascade apoptotic process pyroptosis protein homotetramerization L-methionine...

muramyl dipeptide protein phosphorylation positive regulation of ERK1 and ERK2 cascade cellular response to peptidoglycan positive regulation of stress-activated...

ubiquitin ligase complex Biological process negative regulation of ERK1 and ERK2 cascade microtubule nucleation axon guidance MAPK cascade protein-containing...

cell regulation of calcium ion transport positive regulation of ERK1 and ERK2 cascade cellular response to granulocyte macrophage colony-stimulating factor...

secretion chloride transmembrane transport positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

nervous system process sensory processing positive regulation of ERK1 and ERK2 cascade calcium ion transmembrane transport acetylcholine receptor signaling...

sensory neuron axon guidance angiogenesis positive regulation of ERK1 and ERK2 cascade animal organ morphogenesis protein localization to early endosome...

Huang L, Fukuyo Y, et al. (September 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research...

regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif". EMBO J. 17 (24): 7337–50...

GTPase activity blood vessel development negative regulation of ERK1 and ERK2 cascade platelet-derived growth factor receptor signaling pathway negative...

mice showed chemerin stimulates the phosphorylation of the MAPKs, ERK1, and ERK2, which are involved in mediating lipolysis. Studies in mice have shown neither...

positive regulation of interleukin-8 production positive regulation of ERK1 and ERK2 cascade T-helper 1 type immune response positive regulation of platelet activation...

process multicellular organism development negative regulation of ERK1 and ERK2 cascade regulation of signal transduction negative regulation of fibroblast...

proliferation intracellular protein transport positive regulation of ERK1 and ERK2 cascade negative regulation of intrinsic apoptotic signaling pathway in response...

to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2". J. Biol. Chem. 276 (43): 39950–8. doi:10.1074/jbc.M107807200. PMID 11546790...

positive regulation of T cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of innate immune response negative regulation...

"Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2". Biochemical and Biophysical Research Communications. 291 (5): 1146–1150...

regulation of receptor catabolic process negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine dephosphorylation negative regulation of PERK-mediated...

signal transduction signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of GTPase activity Sources:Amigo / QuickGO Orthologs...

Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex". J. Biol. Chem. 271 (43): 26962–70. doi:10.1074/jbc...

OM, Gabrielsen M, Keyse SM (May 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity...

growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade regulation of podosome assembly cell cycle substrate adhesion-dependent...

signaling pathway regulation of protein localization to cell surface ERK1 and ERK2 cascade platelet degranulation regulation of calcium ion import mammary gland...

growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1. The activation of this kinase itself is dependent on the...

transmission positive regulation of glial cell proliferation regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide...

serine phosphorylation by mTORC1 and extracellular signal–regulated kinase 2 (ERK2). mTORC1 phosphorylation of TFEB occurs at the lysosomal surface, both of...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways". Biochem Biophys Res Commun. 274 (3): 872–9. doi:10...

positive regulation of protein localization positive regulation of ERK1 and ERK2 cascade positive regulation of long-term neuronal synaptic plasticity positive...

insulin stimulus cellular response to phorbol 13-acetate 12-myristate ERK1 and ERK2 cascade positive regulation of intracellular mRNA localization cellular response...

negative regulation of mesoderm development negative regulation of ERK1 and ERK2 cascade signal transduction DNA damage response, signal transduction by p53...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to nerve growth factor stimulus regulation of MAPK...

ventricular cardiac muscle tissue morphogenesis positive regulation of ERK1 and ERK2 cascade transforming growth factor beta receptor signaling pathway involved...

negative regulation of viral genome replication positive regulation of ERK1 and ERK2 cascade positive regulation of innate immune response cellular response to...

regulation of osteoblast differentiation positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis cellular iron ion homeostasis cellular...

regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of ERK1 and ERK2 cascade negative regulation of macrophage derived foam cell differentiation...

regulation of Ras protein signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of transcription of Notch receptor target positive...

inflammatory response to antigenic stimulus positive regulation of ERK1 and ERK2 cascade blood circulation Sources:Amigo / QuickGO Orthologs Databases NCBI:...

membrane membrane cytosol Biological process negative regulation of ERK1 and ERK2 cascade protein autophosphorylation protein phosphorylation positive regulation...

positive regulation of DNA biosynthetic process positive regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-tyrosine phosphorylation cell chemotaxis...

blood vessel endothelial cell migration positive regulation of ERK1 and ERK2 cascade positive regulation of vascular associated smooth muscle cell proliferation...

pathways. CRABP1 activates the extracellular signal-regulated kinase, ERK1 and ERK2 kinases, which are involved in the cell cycle. CRABP1 activity can thus extend...

differentiation positive regulation of gene expression positive regulation of ERK1 and ERK2 cascade positive regulation of toll-like receptor 4 signaling pathway negative...

induced up-regulation and activation in three proteins (p66Shc, Erk1, and Erk2). (+)-Discodermolide has also been found to be neuroprotective in recent...

of T cell activation positive chemotaxis positive regulation of ERK1 and ERK2 cascade negative regulation of neuron death negative regulation of G1/S transition...

1997). "Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6". FEBS Letters...

this will activate them too. The targets of the kinase cascade are ERK1 and ERK2, that are selectively activated by MKK1 or MKK2. ERKs have numerous substrates...

regulation of tumor necrosis factor production positive regulation of ERK1 and ERK2 cascade regulation of signaling receptor activity Sources:Amigo / QuickGO...

regulation of hepatic stellate cell migration positive regulation of ERK1 and ERK2 cascade cellular response to interleukin-1 cellular response to tumor necrosis...

low-density lipoprotein particle remodeling positive regulation of ERK1 and ERK2 cascade phosphatidylglycerol acyl-chain remodeling phosphatidic acid metabolic...

regulation of cell cycle G1/S phase transition positive regulation of ERK1 and ERK2 cascade negative regulation of transcription, DNA-templated negative regulation...

regeneration methylation peptidyl-arginine methylation regulation of ERK1 and ERK2 cascade regulation of DNA methylation cell population proliferation Golgi...

regulation of dopaminergic neuron differentiation regulation of ERK1 and ERK2 cascade positive regulation of neuron projection development positive regulation...

population proliferation regulation of cell shape regulation of ERK1 and ERK2 cascade cell-substrate junction assembly substrate adhesion-dependent cell...

membrane protein proteolysis positive regulation of cell migration ERK1 and ERK2 cascade zymogen activation neuropeptide catabolic process positive regulation...

damage and other stressors increase p21 levels, while mitogen-stimulated ERK2 and Akt activity leads to inactivating phosphorylation of p21.   Early work...

regulation of cell population proliferation negative regulation of ERK1 and ERK2 cascade activation of protein kinase activity negative regulation of mitotic...

coagulation cellular response to hydroperoxide positive regulation of ERK1 and ERK2 cascade receptor internalization cellular response to bacterial lipopeptide...

Tanner K G; Denu J M (May 1999). "Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase...

vascular endothelial growth factor stimulus negative regulation of ERK1 and ERK2 cascade negative regulation of vascular endothelial growth factor signaling...

phosphorylation cellular response to insulin stimulus negative regulation of ERK1 and ERK2 cascade regulation of keratinocyte differentiation lung alveolus development...

Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex". The Journal of Biological Chemistry. 271 (43): 26962–70...

positive regulation of interleukin-8 production positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis positive regulation...

phosphorylation negative regulation of cell death positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus negative regulation...

migration positive regulation of angiogenesis positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

of ERK1 and ERK2 cascade cellular response to insulin stimulus negative regulation of MAPK cascade negative regulation of ERK1 and ERK2 cascade negative...

pathway-restricted SMAD protein phosphorylation negative regulation of ERK1 and ERK2 cascade positive regulation of extracellular matrix assembly negative regulation...

of gene expression cell differentiation positive regulation of ERK1 and ERK2 cascade myeloid progenitor cell differentiation visual learning negative...

chemotaxis neutrophil chemotaxis immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma regulation of signaling receptor...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade protein autophosphorylation peptidyl-tyrosine phosphorylation endochondral...

proliferation negative regulation of MAPK cascade regulation of ERK1 and ERK2 cascade negative regulation of B cell receptor signaling pathway peptidyl-tyrosine...

regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade amylin receptor signaling pathway response to amyloid-beta positive...

differentiation pericardium development positive regulation of ERK1 and ERK2 cascade BMP signaling pathway involved in heart induction animal organ morphogenesis...

regulation of alkaline phosphatase activity positive regulation of ERK1 and ERK2 cascade cell-matrix adhesion positive regulation of smooth muscle contraction...

cycle negative regulation of proteolysis negative regulation of ERK1 and ERK2 cascade negative regulation of cyclin-dependent protein kinase activity Sources:Amigo...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade anatomical structure development Sources:Amigo / QuickGO Orthologs...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade hematopoietic progenitor cell differentiation B cell differentiation...

"miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2". Oncotarget. 5 (19): 9444–59. doi:10.18632/oncotarget.2452. PMC 4253445...

nigra development Wnt signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of platelet-derived growth factor production signal transduction...

inhibits the MAPK signaling is by interacting with the MAP kinases Erk1, Erk2, and p38 through a short sequence in HePTP's non-catalytic N terminus termed...

Various Energy metabolism Apoptosis DLD H. sapiens Energy metabolism Protease ERK2 H. sapiens MAP kinase Transcriptional repressor ESCRT-II complex D. melanogaster...

regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade positive regulation of cell population proliferation myeloid cell...

enabled substrate profiling of several other kinases, including CDK1, Pho85, ERK2, and JNK. Whereas bumped ATM analogs can help deconvolute kinase substrate...

osteoclast differentiation signal transduction positive regulation of ERK1 and ERK2 cascade cannabinoid signaling pathway positive regulation of cytosolic calcium...

rela, nf-kb2, relb), grb2, grb3-3, traf3ip2, junB, c-myb, pu.1, akt1, tyk2, erk2, and mek2. In the same cells, the stable expression of TRIM14 allowed the...

"Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2)". Biochemical and Biophysical Research Communications. 288 (2): 313–20....

signaling cardiac muscle tissue regeneration positive regulation of ERK1 and ERK2 cascade negative regulation of oxidative stress-induced cell death negative...

TRAIL-activated apoptotic signaling pathway negative regulation of ERK1 and ERK2 cascade negative regulation of membrane protein ectodomain proteolysis visual...

which inhibits its transcriptional activity, is induced by Protein Kinase C. ERK2: Extracellular signal-regulated kinase-2 also phosphorylates RORα. ATXN1:...

cancer cells. Phosphorylation of PKM2 by Mitogen-activated protein kinase 1 (ERK2) causes conformational changes that allow PKM2 to enter the nucleus and regulate...

protein ubiquitination lipid homeostasis positive regulation of ERK1 and ERK2 cascade regulation of cell cycle G1/S phase transition regulation of lipid...

insulin stimulus response to testosterone positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response...

positive regulation of cell population proliferation regulation of ERK1 and ERK2 cascade negative regulation of NF-kappaB transcription factor activity homeostatic...

oxygen species metabolic process angiogenesis positive regulation of ERK1 and ERK2 cascade long-term depression positive regulation of excitatory postsynaptic...

regulation of cell population proliferation negative regulation of ERK1 and ERK2 cascade epithelial to mesenchymal transition involved in cardiac fibroblast...

phosphatidylglycerol acyl-chain remodeling positive regulation of ERK1 and ERK2 cascade response to cAMP leukotriene biosynthetic process phosphatidylcholine...

The well-known EGFR-activated extracellular signal-regulated kinase 2 (ERK2) and death-associated protein kinase are both shown to bind and directly...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade signal transduction axon guidance multicellular organism development...

regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

Henderson MJ, Watts CK, Shokat KM, et al. (April 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". The Journal...

Baillie GS, MacKenzie SJ, Yarwood SJ, Houslay MD (Feb 1999). "The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating...

protein-coupled receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of vascular associated smooth muscle cell proliferation...

positive regulation of protein secretion positive regulation of ERK1 and ERK2 cascade negative regulation of blood coagulation, common pathway positive...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway...

regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade amylin receptor signaling pathway positive regulation of protein...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade phosphatidylinositol phosphate biosynthetic process...

regulation of calcium-mediated signaling negative regulation of ERK1 and ERK2 cascade negative regulation of substrate adhesion-dependent cell spreading...

Third, Ets1 can be activated by Erk2 and Ras at Thr38. The truncated isoform cannot be phosphorylated by the Erk2. It is localized in the cytoplasm...

population proliferation spermatid development positive regulation of ERK1 and ERK2 cascade cytoplasmic microtubule organization endomitotic cell cycle cell...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade nervous system development positive regulation of cell population...

peptidyl-threonine phosphorylation feeding behavior positive regulation of ERK1 and ERK2 cascade positive regulation of protein binding cell population proliferation...

phosphorylation cellular response to interleukin-1 positive regulation of ERK1 and ERK2 cascade inflammatory response apoptotic process neutrophil degranulation...

is additionally phosphorylated by the kinases MSK1, ERK1, p38, FYN, MLTK, ERK2, and to a lesser extent JNK1 and JNK2. The genomic DNA of eukaryotic cells...

phosphorylation positive regulation of cytokine production vasoconstriction ERK1 and ERK2 cascade positive regulation of phosphatidylinositol biosynthetic process...

in tissue homeostasis ureter smooth muscle cell differentiation ERK1 and ERK2 cascade notochord development positive regulation of epithelial cell migration...

regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade negative regulation of cell proliferation involved in kidney development...

protein-coupled receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of extrinsic apoptotic signaling pathway cell...

Rousseau S (2006). "Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ". Biochem. J. 399 (2): 265–73. doi:10.1042/BJ20060681...

induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases". Blood. 95 (6): 1911–1917. doi:10...

response establishment of T cell polarity positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis positive regulation...

associated smooth muscle cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of reactive oxygen species metabolic process...

inhibiting the actions of extracellular signal–regulated kinases (ERK1 and ERK2) that lead to lysomal degradation. The NKCC1/2 cotransporters are regulated...

regulates the activity of ERK2 by deposphorylating it and holding it in the cytoplasmic region. MKP-3 also binds to ERK2 regardless of whether it is...

0022-202x.2001.01565.x. PMID 11886499. Chen YJ, Wang YN, Chang WC (2007). "ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation...

angiogenesis prostate gland morphogenesis positive regulation of ERK1 and ERK2 cascade orbitofrontal cortex development negative regulation of epithelial...

transport integrin-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade positive regulation of focal adhesion assembly cellular response...

development regulation of immune response positive regulation of ERK1 and ERK2 cascade regulation of ruffle assembly viral entry into host cell response...

signaling pathway response to sodium phosphate positive regulation of ERK1 and ERK2 cascade positive regulation of vitamin D 24-hydroxylase activity phosphate-containing...

signaling pathway in response to DNA damage positive regulation of ERK1 and ERK2 cascade substrate adhesion-dependent cell spreading platelet-derived growth...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade anatomical structure development Sources:Amigo / QuickGO Orthologs...

involved in prostate glandular acinus morphogenesis regulation of ERK1 and ERK2 cascade neuroblast proliferation forebrain development regulation of epithelial...

S1P. The signal pathway involves RAC-CDC42 and correlates with ERK1 and ERK2 activation. The RAC-CDC42 pathway leads to cell migration, whereas the ERK...

spermatogenesis hormone-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of phosphatidylinositol 3-kinase signaling gonad...

of adenosine receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of glutamate receptor signaling pathway negative...

to cell spreading, phosphorylation of focal adhesion kinase, paxillin and ERK2 MAPK, and proliferation. In contrast, when these same cells use either α9β1...

Karandikar M, Xu S, Cobb MH (December 2000). "MEKK1 binds raf-1 and the ERK2 cascade components". The Journal of Biological Chemistry. 275 (51): 40120–7...

deubiquitination ventricular septum morphogenesis negative regulation of ERK1 and ERK2 cascade negative regulation of cardiac myofibril assembly protein homotrimerization...

GTPase activity positive regulation of protein import regulation of ERK1 and ERK2 cascade regulation of Rho protein signal transduction regulation of cytoskeleton...

regulation of astrocyte differentiation negative regulation of ERK1 and ERK2 cascade neuron development decidualization positive regulation of mesenchymal...

osteoblast differentiation immune response positive regulation of ERK1 and ERK2 cascade axon extension olfactory lobe development integrin-mediated signaling...

weakly stimulates the mitogen-activated protein kinase (MAPK) activity and ERK2 activity, but modestly stimulates trans-activation from different nuclear...

regulation of endothelial cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of GTPase activity positive regulation of angiogenesis...

pathway cell chemotaxis pharynx development positive regulation of ERK1 and ERK2 cascade cellular response to transforming growth factor beta stimulus response...

central nervous system neuron development positive regulation of ERK1 and ERK2 cascade metanephros development cell proliferation in forebrain positive...

process 3'-phosphoadenosine 5'-phosphosulfate metabolic process ERK1 and ERK2 cascade calcineurin-mediated signaling NMDA selective glutamate receptor...

of T cell proliferation immune response positive regulation of ERK1 and ERK2 cascade establishment of T cell polarity positive regulation of glycoprotein...

regulation of cardiac muscle contraction positive regulation of ERK1 and ERK2 cascade positive regulation of protein phosphorylation integrin-mediated...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade hematopoietic progenitor cell differentiation leukocyte differentiation...

Yamada K; Ikeda T; Takeuchi A; Hiramoto T; Watanabe Y; Kazama T (Aug 2011). "ERK2 contributes to the control of social behaviors in mice". J Neurosci. 31 (33):...

- ERKs or MAP/ERK kinase (MEK)). As a result of the last step, ERK1 and ERK2 are activated. The phosphorylated forms of ERKs can continue the cascade...

adhesion response to wounding immune response positive regulation of ERK1 and ERK2 cascade inflammatory response calcium ion transport signal transduction exocytosis...

involved in inflammatory response wound healing positive regulation of ERK1 and ERK2 cascade regulation of interleukin-1 beta production positive regulation of...

positive regulation of protein secretion positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis blood coagulation, fibrin clot...

space cytoplasm cytosol Biological process positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus positive regulation of cell...

PMID 11266503. Ho PC, Gupta P, Tsui YC, et al. (2008). "Phosphorylation of RIP140 by ERK2 modulates its corepressor activity". J Biol Chem. 283 (20): 13879–88. doi:10...

positive regulation of cell differentiation positive regulation of ERK1 and ERK2 cascade positive regulation of transforming growth factor beta production...

polymerase II response to glucocorticoid positive regulation of ERK1 and ERK2 cascade positive regulation of wound healing positive regulation of NIK/NF-kappaB...

transduction regulation of synapse assembly negative regulation of ERK1 and ERK2 cascade postsynaptic membrane assembly neuron projection retraction positive...

cascade intracellular signal transduction positive regulation of ERK1 and ERK2 cascade signal transduction organ growth cell-cell signaling positive regulation...

"Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton". J. Cell Sci. 117 (Pt 10): 2151–7. doi:10.1242/jcs...

expression negative regulation of growth rate positive regulation of ERK1 and ERK2 cascade regulation of osteoclast development positive regulation of keratinocyte...

cellular response to tumor necrosis factor positive regulation of ERK1 and ERK2 cascade inflammatory response positive regulation of GTPase activity G protein-coupled...

response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma lymphocyte chemotaxis inflammatory...

(Jun 2002). "Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation". Genes...

guidance positive regulation of gene expression negative regulation of ERK1 and ERK2 cascade protein localization to cell cortex regulation of microvillus length...

protein phosphorylation circadian rhythm positive regulation of ERK1 and ERK2 cascade B cell differentiation response to ethanol innervation negative regulation...

IRES-dependent viral translational initiation negative regulation of ERK1 and ERK2 cascade translation reinitiation cytoplasmic translational initiation Sources:Amigo...

actions of pro-inflammatory cytokines; c) inhibiting the activation of ERK1, ERK2, Akt and a p38 mitogen-activated protein kinases pathways to inhibit the...

Dorsey JF, Cunnick JM, Mane SM, Wu J (February 2002). "Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562...

Ericson J, Rutberg M, Magnusson B, Marchesan D, et al. (June 2006). "PLD1 and ERK2 regulate cytosolic lipid droplet formation". Journal of Cell Science. 119...

transport zygote asymmetric cell division negative regulation of ERK1 and ERK2 cascade cell cycle platelet-derived growth factor receptor signaling pathway...

predicted by homology modelling using the crystal structure of phoshphorylated ERK2. According to the model, the structure of ERK3/MAPK6 kinase domain resembles...

hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins". Molecular and Cellular Endocrinology...

response establishment of T cell polarity positive regulation of ERK1 and ERK2 cascade positive regulation of glycoprotein biosynthetic process cellular...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to nerve growth factor stimulus regulation of MAPK...

elongation from RNA polymerase II promoter positive regulation of ERK1 and ERK2 cascade positive regulation of viral transcription transcription by RNA polymerase...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway...

signal transduction cell differentiation positive regulation of ERK1 and ERK2 cascade regulation of neuron differentiation Sources:Amigo / QuickGO Orthologs...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade animal organ morphogenesis T-helper 1 type immune response Ras protein...

response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade regulation of cell shape positive regulation of tumor necrosis factor...

regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion positive regulation of protein kinase...

synapse organization sensory processing positive regulation of ERK1 and ERK2 cascade calcium ion transmembrane transport acetylcholine receptor signaling...

regulation of engulfment of apoptotic cell positive regulation of ERK1 and ERK2 cascade inflammatory response cellular response to interleukin-13 positive...

Dalby KN (2007). "Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer". Arch. Biochem. Biophys. 460...

activity positive regulation of gene expression negative regulation of ERK1 and ERK2 cascade integrin-mediated signaling pathway blood coagulation, fibrin clot...

PMID 8681137. Toth-Zsamboki E, Oury C, Cornelissen H (2003). "P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing...

transduction ion transmembrane transport negative regulation of ERK1 and ERK2 cascade chemical synaptic transmission regulation of membrane potential nervous...

proliferation negative regulation of MAP kinase activity regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-tyrosine phosphorylation erythrocyte...

regulation of tumor necrosis factor production positive regulation of ERK1 and ERK2 cascade positive regulation of I-kappaB kinase/NF-kappaB signaling positive...

nucleus Protein phosphorylation The closest human homolog to Fus3 is MAPK1 (ERK2) Malleshaiah, Mohan (6 May 2010). "The scaffold protein Ste5 directly controls...

of epithelial cell apical/basal polarity negative regulation of ERK1 and ERK2 cascade adenylate cyclase-activating dopamine receptor signaling pathway...

Henderson MJ, Watts CK, Shokat KM, Weber MJ (Apr 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". The Journal...

regulation of peptidyl-serine phosphorylation negative regulation of ERK1 and ERK2 cascade positive regulation of sodium ion transmembrane transporter activity...

membrane cellular component Biological process positive regulation of ERK1 and ERK2 cascade immune response phospholipase C-activating G protein-coupled receptor...

regulation of calcium ion-dependent exocytosis positive regulation of ERK1 and ERK2 cascade cellular response to organic cyclic compound cellular response to...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway...

factor activity circadian rhythm angiogenesis positive regulation of ERK1 and ERK2 cascade Ras protein signal transduction transforming growth factor beta receptor...

regulation of cell death chemoattraction of axon positive regulation of ERK1 and ERK2 cascade amyloid-beta clearance by transcytosis amyloid-beta clearance by...

process negative regulation of GTPase activity positive regulation of ERK1 and ERK2 cascade positive regulation of insulin secretion involved in cellular response...

duct morphogenesis regulation of cell-cell adhesion regulation of ERK1 and ERK2 cascade positive regulation of apoptotic process peptidyl-tyrosine phosphorylation...

positive regulation of gene expression protein-DNA complex disassembly ERK1 and ERK2 cascade cellular response to hypoxia G1/S transition of mitotic cell cycle...

development chemotaxis cell adhesion angiogenesis positive regulation of ERK1 and ERK2 cascade viral process signal transduction positive regulation of mesenchymal...

regulation of transcription by RNA polymerase II negative regulation of ERK1 and ERK2 cascade negative regulation of transcription by RNA polymerase II endoplasmic...

adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation...

proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2)". The Journal of Biological Chemistry. 283 (26): 18158–66. doi:10.1074/jbc...

transduction ion transmembrane transport negative regulation of ERK1 and ERK2 cascade chemical synaptic transmission regulation of membrane potential nervous...

positive regulation of inflammatory response positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

interleukin-1 leukocyte adhesive activation positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cell chemotaxis lymphocyte...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway...

angiogenesis prostate gland morphogenesis positive regulation of ERK1 and ERK2 cascade smooth muscle tissue development BMP signaling pathway involved in...

including enhancing the intensity and sustaining the duration of ERK1 / ERK2 activation through the map kinase (MAPK) pathway, pp60 (c-src), and the downstream...

negative regulation of potassium ion transport positive regulation of ERK1 and ERK2 cascade positive regulation of interleukin-6 production positive regulation...

serine/threonine-specific protein kinase family. This kinase can activate ERK1, ERK2 and p38 MAP kinases. This kinase was shown to activate IkappaB kinases, and...

cyclase-modulating G protein-coupled receptor signaling pathway ERK1 and ERK2 cascade response to mechanical stimulus negative regulation of eosinophil...

chemotaxis regulation of inflammatory response positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis cellular response to...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade phagocytosis lymphocyte activation viral entry into host cell negative...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade embryonic cranial skeleton morphogenesis liver development positive...

positive regulation of prostaglandin secretion positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling positive regulation of cell population...

positive regulation of protein secretion positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis blood coagulation, fibrin clot...

positive regulation of synaptic transmission positive regulation of ERK1 and ERK2 cascade positive regulation of excitatory postsynaptic potential transforming...

necrosis factor production signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of epithelial cell proliferation regulation of...

proliferation involved in metanephros development positive regulation of ERK1 and ERK2 cascade cell chemotaxis inner ear development metanephric S-shaped body morphogenesis...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade anatomical structure development Sources:Amigo / QuickGO Orthologs...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

PMC 1965536. PMID 17563371. Roy M, Li Z, Sacks DB (April 2004). "IQGAP1 binds ERK2 and modulates its activity". Journal of Biological Chemistry. 279 (17): 17329–17337...

Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK (Oct 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required...

response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma lymphocyte chemotaxis inflammatory...

regulation of stress-activated MAPK cascade positive regulation of ERK1 and ERK2 cascade negative regulation of epithelial cell proliferation regulation of...

regulation of transcription, DNA-templated positive regulation of ERK1 and ERK2 cascade cell-cell adhesion interleukin-15-mediated signaling pathway negative...

Karandikar M, Xu S, Cobb MH (December 2000). "MEKK1 binds raf-1 and the ERK2 cascade components". The Journal of Biological Chemistry. 275 (51): 40120–40127...

response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma lymphocyte chemotaxis inflammatory...

response cellular response to interleukin-1 positive regulation of ERK1 and ERK2 cascade regulation of cell shape cellular response to interferon-gamma lymphocyte...

regulation of cytosolic calcium ion concentration positive regulation of ERK1 and ERK2 cascade neuropeptide signaling pathway feeding behavior G protein-coupled...

response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade regulation of cell shape cellular response to interferon-gamma inflammatory...

positive regulation of DNA biosynthetic process positive regulation of ERK1 and ERK2 cascade positive regulation of proteolysis protein autophosphorylation peptidyl-tyrosine...

establishment of mitotic spindle orientation positive regulation of ERK1 and ERK2 cascade embryonic digestive tract morphogenesis animal organ morphogenesis...

regulation of transcription, DNA-templated positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry...

5 production cell-cell junction assembly positive regulation of ERK1 and ERK2 cascade hypotonic response positive regulation of macrophage inflammatory...

proliferation neural crest cell migration positive regulation of ERK1 and ERK2 cascade positive regulation of protein localization to cell surface protein...

differentiation regulation of transcription by RNA polymerase I ERK1 and ERK2 cascade in utero embryonic development mammary gland branching involved in...

CJ (February 1992). "Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein". EMBO J. 11 (2): 569–74. doi:10.1002/j.1460-2075...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO Orthologs Databases NCBI: entry;...

anatomical structure Biological process positive regulation of ERK1 and ERK2 cascade brain-derived neurotrophic factor receptor signaling pathway cellular...

fibroblast growth factor stimulus phosphorylation positive regulation of ERK1 and ERK2 cascade negative regulation of apoptotic process Sources:Amigo / QuickGO...

regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif". The EMBO Journal. 17...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus positive regulation of...

Takahashi M, Sarcevic B, Lal P, Graham ME, et al. (October 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required...

immune response response to peptidoglycan positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis complement receptor...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade apoptotic process involved in morphogenesis signal transduction cell-cell...

proliferation immune response signal transduction positive regulation of ERK1 and ERK2 cascade immune system process regulation of astrocyte chemotaxis leukocyte...

regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif". The EMBO Journal. 17...

pathway in absence of ligand positive regulation of cell adhesion ERK1 and ERK2 cascade cell growth positive regulation of osteoblast proliferation cell...

therefore the transcriptional activity of USF. ERK1 (also known as MAPK3) and ERK2 (also known as MAPK1) phosphorylate USF1 in response to TFG-β signaling in...

regulation of protein autophosphorylation positive regulation of ERK1 and ERK2 cascade regulation of smooth muscle cell migration animal organ morphogenesis...

negative regulation of cytotoxic T cell degranulation regulation of ERK1 and ERK2 cascade regulation of homophilic cell adhesion negative regulation of vascular...

chemotaxis neutrophil chemotaxis immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma regulation of signaling receptor...

spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta". J...

regulation of epithelial cell proliferation negative regulation of ERK1 and ERK2 cascade negative regulation of p38MAPK cascade negative regulation of epithelium...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO Orthologs Databases NCBI: entry;...

1-phosphatidylinositol-3-kinase activity positive regulation of ERK1 and ERK2 cascade positive regulation of monocyte chemotaxis cellular response to amyloid-beta...

hypoxia-induced cell death acts through extracellular signal-regulated kinases ERK1, ERK2 and protein kinase Akt-1/PKB. The action of Epo is not limited to just promoting...

process positive regulation of phagocytosis positive regulation of ERK1 and ERK2 cascade positive regulation of amyloid-beta clearance positive regulation...

signaling pathway T cell differentiation negative regulation of ERK1 and ERK2 cascade erythrocyte differentiation negative regulation of lipid storage...

cell development ventricular septum morphogenesis regulation of ERK1 and ERK2 cascade ventricular compact myocardium morphogenesis heart trabecula morphogenesis...

binding positive regulation of ion transport positive regulation of ERK1 and ERK2 cascade sensory perception of pain response to growth factor positive regulation...

dual-specificity MAPK phosphatase Pyst2-L lead a monogamous relationship with the Erk2 protein?". Immunol. Lett. 92 (1–2): 149–56. doi:10.1016/j.imlet.2003.11.024...

tube development neuron differentiation notochord regulation of ERK1 and ERK2 cascade cell chemotaxis post-anal tail morphogenesis axial mesoderm formation...

blood vessel endothelial cell migration positive regulation of ERK1 and ERK2 cascade apoptotic signaling pathway positive regulation of dense core granule...

F; Wei, Yufeng (2012). "Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics". Biochimica et Biophysica Acta...

positive regulation of vascular wound healing positive regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-tyrosine phosphorylation positive...

remodeling negative regulation of gene expression positive regulation of ERK1 and ERK2 cascade positive regulation of p38MAPK cascade positive regulation of cardiac...

regulation of insulin receptor signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of adenylate cyclase-activating adrenergic receptor...

"Differential activation of extracellular signal-regulated kinase (ERK) 1, ERK2, p38, and c-Jun NH2-terminal kinase mitogen-activated protein kinases by...

of T cell migration neutrophil chemotaxis positive regulation of ERK1 and ERK2 cascade positive regulation of GTPase activity positive regulation of nitric-oxide...

response cellular response to interleukin-1 positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cell chemotaxis lymphocyte...

regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade protein autophosphorylation positive regulation of vascular endothelial...

blood vessel endothelial cell migration positive regulation of ERK1 and ERK2 cascade regulation of macrophage migration inhibitory factor signaling pathway...

peptide cellular response to hormone stimulus positive regulation of ERK1 and ERK2 cascade regulation of glucose transmembrane transport negative regulation...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO Orthologs Databases NCBI: entry;...

transcription by RNA polymerase II cell chemotaxis positive regulation of ERK1 and ERK2 cascade positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO...

positive regulation of DNA biosynthetic process positive regulation of ERK1 and ERK2 cascade positive regulation of endothelial cell chemotaxis by VEGF-activated...

positive regulation of apoptotic process negative regulation of ERK1 and ERK2 cascade negative regulation of angiogenesis regulation of growth cellular...

of cell migration sprouting angiogenesis positive regulation of ERK1 and ERK2 cascade negative regulation of vascular endothelial cell proliferation Sources:Amigo...

phosphatidylinositol 3-kinase activity cell chemotaxis positive regulation of ERK1 and ERK2 cascade platelet degranulation positive regulation of cell population proliferation...

negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO Orthologs Databases NCBI: entry;...