Draft:CHRNA8

  • Comment: Sources are fine, but I don't see why this single non-universal protein subunit deserves its own article, particularly one so short. Can't the content just be added to the Nicotinic acetylcholine receptor#Subunits article, maybe as a new subsection? WeirdNAnnoyed (talk) 20:39, 21 March 2026 (UTC)
  • Comment: No sources = no article. ChrysGalley (talk) 08:08, 8 March 2026 (UTC)


The α8 nicotinic acetylcholine receptor subunit (α8 nAChR; gene: CHRNA8) is a neuronal nicotinic acetylcholine receptor (nAChR) α-subunit identified in non-mammalian vertebrates. The α8 subunit can also form homomeric acetylcholine-gated ion channels and can heteromerize with other nAChR subunits to producereceptors with different pharmacological properties.[1][2]

α8 is an α-type nAChR subunit and contains the canonical features of neuronal α subunits.[1][3]

Clinical relevance

Since CHRNA8 is not present in mammalian genomes, it has no direct known clinical associations in humans.[4]

See also

References

  1. ^ a b Gerzanich, V; Anand, R; Lindstrom, J (February 1994). "Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties". Mol. Pharmacol. 45 (2): 212–220. PMID 7509438.
  2. ^ Pedersen, Julia E.; Bergqvist, Christina A.; Larhammar, Dan (January 30, 2019). "Evolution of vertebrate nicotinic acetylcholine receptors". BMC Evol. Biol. 19: 38. doi:10.1186/s12862-018-1341-8. PMC 6354393. PMID 30700248.
  3. ^ "CHRNA8 - Neuronal acetylcholine receptor subunit alpha-7 (Fragment) - Gallus gallus (Chicken)". UniProt. Retrieved 2026-03-08.
  4. ^ Pedersen, Julia E.; Bergqvist, Christina A.; Larhammar, Dan (2019). "Evolution of vertebrate nicotinic acetylcholine receptors". BMC Evolutionary Biology. 19: 38. doi:10.1186/s12862-018-1341-8. PMC 6354393. PMID 30700248.

Further reading

  • Gerzanich V, Anand R, Lindstrom J (1994). "Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties." Mol. Pharmacol. 45(2):212–220. PMID 7509438.
  • Pedersen JE, Bergqvist CA, Larhammar D (2019). "Evolution of vertebrate nicotinic acetylcholine receptors." BMC Evol. Biol. 19:38. doi:10.1186/s12862-018-1341-8. PMCID: PMC6354393.

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