Draft:CHRNA8
Submission declined on 21 March 2026 by WeirdNAnnoyed (talk).
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Submission declined on 8 March 2026 by ChrysGalley (talk). This draft is not adequately supported by reliable sources. Wikipedia's verifiability policy requires that all content be supported by reliable sources.
This draft's references do not show that the subject meets Wikipedia's criteria for inclusion. The draft requires multiple published secondary sources that:
Declined by ChrysGalley 2 months ago.
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Comment: The separate article is probably okay given that all other subunits in the table at Nicotinic acetylcholine receptor#Subunits have their own article and this is the last redlink. Laura240406 (talk) 17:31, 8 May 2026 (UTC)
Comment: Sources are fine, but I don't see why this single non-universal protein subunit deserves its own article, particularly one so short. Can't the content just be added to the Nicotinic acetylcholine receptor#Subunits article, maybe as a new subsection? WeirdNAnnoyed (talk) 20:39, 21 March 2026 (UTC)
Comment: No sources = no article. ChrysGalley (talk) 08:08, 8 March 2026 (UTC)
The α8 nicotinic acetylcholine receptor subunit (α8 nAChR; gene: CHRNA8) is a neuronal nicotinic acetylcholine receptor (nAChR) α-subunit identified in non-mammalian vertebrates. The α8 subunit can also form homomeric acetylcholine-gated ion channels and can heteromerize with other nAChR subunits to producereceptors with different pharmacological properties.[1][2]
α8 is an α-type nAChR subunit and contains the canonical features of neuronal α subunits.[1][3]
Clinical relevance
Since CHRNA8 is not present in mammalian genomes, it has no direct known clinical associations in humans.[4]
See also
References
- ^ a b Gerzanich, V; Anand, R; Lindstrom, J (February 1994). "Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties". Mol. Pharmacol. 45 (2): 212–220. PMID 7509438.
- ^ Pedersen, Julia E.; Bergqvist, Christina A.; Larhammar, Dan (January 30, 2019). "Evolution of vertebrate nicotinic acetylcholine receptors". BMC Evol. Biol. 19: 38. doi:10.1186/s12862-018-1341-8. PMC 6354393. PMID 30700248.
- ^ "CHRNA8 - Neuronal acetylcholine receptor subunit alpha-7 (Fragment) - Gallus gallus (Chicken)". UniProt. Retrieved 2026-03-08.
- ^ Pedersen, Julia E.; Bergqvist, Christina A.; Larhammar, Dan (2019). "Evolution of vertebrate nicotinic acetylcholine receptors". BMC Evolutionary Biology. 19: 38. doi:10.1186/s12862-018-1341-8. PMC 6354393. PMID 30700248.
Further reading
- Gerzanich V, Anand R, Lindstrom J (1994). "Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties." Mol. Pharmacol. 45(2):212–220. PMID 7509438.
- Pedersen JE, Bergqvist CA, Larhammar D (2019). "Evolution of vertebrate nicotinic acetylcholine receptors." BMC Evol. Biol. 19:38. doi:10.1186/s12862-018-1341-8. PMCID: PMC6354393.
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