DLGAP5

DLGAP5
Identifiers
AliasesDLGAP5, DLG7, HURP, discs large homolog associated protein 5, DLG associated protein 5
External IDsOMIM: 617859; MGI: 2183453; GeneCards: DLGAP5
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

9787

218977

Ensembl

ENSG00000126787

ENSMUSG00000037544

UniProt

Q15398

Q8K4R9

RefSeq (mRNA)

NM_001146015
NM_014750

NM_001145949
NM_144553

RefSeq (protein)

NP_001139487
NP_055565

NP_653136

Location (UCSC)Chr 14: 55.15 – 55.19 MbChr 14: 47.63 – 47.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.[5][6][7][8]

DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.[9] DGL7 is a part of Ran-dependent complex.[10] Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase.[11] Expression of DGL7 is found in cancer[12] and stem cells.[13]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126787 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037544 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  6. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  7. ^ "Entrez Gene: DLG7 discs, large homolog 7 (Drosophila)".
  8. ^ Bassal S, Nomura N, Venter D, Brand K, McKay MJ, van der Spek PJ (September 2001). "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1". Genomics. 77 (1–2): 5–7. doi:10.1006/geno.2001.6570. PMID 11543626.
  9. ^ Wilde A (June 2006). ""HURP on" we're off to the kinetochore!". J. Cell Biol. 173 (6): 829–31. doi:10.1083/jcb.200605150. PMC 2063907. PMID 16785318.
  10. ^ Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW (April 2006). "HURP is part of a Ran-dependent complex involved in spindle formation". Curr. Biol. 16 (8): 743–54. Bibcode:2006CBio...16..743K. doi:10.1016/j.cub.2006.03.056. PMID 16631581.
  11. ^ Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (July 2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. Cell. Biol. 25 (14): 5789–800. doi:10.1128/MCB.25.14.5789-5800.2005. PMC 1168800. PMID 15987997.
  12. ^ Sanderson HS, Clarke PR (June 2006). "Cell biology: Ran, mitosis and the cancer connection". Curr. Biol. 16 (12): R466–8. Bibcode:2006CBio...16.R466S. doi:10.1016/j.cub.2006.05.032. PMID 16782004.
  13. ^ Gudmundsson KO, Thorsteinsson L, Sigurjonsson OE, et al. (June 2007). "Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene". Stem Cells. 25 (6): 1498–506. doi:10.1634/stemcells.2005-0479. PMID 17322106. S2CID 25347875.

Further reading


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