CrcZ
| CrcZ | |
|---|---|
 Predicted secondary structure and sequence conservation of CrcZ | |
| Identifiers | |
| Symbol | CrcZ |
| Alt. Symbols | P29 |
| Rfam | RF01675 |
| Other data | |
| RNA type | sRNA |
| Domain | Bacteria |
| GO | GO:0045013 |
| SO | SO:0001263 |
| PDB structures | PDBe |
CrcZ is a small RNA found in Pseudomonas bacteria, which acts as a global regulator of carbon catabolite repression.[1] In P. aeruginosa, CrcZ is responsible for sequestering the protein Crc. Crc is an RNA-binding global regulator, which acts by inhibiting the translation of the transcriptional regulator AlkS.[2]
Function
In P. aeruginosa, CrcZ is a 407-nt long RNA which contains 5 CA-rich motifs. CrcZ expression is regulated by the two-component system CbrA/CbrB, in response to the availability of different carbon sources. As the Crc protein inhibits translation of transcriptional regulators by binding to and occluding the translational initiation site, sequestration of Crc by CrcZ binding means that Crc is unable to inhibit translation and transcriptional regulators, such as AlkS, are freely translated.[2] Expression of CrcZ is dependent on the carbon sources available to the bacteria; in the presence of preferred carbon sources (such as succinate), CrcZ expression is low, and catabolite repression is high. In the presence of poor sources of carbon, such as mannitol, CrcZ expression is high, allowing the inhibition of Crc and a subsequent decrease in catabolite repression occurs.[1]
References
- ^ a b Sonnleitner E, Abdou L, Haas D (December 2009). "Small RNA as global regulator of carbon catabolite repression in Pseudomonas aeruginosa". Proceedings of the National Academy of Sciences of the United States of America. 106 (51): 21866–21871. doi:10.1073/pnas.pnas.0910308106. PMC 2799872. PMID 20080802.
- ^ a b Moreno R, Ruiz-Manzano A, Yuste L, Rojo F (May 2007). "The Pseudomonas putida Crc global regulator is an RNA binding protein that inhibits translation of the AlkS transcriptional regulator". Molecular Microbiology. 64 (3): 665–675. doi:10.1111/j.1365-2958.2007.05685.x. PMID 17462015. S2CID 37274996.
Further reading
- Filiatrault MJ, Stodghill PV, Wilson J, Butcher BG, Chen H, Myers CR, Cartinhour SW (February 2013). "CrcZ and CrcX regulate carbon source utilization in Pseudomonas syringae pathovar tomato strain DC3000". RNA Biology. 10 (2): 245–255. doi:10.4161/rna.23019. PMC 3594283. PMID 23353577.
- Sonnleitner E, Bläsi U (June 2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics. 10 (6) e1004440. doi:10.1371/journal.pgen.1004440. PMC 4063720. PMID 24945892.
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