CLDN18
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[5] It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[6] [supplied by OMIM][5]
Clinical significance
Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[7]
Zolbetuximab targets Claudin 18.2 to help treat gastric and gastroesophageal junction cancers.[8][9] [10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000066405 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032473 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CLDN18 claudin 18".
- ^ Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911. PMID 11585919.
- ^ Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016
- ^ "Astellas' VYLOY™ (zolbetuximab) Approved in Japan for Treatment of Gastric Cancer a". www.prnewswire.com. 2024-03-26. Retrieved 2024-09-29.
- ^ Ouladan S, Orouji E (March 2025). "CAR-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy". Journal of Clinical Oncology. 42 (23): 2637–2639. doi:10.1200/JCO.24.02081. PMC 11895826. PMID 39805063.
- ^ Liu, Jian; Yang, Jing; Sun, Ying (July 2025). "CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial". Nature Medicine. na (na): s41591-025-03783-8. doi:10.1038/s41591-025-03783-8. PMC 12443601. PMID 40670773.
External links
- Human CLDN18 genome location and CLDN18 gene details page in the UCSC Genome Browser.
Further reading
- Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC 11537529. PMID 10690502. S2CID 26473781.
- Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
- Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
- Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
- González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
- Matsuda Y, Semba S, Ueda J, et al. (2007). "Gastric and intestinal claudin expression at the invasive front of gastric carcinoma". Cancer Sci. 98 (7): 1014–9. doi:10.1111/j.1349-7006.2007.00490.x. PMC 11159341. PMID 17459057. S2CID 28029778.
- Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.
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