CLASP1
Cytoplasmic linker associated protein 1, also known as CLASP1, is a protein which in humans is encoded by the CLASP1 gene.[5]
Function
CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals[6] and plants.[7] CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle.[5][8] CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle.[9]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000074054 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064302 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CLASP1 cytoplasmic linker associated protein 1".
- ^ Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, et al. (July 2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Developmental Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
- ^ Ambrose JC, Wasteneys GO (2008). "CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules". Molecular Biology of the Cell. 19 (11): 4730–4737. doi:10.1091/mbc.E08-06-0665. PMC 2575154. PMID 18716054.
- ^ Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC (June 2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. hdl:10216/53832. PMID 12837247.
- ^ Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD (August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID 21822276. S2CID 8869880.
External links
- Human CLASP1 genome location and CLASP1 gene details page in the UCSC Genome Browser.
- Human MAST1 genome location and MAST1 gene details page in the UCSC Genome Browser.
Further reading
- Galjart N (June 2005). "CLIPs and CLASPs and cellular dynamics". Nature Reviews. Molecular Cell Biology. 6 (6): 487–498. doi:10.1038/nrm1664. PMID 15928712. S2CID 23216754.
- Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.
- Lemos CL, Sampaio P, Maiato H, Costa M, Omel'yanchuk LV, Liberal V, et al. (July 2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization". The EMBO Journal. 19 (14): 3668–3682. doi:10.1093/emboj/19.14.3668. PMC 313969. PMID 10899121.
- Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, et al. (March 2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–935. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
- Maiato H, Rieder CL, Earnshaw WC, Sunkel CE (2004). "How do kinetochores CLASP dynamic microtubules?". Cell Cycle. 2 (6). Georgetown, Tex.: 511–514. doi:10.4161/cc.2.6.576. hdl:10216/35062. PMID 14504462.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, Sasaki H, Matsui C, Severin F, et al. (January 2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". The Journal of Cell Biology. 168 (1): 141–153. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
- Venables JP, Bourgeois CF, Dalgliesh C, Kister L, Stevenin J, Elliott DJ (August 2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Human Molecular Genetics. 14 (16): 2289–2303. doi:10.1093/hmg/ddi233. PMID 16000324.
- Aonuma M, Miyamoto M, Inoue YH, Tamai K, Sakai H, Kamasawa N, et al. (2005). "Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment". Cell Structure and Function. 30 (1): 7–13. doi:10.1247/csf.30.7. PMID 16145243.
- Mimori-Kiyosue Y, Grigoriev I, Sasaki H, Matsui C, Akhmanova A, Tsukita S, et al. (August 2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment". Genes to Cells. 11 (8): 845–857. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869. S2CID 33744175.
- Pereira AL, Pereira AJ, Maia AR, Drabek K, Sayas CL, Hergert PJ, et al. (October 2006). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function". Molecular Biology of the Cell. 17 (10): 4526–4542. doi:10.1091/mbc.E06-07-0579. PMC 1635371. PMID 16914514.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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