DOSEN PROFIL LENGKAP

CHST1
Identifiers
Aliases	CHST1, C6ST, GST-1, KS6ST, KSGal6ST, KSST, carbohydrate sulfotransferase 1
External IDs	OMIM: 603797; MGI: 1924219; GeneCards: CHST1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	45,665,622 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	92,445,595 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; middle frontal gyrus; ; parietal lobe; ; amygdala; ; anterior cingulate cortex; ; right frontal lobe; ; postcentral gyrus; ; orbitofrontal cortex; ; dorsolateral prefrontal cortex;
	Top expressed in
	lacrimal gland; ; molar; ; habenula; ; olfactory tubercle; ; subiculum; ; temporal lobe; ; prefrontal cortex; ; nucleus accumbens; ; primary motor cortex; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; N-acetylglucosamine 6-O-sulfotransferase activity; keratan sulfotransferase activity;
Cellular component	Golgi membrane; Golgi apparatus; membrane; integral component of membrane; trans-Golgi network;
Biological process	sulfur compound metabolic process; galactose metabolic process; inflammatory response; keratan sulfate biosynthetic process; polysaccharide metabolic process; keratan sulfate metabolic process; carbohydrate metabolic process; N-acetylglucosamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8534
	76969
	ENSG00000175264
	ENSMUSG00000027221
	O43916
	Q9EQC0
	NM_003654
	NM_023850; NM_001356552; NM_001356553
	NP_003645
	NP_076339; NP_001343481; NP_001343482
	Wikidata
View/Edit Human	View/Edit Mouse

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175264 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027221 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fukuta M, Inazawa J, Torii T, Tsuzuki K, Shimada E, Habuchi O (Jan 1998). "Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase". J Biol Chem. 272 (51): 32321–8. doi:10.1074/jbc.272.51.32321. PMID 9405439.
^ Mazany KD, Peng T, Watson CE, Tabas I, Williams KJ (Aug 1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization". Biochim Biophys Acta. 1407 (1): 92–7. doi:10.1016/s0925-4439(98)00028-3. PMID 9639683.
^ "Entrez Gene: CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1".

External links

Human CHST1 genome location and CHST1 gene details page in the UCSC Genome Browser.

Williams KJ (1997). "Atherosclerosis: cell biology and lipoproteins". Curr. Opin. Lipidol. 7 (6): U202–8. doi:10.1097/00041433-199612000-00016. PMID 9117134.
Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
Li X, Tedder TF (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. 55 (3): 345–7. doi:10.1006/geno.1998.5653. PMID 10049591.
Bistrup A, Bhakta S, Lee JK, et al. (1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin". J. Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194. PMID 10330415.
Tu L, Murphy PG, Li X, Tedder TF (1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1". J. Immunol. 163 (9): 5070–8. doi:10.4049/jimmunol.163.9.5070. PMID 10528213.
Torii T, Fukuta M, Habuchi O (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase". Glycobiology. 10 (2): 203–11. doi:10.1093/glycob/10.2.203. PMID 10642612.
Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4): 565–74. doi:10.1189/jlb.69.4.565. PMID 11310842. S2CID 8888883.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yamada T, Ohtake S, Sato M, Habuchi O (2005). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". Biochem. J. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMC 1134142. PMID 15324304.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Liu J, Chau CH, Liu H, et al. (2006). "Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth". J. Cell Sci. 119 (Pt 5): 933–42. doi:10.1242/jcs.02796. hdl:10722/44575. PMID 16495484.
Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". J. Biol. Chem. 282 (41): 30085–96. doi:10.1074/jbc.M703695200. PMID 17690104.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175264 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027221 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9405439-5] Fukuta M, Inazawa J, Torii T, Tsuzuki K, Shimada E, Habuchi O (Jan 1998). "Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase". J Biol Chem. 272 (51): 32321–8. doi:10.1074/jbc.272.51.32321. PMID 9405439.

[pmid9639683-6] Mazany KD, Peng T, Watson CE, Tabas I, Williams KJ (Aug 1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization". Biochim Biophys Acta. 1407 (1): 92–7. doi:10.1016/s0925-4439(98)00028-3. PMID 9639683.

[entrez-7] "Entrez Gene: CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1".

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DOSEN PROFIL LENGKAP

CHST1

References

External links

Further reading

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